Doxorubicin (DOX) is an important anthracycline antibiotic whose intricate features of binding to DNAs, not yet fully understood, have been the object intense debate. The dimerization equilibrium has studied at pH = 7.0, I 2.5 mM, and T 25 °C. A thermodynamic kinetic study doxorubicin DNA, carried out by circular dichroism, viscometry, differential scanning calorimetry, fluorescence, isothermal titration T-jump relaxation measurements, enabled us characterize for first time two different...

The thermophysical properties of the (C1−C11) alkan-1-ol/(C1−C4) alkylbenzoate mixed solvents at atmospheric pressure and 298.15 K were studied over whole composition range. intermolecular interactions structural effects analyzed on basis measured derived properties. From experimental data, parameters extended real associated solution Prigogine−Flory−Patterson models used to correlate interpret excess molar volumes. ability Soave−Redlich−Kwong Peng−Robinson equations state combined with a...

Excess volumes, mixing viscosities, and excess Gibbs energies of activation viscous flow the aqueous binary mixtures amides formamide, N-methylformamide, N,N-dimethylformamide, pyrrolidin-2-one, N-methyl-2-pyrrolidinone were calculated from density viscosity measurements. The values these functions point to strong amide−water interactions with formation a variety aggregates, nature which depends on extent substitution amides; comparison same alkan-1-ols reveal an important hydration effect....

This work reports on a theoretical and experimental study the ionic liquid 1-butyl-3-methylimidazolium octylsulfate ([BMIM]OS). The halogen-free [BMIM]OS is stable solvent regarding hydrolysis, whose availability, toxicologically favourable features well documented biodegradability turns it into suitable candidate for different multiton-scale industrial applications. pressure–volume–temperature behaviour of this fluid has been evaluated accurately over wide ranges temperature pressure,...

Abstract Six independent experiments of common design were performed in laboratories Canada, Spain, Sweden, and the United States America. Fertilized eggs domestic chickens incubated as controls or a pulsed magnetic field (PMF); embryos then examined for developmental anomalies. Identical equipment each laboratory consisted two incubators, containing Helmholtz coil electronic devices to develop, control, monitor temperature, relative humidity, vibrations. A unipolar, pulsed, (500‐μs pulse...

The ligands 2-pyridin-2-yl-1H-benzimidazole (HL1), 1-methyl-2-pyridin-2-ylbenzimidazole (HL2), and 2-(1H-imidazol-2-yl)pyridine (HL3) the proligand 2-phenyl-1H-benzimidazole (HL4) have been used to prepare five different types of new ruthenium(II) arene compounds: (i) monocationic complexes with general formula [(η6-arene)RuCl(κ2-N,N-HL)]Y [HL = HL1, HL2, or HL3; Y Cl BF4; 2-phenoxyethanol (phoxet), benzene (bz), p-cymene (p-cym)]; (ii) dicationic aqua [(η6-arene)Ru(OH2)(κ2-N,N-HL1)](Y)2 (Y...

Abstract Subnanometric samples, containing exclusively Ag 2 and 3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without use of surfactants or capping agents. By combination thermodynamic measurements theoretical calculations, we show herein that clusters interact with DNA through intercalation, inducing significant structural distortion to DNA. The lifetime in intercalated position is two three orders magnitude longer than classical...

This work presents a theoretical study of acetohydroxamic acid and its protonation processes using ab initio methodology at the MP2(FC)/cc-pdVZ level. We find amide form more stable than imidic tautomer by less 1.0 kcal mol(-)(1). For comparison with experimental data, three-dimensional conformational is performed on most (amide). From this study, different barriers to rotation inversion are determined intramolecular hydrogen bond between OH group carbonyl oxygen characterized. The...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShear viscosities of binary liquid mixtures: 2-pyrrolidinone with 1-alkanolsBegona Garcia, Cesar Herrera, and Jose M. LealCite this: J. Chem. Eng. Data 1991, 36, 3, 269–274Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/je00003a004https://doi.org/10.1021/je00003a004research-articleACS PublicationsRequest reuse permissionsArticle...

Excess volumes, excess viscosities, and exess Gibbs energies of activation for viscous flow binary liquid mixtures formamide with (C1–C5) alkan-1-ols have been calculated from the densities viscosities measured at 298.15 K over whole composition range. The viscosity–mole fraction data five systems were used to test various empirical laws proposed describe viscosity mixtures: one-parameter models by Nissan–Grunberg, Hind–McLaughlin–Ubbelohde Teja–Rice, two-parameter McAllister, Heric, Lobe,...

The synthesis and full characterization of the new aqua-complex [(η6-p-cymene)Ru(OH2)(κ2-N,N-2-pydaT)](BF4)2, [2](BF4)2, nucleobase derivative [(η6-p-cymene)Ru(9-MeG)(κ2-N,N-2-pydaT)](BF4)2, [4](PF6)2, where 2-pydaT = 2,4-diamino-6-(2-pyridyl)-1,3,5-triazine 9-MeG 9-methylguanine, are reported here. crystal structures both [4](PF6)2 chloro complex [(η6-p-cymene)RuCl(κ2-N,N-2-pydaT)](PF6), [1](PF6), have been elucidated by X-ray diffraction. former provided relevant information regarding...

