A5063270552- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Lipid Membrane Structure and Behavior
- Polysaccharides Composition and Applications
- Natural Antidiabetic Agents Studies
- Analytical Chemistry and Chromatography
- Ocular Surface and Contact Lens
- Antibiotics Pharmacokinetics and Efficacy
- Bee Products Chemical Analysis
- Moringa oleifera research and applications
- African Botany and Ecology Studies
- Hibiscus Plant Research Studies
- Malaria Research and Control
- Antimicrobial Resistance in Staphylococcus
- Ethnobotanical and Medicinal Plants Studies
- Analytical Methods in Pharmaceuticals
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Morinda citrifolia extract uses
- RNA Interference and Gene Delivery
- Antifungal resistance and susceptibility
- Pharmaceutical studies and practices
- HIV/AIDS Research and Interventions
Helmholtz Centre for Infection Research
2023-2024
University of Nigeria
2015-2024
Helmholtz Institute for Pharmaceutical Research Saarland
2014-2024
Saarland University
2014-2023
CIBBIM-Nanomedicine
2021-2023
University of Birmingham
2022
University of Benin
2014
Shivaji University
2012
AREA Science Park
2010
Availability and accessibility of sexual reproductive health services for adolescents are very crucial prevention control problems. These also play vital roles in the promotion adolescents' generally. The main purpose study was to determine availability (geographical financial) (SRHS) among Enugu State, Nigeria.A mixed methods approach adopted study. 192 facilities were reached check SRH services. Randomly sampled 1447 (12-22 years) completed questionnaire correctly. Twenty-seven interviews...
Many formulation strategies have been employed to improve ocular bioavailability of topical eye drops. The aim this study was develop and evaluate a series solid lipid nanoparticles coated with poly(2-ethyl-2-oxazoline) chitosan for delivery ciprofloxacin. Ciprofloxacin-loaded (PSLN) prepared by combination melt-emulsion sonication low-temperature solidification methods. A Box-Behnken design, statistically optimize the effects amount drug (X1), lipid:polymer ratio (X2) surfactant...
Abstract Artemisinins, the mainstay in treatment of malaria today, are used combination with other antimalarials to forestall resistance, as artemisinin-combination therapies. In line World Health Organization’s recommendation that respect, solid lipid nanoparticles (SLN) were formulated encapsulate two antimalarial drugs — artemether and lumefantrine. The evaluated for size state properties. Caco-2 cells investigate ability SLN deliver its payload at absorptive interface gastrointestinal...
The aim of this study was to investigate the potential microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] polyethylene glycol- (PEG-) 4000 improve intravaginal delivery miconazole nitrate (MN) for effective treatment vulvovaginal candidiasis (VVC). Lipid matrices (LMs) consisting rational blends SF SO with or without PEG-4000 were prepared by fusion characterized employed formulate MN-loaded solid lipid (SLMs)...
The leaf of Moringa oleifera (Lam) Moringaceae, is globally accepted in ethnomedicine and particularly used to tackle malnutrition enhance breast milk production resource-limited settings. It reported be laden with a wide array interesting bioactive plant metabolites. However, its safety at conception during pregnancy has not been well notably Nigeria. This work investigated the vitro vivo uteroactive contraceptive potentials cold hot aqueous extracts M. leaves (MOL) commonly Nigerian...
The purpose of this study was to formulate and evaluate novel PEGylated solidified reverse micellar solutions (SRMS)-based solid lipid microparticles (SLMs) for improved delivery gentamicin. Lipid matrix (SRMS) [consisting 15% w/w Phospholipon® 90G (P90G) in 35% dika wax (Irvingia gabonensis) formulated characterized by differential scanning calorimetry (DSC). SLMs were melt-emulsification using the SRMS, PEG 4000 gentamicin (1.0, 2.0, 3.0% w/w), their physicochemical as well pharmacokinetic...
