A5057421655- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Craniofacial Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- Cleft Lip and Palate Research
- Medical Malpractice and Liability Issues
- Healthcare Quality and Management
- Congenital Diaphragmatic Hernia Studies
- Neurological disorders and treatments
- Spinal Cord Injury Research
- Cancer Genomics and Diagnostics
- Spinal Fractures and Fixation Techniques
- Long-Term Effects of COVID-19
- Blood disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Immunodeficiency and Autoimmune Disorders
- Cancer-related cognitive impairment studies
- Neurosurgical Procedures and Complications
- Cervical and Thoracic Myelopathy
- Connective tissue disorders research
- Advanced Chemical Sensor Technologies
Erasmus MC
2016-2025
Erasmus University Rotterdam
2013-2025
Erasmus MC - Sophia Children’s Hospital
2023-2024
The Netherlands Cancer Institute
2024
Children's Medical Center
2017-2023
Erasmus MC Cancer Institute
2014-2021
Great Ormond Street Hospital
2021
University College London
2021
Creative Commons
2019
Tehran University of Medical Sciences
2017-2018
COVID-19 patients commonly present with signs of central nervous system and/or peripheral dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection DA triggers an inflammatory cellular senescence response. High-throughput screening in hPSC-derived identified several FDA-approved drugs can rescue the...
The primary aim was to assess the feasibility of robotic OSB repair in a simulation training model, documenting learning curve and ensuring quality control among surgeons. assessed using cumulative summation test (LC-CUSUM). Following LC-CUSUM, six additional experiments were performed for competency-cumulative (C-CUSUM) analysis ensure ongoing control. simulator created through 3D printing hand sculpting, simulating partially exteriorised uterus laparotomy-assisted laparoscopic surgery. It...
<title>Abstract</title> COVID-19 patients commonly present with neurological signs of central nervous system (CNS) and/or peripheral dysfunction. However, which neural cells are permissive to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been controversial. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem (hPSCs) selectively SARS-CoV-2 both in vitro and upon transplantation vivo, triggers a DA neuron inflammatory cellular...
Glioblastoma has shown resistance to histone deacetylase inhibitors (HDACi) as radiosensitizers in cultures withBcl-XL over-expression.We study the efficacy of SAHA/RTx and LBH589/RTx when manipulating Bcl-2 family proteins using inhibitor Obatoclax patient-derived glioblastoma stem-like cell (GSC) cultures.GSC general have a deletion phosphatase tensin homolog (PTEN).Synergy was determined by Chou Talalay method.The effects on apoptosis autophagy were studied measuring caspase-3/7, Bcl-XL,...
OBJECTIVE Myelomeningocele (MMC) is the most common form of spina bifida, with a lifelong impact on quality life for infants born this condition. In recent decades, fetal surgery has evolved from an experimental therapy to standard care many centers in world. study, authors aimed provide overview current management and outcomes MMC managed at their institution. This then provides center-specific historical cohort comparison future antenatal-treated cases. METHODS retrospective,...
Background Only a small group of patients with glioblastoma multiforme (GBM) survives more than 36 months, so-called long-term survivors. Recent studies have shown that chromosomal instability (CIN) plays prognostic and predictive role among different cancer types. Here, we compared histological (chromosome missegregation) bioinformatic metrics (CIN signatures) CIN in tumors GBM typical survivors (≤36 months overall survival), isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas....
In previous studies, surgical specialties accounted for most malpractice claims. The objective of the present study was to determine risk claims physicians working in hospitals. A retrospective observational using anonymized closed between 2007 up 2021 from two Dutch insurers carried out. Main outcomes involved claim volume & outcome, and estimated annual (EAR) a per year individual physician all specialties. Sustained or settled were considered unfavorable (UOP). Surgical specialists,...