Viscosities of some N-methylformamide– and N,N-dimethylformamide–(C 1 –C 10 ) alkan-1-ol binary mixtures have been measured at 298.15 K over the whole composition range. The excess viscosities Gibbs energies activation for viscous flow, compared with values other amide–alcohol mixed solvents, suggest that alcohol size does not play a significant role in mixture behaviour. aliphatic amides gave heteroaggregates to greater extent, lower self-association pure amides. An analysis terms solvent...

The considerable interest aroused in recent years by the unique properties and industrial applications of ionic liquids has given rise to need for a detailed statement linkage between their molecular features observed macroscopic behavior. A combined experimental/computational approach study is submitted here applied relevant, nonhalogenated 1,3-dimethylimidazolium methylsulfate 1-ethyl-3-methylimidazolium tosylate. To establish reliable equation state pertinent these fluids, density data...

Densities, viscosities and refractive indices of the N-methylpyrrolidone + alkan-1-ols (C1–C10) binary systems at 298.15 K atmospheric pressure have been measured over whole composition range; from these measurements values for excess molar volumes, mixing viscosities, internal pressures, Gibbs energies activation viscous flow were calculated. The molecular interactions in mixtures can be interpreted on basis variation functions with mixture composition. cubic equations state proposed by...

As part of a study on the interactions between aromatic esters and n-alkanes, density, viscosity, refractive index data were measured for methylbenzoate−n-alkane mixed solvents. From these data, excess molar volumes ( ), mixing viscosities (Δmixη), Gibbs energies activation viscous flow (Δ indices (ΔmixnD) deduced. volumes, partial two components deduced using intercept method. The cubic equations state (EOS) proposed by Soave−Redlich−Kwong Peng−Robinson combined with simple rules used to...

The interactions of triple strands poly(rA)·2poly(rU) with proflavine (PR) and the cis-platinum derivative [{PtCl (tmen)}2{NC13H7(NCH2CH2)2}]+ (PRPt) are examined at pH 7.0, T = 25 °C, 0.2 M ionic strength by spectrophotometry, spectrofluorometry, circular dichroism, viscosimetry, stopped-flow, T-jump relaxation techniques. melting experiments demonstrate that both drugs tend to destabilize triplex structure, although PRPt effect is more relevant. By contrast, slightly stabilize duplex...

Abstract The reactions of two diaminotriazine ligands 2,4‐diamino‐6‐(2‐pyridyl)‐1,3,5‐triazine (2‐pydaT) and 6‐phenyl‐2,4‐diamino‐1,3,5‐triazine (PhdaT) with ruthenium–arene precursors led to a new family ruthenium(II) compounds that were spectroscopically characterized. Four the complexes cationic, general formula [( η 6 ‐arene)Ru( κ 2 ‐ N , ‐2‐pydaT)Cl]X (X=BF 4 TsO; arene= p ‐cymene: 1.BF4 1.TsO arene=benzene: 2.BF4 2.TsO ). neutral cyclometalated complex ‐cymene)Ru( C ‐PhdaT*)Cl] ( 3 )...

New cationic, half-sandwich Ru(II) arene compounds of general formula [(η(6)-arene)RuCl(κ(2)-N,N-L)]X (where L are functionalized phenanthrolines such as 1,10-phenanthroline-5-amine (aphen); 5,6-epoxy-5,6-dihydro-[1,10]phenanthroline (ephen); or 4,7-dihydroxy-1,10-phenanthroline (dhphen)) have been prepared to study their anticancer potential. All the isolated complexes fully characterized by spectroscopic and analytical techniques. The structure...

This work contributes to an improved understanding of the structure and dynamics ester-containing solvents. A broad experimental study has been performed on thermophysical properties (C6−C14) n-alkane + (C1−C4) alkylbenzoate binary solvents over whole composition range within 278.15−318.15 K temperature range. The excess mixing derived were analyzed in terms structural effects intermolecular forces. To put forward reliable models that may describe behavior these complex mixtures, cubic...

Preferential solvation and intermolecular interactions of the solvatochromic indicators 4-nitroanisole, 4-nitroaniline, 4-nitrophenol, Reichardt's dye is studied at 298.15 K in binary solvents 2-pyrrolidinone/water, N-methylpyrrolidinone/water, 2-pyrrolidinone/N-methylpyrrolidinone. From experimental data Kamlet−Taft parameters were evaluated for mixed solvents. A preferential model was applied to analyze effect indicator by different used, from these useful information about solute−solvent...

A wide study was carried out of the acid–base behaviour ferricyanide ions in aqueous perchloric acid media range 0.1–11.5 M. This shows that protonation and decomposition occur simultaneously. The three successive equilibria were found acidity ranges 0.1–4.0, 3.5–8.5, 7.0–11.5 M HClO 4 , respectively. kinetic also made reaction at 60 °C. data are explained by considering a mechanism involving homolytic heterolytic dissociation steps. rate constants corresponding to each four protonated...