To investigate three tropical plant materials – clove seeds [Syzygium aromaticum (S. aromaticum)], bitter kola fruits [Garcinia (G. kola)] and tobacco leaves (Nicotiana species) as potential targeted killers of Streptococcus mutans mutans), a cavity-causing bacterium (gram-positive, facultative anaerobe) that resides in multispecies microbial community (dental plaque) for the treatment dental caries (tooth decay). Thirty one (31) teeth samples were collected from patients with obvious signs...
The lipid-rich Seed of Moringa oleifera has been promoted as an effective water clarifier. Aside its vital nutritional application emerging food additive, the seed continued to gain a wider acceptance in various global ethnomedicines for managing several communicable and lifestyle diseases, howbeit, potential toxic effect, particularly on fertility pregnancy outcomes remained uninvestigated; effect (MOSE) aqueous-methanol extracts outcome, was investigated vivo using female Wistar rats that...
Purpose: To formulate hydrogels based on poloxamer 407 and polyacrylic acids (Carbopols® 971P 974P), evaluate its suitability for enhanced topical delivery of gentamicin, a potent but highly toxic aminoglycoside antibiotic.Methods: Topical gentamicin were produced using polyacrlic evaluated in terms drug content, pH, physical assessment, viscosity stability. In vitro antimicrobial release was conducted four microorganisms –Escherichia coli, Salmonella typhi, Staphylococcus aureus Pseudomonas...
Abstract: The present study aimed to develop low-dose liquisolid tablets of two antimalarial drugs artemether–lumefantrine (AL) from a nanostructured lipid carrier (NLC) lumefantrine (LUM) and estimate the potential AL as an oral delivery system in malariogenic Wistar mice. LUM-NLCs were prepared by hot homogenization using Precirol ® ATO 5/Transcutol HP tallow fat/Transcutol optimized systems containing 3:1 ratios lipids, respectively, matrices. LUM-NLC characteristics, including...
Effective oral insulin delivery has remained a challenge to the pharmaceutical industry. This study was designed evaluate effect of magnesium stearate on properties insulin-loaded Eudragit® RL 100 entrapped mucoadhesive microspheres. Microspheres containing 100, insulin, and varying concentrations (agglomeration-preventing agent) were prepared by emulsification-coacervation method characterized with respect differential scanning calorimetry (DSC), morphology, particle size, loading...
Quinine hydrochloride (QHCl) has remained a very relevant antimalarial drug 400 years after its effectiveness was discovered. Unlike other antimalarials, the development of resistance to quinine been slow. Hence, this is date still used for treatment severe and cerebral malaria, malaria in all trimesters pregnancy, combination with doxycycline against multidrug-resistant parasites. The decline administration over mainly associated poor tolerability due gastrointestinal (GIT) side effects...
Herein, we report the properties of nanostructured lipid carriers (NLCs) prepared with a gradient concentration Bergenin (BGN) isolated from Pentaclethra macrophylla stem bark powder. A BGN (BGN 0, 50, 100, 150, and 200 mg) was in 5 % matrix consisting Transcutol HP (75 %), Phospholipon 90H (15 Gelucire 43/01 (10 %) to which surfactant aqueous phase Tween 80, sorbitol, sorbic acid dissolved. The NLCs were evaluated by size, polydispersity index (PDI), zeta potential, Fourier Transform...
Objective To preliminarily investigate three different lipid matrices consisting of two natural homolipids from Capra hircus (goat fat) and Bovine Spp. (tallow one semi-synthetic (Softisan® 142) separately structured with Phospholipon® 90G (P90G) as potential delivery systems for poorly water soluble drugs.
People living with diabetes mellitus across the world are expected to rise 592 million by 2035 and pandemic disease is worst in developing countries like Nigeria, where cost of treating/managing relatively out reach many diabetic patients. The study investigated effect Anogeissus leiocarpus Guill Perr ethanolic leaf extract on blood glucose other biochemical indices alloxan-induced adult male Wistar albino rats. Diabetes was induced overnight-fasted rats a single intraperitoneal injection...