A5020793263- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Sports Performance and Training
- Cardiovascular and exercise physiology
- Biochemical effects in animals
- Schizophrenia research and treatment
- Amino Acid Enzymes and Metabolism
- Muscle metabolism and nutrition
- Biochemical Acid Research Studies
- Coenzyme Q10 studies and effects
- Diabetes and associated disorders
- Neuroscience and Neuropharmacology Research
- Physical Education and Gymnastics
- Sports Analytics and Performance
- Neonatal and fetal brain pathology
- Mental Health Research Topics
- Nutrition and Health in Aging
- Mental Health and Psychiatry
- Psychoanalysis and Psychopathology Research
- Genetics and Physical Performance
- Advanced Glycation End Products research
Universidade Federal do Rio Grande do Sul
2009-2018
University of Groningen
2015-2018
University Medical Center Groningen
2015-2016
AZ Sint-Lucas
2016
Hôpital Sainte-Marguerite
2012
Phenylketonuria (PKU) was the first disorder in which severe neurocognitive dysfunction could be prevented by dietary treatment. However, despite this effect, neuropsychological outcome PKU still remains suboptimal and phenylalanine-restricted diet is very demanding. To improve relieve restrictions for patients, supplementation of large neutral amino acids (LNAA) suggested as alternative treatment strategy that might correct all brain biochemical disturbances caused high blood phenylalanine,...
Phenylketonuria (PKU) is characterized by phenylalanine (Phe) accumulation to toxic levels due the low activity of phenylalanine-hydroxylase. PKU patients must follow a Phe-restricted diet, which may put them in risk nutritional disturbances. Therefore, we aimed characterize body composition parameters and status Brazilian also considering their metabolic control. Twenty-seven treated older than 5 years, 27 age- gender-matched controls, were analyzed for anthropometric features bioelectrical...
To unravel the role of gene mutations in healthy and diseased state, countless studies have tried to link genotype with phenotype. However, over years, it became clear that strain mice can influence these results. Nevertheless, identical different strains are often still considered equals. An example this, is research done phenylketonuria (PKU), an inheritable metabolic disorder. In this field, a PKU mouse model (either on BTBR or C57Bl/6 background) used examine underlying mechanisms...
High phenylalanine levels in phenylketonuria (PKU) have been associated with brain oxidative stress and amino acid imbalance. Exercise has shown to improve function hyperphenylalaninemia neurodegenerative diseases. This study aimed verify the effects of exercise on coordination balance, plasma levels, markers PKU mice.Twenty wild-type (WT) 20 PAH(enu2) C57BL/6 mice were placed cages (exercise, Exe) or without (sedentary, Sed) running wheels during 53 days. At day 43, a balance beam test was...
In phenylketonuria, dietary treatment prevents most of the severe brain disease. However, patients have to follow a diet restricted in several natural components, what may cause decreased bone density and obesity. Exercise is known improve both mental functioning also avoiding obesity, could optimize aspects central peripheral outcome, regardless changes phenylalanine (Phe) levels. acute effects exercise on metabolic parameters phenylketonuria are unknown thereby long-term adaptations...
INTRODUÇÃO: A fenilcetonúria (PKU) é caracterizada pela deficiência da enzima fenilalanina hidroxilase, causando acúmulo de fenilalanina. O diagnóstico precoce e a subordinação à dieta pobre em são importantes para prevenir os efeitos prejudiciais hiperfenilalaninemia. Não aderir estritamente provoca, entre outros efeitos, um desequilíbrio aminoácidos neutros que usam o mesmo transportador na barreira hematoencefálica, causando, então, diminuição entrada triptofano, precursor serotonina no...
Para nadadores recreacionais (NR) ha poucas informacoes sobre relacoes cinematicas do nado, geralmente, pesquisas sao realizadas com atletas de elite. Objetivo: verificar comprimento medio bracada (CB), corrigido pela envergadura (CBc), frequencia media (FB) e velocidade (VN) nado crawl sob diferentes intensidades em NR. Participaram 24 individuos, separados nos grupos G1 G2, respectivamente, mulheres homens que nadam, aproximadamente, 3000 m por sessao, tres vezes semanais; G3 G4, 1000 duas...
FC), concentrações plasmáticas de triptofano [TRP], prolactina ([PRL]) e ácidos graxos livres ([AGL]). Catorze nadadores realizaram dois protocolos distintos: 1) repetições 200 400 m, em máxima intensidade (V200 V400) para a determinação da VC; 2) série VC (repetições m), com intervalos 40 s.Os principais resultados foram: ( [TRP] [AGL] não apresentaram diferenças entre repouso exaustão (p > 0,05); (2) aumento [PRL], [LA], FC do EP < 0,05) ao longo VC.Assim o [PRL] pode indicar manifestação...
Animal studies provide valuable insight into the effects of exercise on brain, but few voluntary resistance and ‘‘couch potato’’ models are available. We tested novel methods to induce physical inactivity or strength training in mice their brain functioning. Resistance running burrowing were as methods. Physical was induced by housing small cages prohibiting lid-climbing. The these interventions (~10 weeks) fitness body composition assessed. In a subsequent experiment, we whether influenced...