Asthma is a complex multifactorial disease with an obvious genetic predisposition, immunological aberration, and involvement of noxious environmental factors. Polymorphisms the glutathione-S-transferase (GST) genes are known risk factors for some environmentally-related diseases. In present study, hypothesis that polymorphisms in GSTT1, GSTM1 GSTP1 associated atopic nonatopic asthma was examined.The study population consisted 103 unrelated healthy individuals 101 patients bronchial (64...

Recently, it has been shown that protein phosphatase 2A (PP2A) dysfunction was common in many cancer types and mediated by various inactivation mechanisms. Although research studies observed antitumor effect of propolis extracts cancer, the mechanism are still obscure. In this study, we investigated on PPP2R1A expression its relationship with apoptosis SW‐620 (colorectal cancer), DU‐145 PC‐3 (prostate MCF‐7 (breast cancer) cell lines, WI‐38 (healthy fibroblast) cells serving as control....

The enzyme of N-acetyltransferase (NAT) is involved in the metabolism and detoxification cytotoxic carcinogenic compounds as well reactive oxygen species (ROS). excessive amount ROS generation occurs ageing inner ear. exact etiopathogenesis presbycusis not known, but it generally accepted that result series insults, such physiologic age-related degeneration, noise exposure, medical disorders their treatment, hereditary susceptibility. effect aging shows a wide interindividual range; we aimed...

Abstract Glutathione S ‐transferases (GSTs) are enzymes involved in the metabolism of many disease‐causing electrophilic substrates and protect cells against oxidative stress. In present study, we investigated GSTM1 , GSTT1 GSTP1 gene polymorphisms diabetic patients healthy individuals searched whether GST genes associated with diabetes mellitus (DM) Turkish population. The study population consisted 98 unrelated DM. Genotyping was performed using real time polymerase chain reaction a Light...

The evaluation of oenological colorimetric indexes, CIELAB parameters, total phenols and antioxidant activities has been studied in different fruit wines made from black mulberry, blackberry, quince, apple, apricot, melon, red raspberry, bilberry, sour cherry strawberry.The highest value phenolic contents were determined blackberry mulberry (61.80%, 1161 mg/l gallic acid equivalents; 60.00%, 1232 58.10%, 1081 equivalents), respectively. values for A420 nm, A520 A620 the proportion blue, wine...

Propolis has a lots of properties related to human health: antioxidant, antimicrobial, antiseptic, antibacterial, anti-inflammatory, antimutagenic, and immunomodulating. Its possible effects on different cancers are among the priorities these properties. So, in this study, comparative cytotoxic biotransformed propolis samples colon cancer cells healthy epithelium were investigated. Before starting extraction procedure, done by using solvents (ethanol; poly-ethylene glycol - PEG; water )...

Beer is one of the most popular beverages in world, so developing new flavors and increasing nutritional value beer production critical. In study green tea, rosemary grape pomace were used as alternatives to hops. The total phenolic flavonoid content beers obtained by adding tea was found be higher than that those made with hops (p<0.05). discussed values black similar produced had antioxidant activity hop-based beers, but lower According our data, use plants rich bioactive components...

Summary The highest values of antioxidant activity (AOA), inhibition low‐density lipoproteins (LDL‐diene, LDL‐MDA) and total phenols were determined in pomace (82.30 82.60%), grapes (68.91%) must [2750 mg L −1 gallic acid equivalents (GAE)], respectively. For all parameters (AOA, iLDL‐diene, iLDL‐MDA, phenols) the obtained Cabernet Sauvignon Merlot grape varieties. Positive correlations between AOA iLDL‐diene ( r = 0.809); 0.528); 0.451) with significance P < 0.005. results principal...

Glutathione S-transferases (GSTs) belong to a superfamily of detoxification enzymes that provide critical defences against large variety chemical carcinogens and environmental toxicants. GSTs are present in most epithelial tissues the human gastrointestinal tract. We investigated associations between genetic variability specific GST genes (GSTM1, GSTT1 GSTP1), interaction with cigarette smoking susceptibility gastric cancer. The GSTM1, GSTP1 polymorphisms were determined using real-time...