ABSTRACT Background Increased intracranial pressure (ICP) can be observed immediately upon seizure activity in craniotomized patients neurosurgical practice. However, it is not commonly included models of pathomechanisms contributing to morbidity and mortality epilepsy. A main contributor this may the fact that measuring ICP noninvasively during a technically challenging. The optic nerve sheath diameter (ONSD) represents promising, noninvasive option monitor relative changes. We therefore...
OBJECTIVE The aim of this study was to investigate the global variability in intraoperative neurosurgical management strategies for fetal spina bifida surgery. METHODS All prenatal surgery centers identified through International Society Prenatal Diagnosis website and previous literature were invited participate an online survey addressing various aspects surgery, including selection criteria, surgical technique, common challenges. RESULTS Thirty-four (72%) responded survey, more than half...
Introduction Traditionally, surgical intervention has been the standard treatment for children with metopic synostosis, assuming that it reduces risk of raised intracranial pressure, thereby preventing vision and cognitive impairment, also restores abnormal head shape. However, recent research suggests a sporadic occurrence pressure in patients synostosis. In addition, following surgery, an overall tendency to have worse behavioral outcomes more refractive errors compared healthy peers is...
12035 Background: The safety of silicone breast implants (SBIs) has been challenged in various large observational studies that suggest an association with autoimmune and rheumatic diseases (ARDs). Additionally, increasing number women seem to attribute constitutional, rheumatic, mental cognitive symptoms their SBIs. This constellation is often referred as ‘Breast implant illness (BII). To date, BII a self-identified diagnosis without evidence-based definition. risks ARDs have not evaluated...
Since the completion of Management Myelomeningocoele Study, maternal-fetal surgery for spina bifida has become a valid option expecting parents. More recently, multiple groups are exploring minimally invasive approach and recent outcomes have addressed many initial concerns with this approach. Based on previously published framework, we attempt to delineate developmental stage surgical techniques. Furthermore, discuss barriers performing randomized controlled trials comparing two...
Abstract Introduction Literature on outcomes of patients with Lennox–Gastaut syndrome (LGS) receiving adjunctive vagus nerve stimulation (VNS) lacks information seizure types and the time course therapeutic effects. We have therefore performed what is to our knowledge largest most in‐depth analysis effectiveness VNS in LGS paying special attention impact Therapy individual types. Methods The Outcomes Registry includes over 7000 patients. A propensity score matching method was employed match...
Cervical vagus nerve stimulation is in a great variety of clinical situations indicated as form treatment. It textbook knowledge that at the cervical level contains many different fiber classes. Yet, recently, several reports have shown this also may contain an additional class potentially noradrenergic fibers, suggested to denote efferent sympathetic fibers. As such, nature and presence these fibers should be considered when choosing protocol. We studied human material extracted from...
Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is a rare rapidly progressive neurodegenerative disorder, resulting in early death. Intracerebroventricular enzyme replacement therapy (ERT) with cerliponase alfa now available and has shown to delay disease progression symptomatic patients. It yet unknown if can prevent onset presymptomatic patients.We evaluated the effect of years intracerebroventricular ERT two siblings CLN2 disease, one (age 47 months) 23 at treatment start, using...
Abstract: Circulating tumor DNA (ctDNA) analysis is a promising non-invasive technique for active surveillance after chemoradiotherapy locally advanced resectable esophageal carcinoma. In other malignancies false-positive results in ctDNA have been reported due to clonal hematopoiesis. this case, we present 66-year-old male who had adenocarcinoma of the gastroesophageal junction which he received neoadjuvant and underwent transhiatal esophagectomy. Postoperatively our patient follow-up with...
Abstract Objective The aim of this work is to define competencies and entrustable professional activities (EPAs) be imparted within the framework surgical neuro-oncological residency fellowship training as well education medical students. Improved specific in neuro-oncology promotes expertise, quality treatment may also contribute further development techniques protocols. Specific curricula for a neuro-oncologic have not yet been established. Methods We used consensus-building approach...