A5011733026- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Biochemical and Molecular Research
Lund University
2018-2025
Ethiopian Public Health Institute
2018-2025
Dolutegravir-based antiretroviral therapy (ART) has been scaled up in many developing countries, including Ethiopia. However, subtype-dependent polymorphic differences might influence the occurrence of HIV-drug-resistance mutations (HIVDRMs). We analyzed prevalence pre-treatment integrase strand transfer inhibitor (INSTI) HIVDRMs and naturally occurring polymorphisms (NOPs) gene, using plasma samples collected as part national HIVDR survey Ethiopia 2017. included a total 460 HIV-1 gene...
HIV drug resistance (HIVDR) presents a significant challenge to antiretroviral therapy (ART) success, particularly in resource-limited settings like Ethiopia. This cross-sectional study investigated viral suppression rates and patterns among patients on second-line ART across 28 Ethiopian health facilities. Blood samples collected from 586 participants were analyzed measure CD4 count load assess HIVDR experiencing virological failure (VF) (viral ≥ 1000 copies/mL). Demographic clinical data...
Background The HIV-1 epidemic in Ethiopia has been shown to be dominated by two phylogenetically distinct subtype C clades, the Ethiopian (C'-ET) and East African (C-EA) however, little is known about temporal dynamics of HIV with respect subtypes clades. Moreover, there only limited information concerning transmission drug resistance (TDR) country. Methods A cross-sectional survey was conducted among young antiretroviral therapy (ART)-naïve individuals recently diagnosed infection, Gondar,...
To determine viral load (VL) nonsuppression (VLN) rates, HIV drug resistance (HIVDR) prevalence, and associated factors among female sex workers (FSWs) in Ethiopia.A cross-sectional biobehavioral survey was conducted FSWs 11 cities Ethiopia 2014. Whole blood collected, HIVDR genotyping performed. Logistic regression analysis performed to identify with VLN HIVDR.Among 4900 participants, 1172 (23.9%) were HIV-positive 1154 (98.5%) had a VL result. Participants categorized into antiretroviral...
Background: The use of surrogate markers for targeting viral load (VL) testing could be an alternative to universal VL during antiretroviral treatment (ART) and would allow more effective resource allocation. We investigated the correlation between levels HIV RNA interferon-γ–inducible protein 10 (IP-10) in Ethiopian adults at 12 months after ART initiation. In addition, we specifically differences IP-10 patients with without virological suppression. Setting: Cohort HIV-positive receiving...
Ethiopia is one of the sub-Saharan countries hit hard by HIV epidemic. Previous studies have shown that subtype C dominates Ethiopian HIV-1 epidemic, but evolutionary and temporal dynamics in not been closely scrutinized. Understanding epidemiological pattern vital to monitor spread, evaluate implement prevention strategies. We analyzed 1,276 polymerase (pol sequences), including 144 newly generated sequences, collected from different parts country 1986 2017. employed state-of-art maximum...
Abstract Background Evidence on the distribution of pre-treatment HIV-1 drug resistance (HIVDR) among risk groups is limited in Africa. We assessed prevalence, trends and transmission dynamics HIVDR within between MSM, people who inject drugs (PWID), female sex workers (FSWs), heterosexuals (HETs) perinatally infected children Kenya. Methods partial pol sequences from antiretroviral-naive individuals collected multiple sources 1986 2020 were used. Pre-treatment reverse transcriptase...
Abstract Background The increasing prevalence of antiretroviral drug resistance in Sub-Saharan Africa threatens the success HIV programs. We have characterized patterns mutations (DRMs) during initial year treatment (ART) HIV-positive adults receiving care at Ethiopian health centers and investigated impact tuberculosis on DRM acquisition. Methods Participants were identified from a cohort ART-naïve individuals aged ≥18 years, all whom had been for active inclusion. Individuals with viral...
ABSTRACT Background Evidence on the distribution of pre-treatment HIV-1 drug resistance (HIVDR) by risk groups is limited in Africa. We assessed prevalence, trends, and transmission dynamics HIVDR within-and-between men who have sex with (MSM), people inject drugs (PWID), female workers (FSW), heterosexuals (HET), children infected perinatally Kenya. Methods partial pol sequences from antiretroviral-naïve samples collected between 1986-2020 were used. Pre-treatment RTI, PI INSTI mutations...