Purpose: Rosacea might be related to an increased activity of reactive oxygen species (ROS) and deficient function the antioxidant system. Glutathione S‐transferases (GSTs) play a primer role in cellular defense against electrophilic chemical radical species. We hypothesized that ROS or decreased potential, possibly induced by GST gene polymorphism, have pathogenic rosacea. Methods: The study group consisted 45 patients with rosacea 100 control subjects. DNA samples were isolated from blood...

The aim of this study was to compare in vitro gas production kinetics, metabolizable energy (ME), organic matter digestibility (OMD) and microbial protein (MP) widely used legume hays ruminant nutrition Turkey.Gas were determined at 0, 3, 6, 12, 24, 48, 72 96 h their kinetics described using the equation p = a+b (1-e -ct ).There significant differences among terms chemical composition.The crude content ranged from 11.7 18.6% dry (DM); fat 2.1 3.5% DM; neutral detergent fiber 35.6 52.0% acid...

Studies were conducted to determine the effects of different ensiling densities on fermentation, aerobic stability, and nutritive value maize sorghum silages. Maize harvested at dough (363 g/kg) milk stages (275 g/kg), respectively. Herbages chopped approximately 1.5 cm after harvest then ensiled in mini silos high low-bulk for 8.5 weeks. Different bulk achieved by weights herbage fixed-volume (1.5-L anaerobic jars, Weck, Germany). The obtained dry matter (DM) 168 216 kg DM/m3 forage 132 178...

Relationships between poor prognosis of ovarian malignancies and changes in complete blood count parameters have been proposed previously. In this work, we aimed to evaluate clinicopathologic features adolescents with adnexal masses sought establish any predictive value the platelet lymphocyte ratio (PLR) diagnosis.This retrospective study was conducted on 196 adolescent females masses. Three groups were constituted respect clinical or histopathology results: group 1, non-neoplastic patients...

The quality of wine depends on many factors. One the most important is selection appropriate and defined grape varieties. analysis phenolic compounds, amino acids, trace elements isotopes wines, used for identification grapes varieties, not sufficient requires a lengthy period. development molecular techniques such as restriction fragment length polymorphism, random amplified polymorphic DNA microsatellites provides opportunities differentiation In this regard, use extracted from must...

Sulfur dioxide (SO2) is the most common additive used in winemaking for many years. This compound important wine producers and consumers due to its antiseptic antioxidant properties. However, excessive sulfites caused some symptoms such as a headache, nausea, stomach irritation respiratory distress asthmatic patients. Additionally, SO2 process leads organoleptic changes of final product. For these reasons, maximum concentrations allowed wines were gradually reduced. In industry it essential...

HIGHLIGHTS The effects of different extraction methods on bioactive compounds propolis. highest antioxidant activity was obtained by ultrasound application. phenols and esters were microwave-assisted method.

Current research suggests that phenolics from wine may play a positive role against oxidation of low-density lipoprotein (LDL), which is key step in the development atherosclerosis. Considering effects different wine-making techniques on phenols and consumption preference influencing benefical product, organically non-organically produced wines were obtained grapes Vitis vinifera origin var: Carignan, Cabernet Sauvignon, Merlot, Grenache, Columbard Semillon. Levels total [mg/l gallic acid...

Maceration and fermentation time temperatures are important factors affecting wine quality. In this study different maceration times (3 6 days) (15 ℃ 25 ℃) during production of red ( Vitis vinifera L. Cabernet Sauvignon) were investigated. all wines standard chemical parameters some specific as total phenols, tartaric esters, flavonols colour (CD, CI, T, dA%, %Y, %R, %B, CIELAB values) determined. Sensory evaluation was performed by descriptive sensory analysis. The results demonstrated not...

Bu arastirma, yonca (Medicago sativa L.) silajinda karbonhidrat kaynagi olarak kullanilan gladicya meyvesi (GM)’nin laboratuvar kosullarinda yapilan silajlarin fermantasyon, aerobik stabilite, in vitro gaz uretimi, mikrobiyolojik ozellikleri uzerindeki etkilerinin saptanmasi amaci ile yapilmistir. Arastirmada tam ciceklenme doneminde hasat edilmis ve yaklasik 1.5-2.0 cm boyutunda dogranan taze materyale 0 (kontrol), 20, 40, 60, 80 100 g/kg KM duzeyinde GM katilmistir. Yoncaya ilavesi, elde...