A5066808378- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Vitamin D Research Studies
Human Technopole
2023
University of Milan
2022
Astrocytes are involved in Parkinson's disease (PD) where they could contribute to α-Synuclein pathology but also neuroprotection via clearance. The molecular signature underlying their dual role is still elusive. Given that vitamin D has been recently suggested be protective neurodegeneration, the aim of our study was investigate astrocyte and neuron pathway alterations correlation with aggregates (ie, oligomers fibrils) human brain obtained from PD patients.The expression components...
Abstract Mpox, formerly known as monkeypox, is a zoonotic illness of international concern that can lead to severe disease including neurological sequelae. However, it remains unclear what the neurotropism monkeypox virus (MPXV) and how MPXV infection leads deficits. Here, we determined neurovirulence using human pluripotent stem cell- (hPSC)-derived neural cells, astrocytes, cortical neurons, microglia together with ex vivo brain tissue. We found infects replicates more efficiently in...