Background: Currently, many approaches to PMI estimation focus on observable and measurable changes the body after death. These gross occur because of at cellular level. Degenerative post-mortem epithelium connective tissue in oral mucosa may demonstrate specic patterns that could prove useful determine PMI. The present study i Aim Objectives: s aimed characterise time-wise histological tissues autopsy. 50 mucosal sa Materials Method: mples each form buccal were collected during Tissues...

<br><b>BACKGROUND:</b> The B cell lymphoma-2 gene is a proto-oncogene whose protein product inhibits apoptosis. Its role associated with keeping cells alive, but not by stimulating them to proliferation, as other proto-oncogenes do. Increased expression of Bcl-2 appears in the early phase carcinogenesis leading apoptosis impairment and consequence progression neoplastic changes. <b>OBJECTIVE:</b> To evaluate compare oral epithelial dysplasia squamous carcinoma (OSCC). <b>MATERIALS AND...

Determination of age a subject is one the most important aspects medico-legal cases and anthropological research. Radiographs can be used to indirectly measure rate secondary dentine deposition which depicted by reduction in pulp area.In this study, 200 patients Karnataka aged between 18-72 years were selected for study. Panoramic radiographs made digitized. Radiographic images maxillary canines (RIC) processed using computer-aided drafting program (ImageJ). The variables pulp/root length...

Forensic odontology is a branch that evolving over time and has opened newer avenues may help in the identification of individuals. Tooth prints are enamel rod end patterns on tooth surface they considered as hard tissue analog to fingerprints. Teeth have highest resistance most environmental effects like fire, desiccation, decomposition, be used forensic evidence.The aim study was evaluate if could for an individual's reproducibility permanency these after exposing teeth acid various...

Grafting in oral implantology involves bone augmentation procedures with various graft materials. Success of such is evaluated through the amount volume and formed at grafted site. The primary aim this prospective study was to histomorphometrically evaluate compare new formation Bio Oss or Cerabone lateral approach sinus procedure.The research targeted 22 patients who were either partially completely edentulous posterior maxilla residual alveolar height 3 mm site implantation underwent a two...

ABSTRACT Background and Objectives: CD56, associated with neuroectodermal differentiation of the embryonal cells, is often considered a marker neural lineage. Odontogenic keratocysts (OKCs) are particular interest because their characteristic histopathologic features, high recurrence rate, aggressive behavior. CD56 immunoreactivity in these lesions has been reported very frequency. The present study analyzes immunoexpression ameloblastoma (AM) OKC to infer influence pathogenesis odontogenic...

Oxidative stress has been implicated in tumourigenesis by affecting the actions of various protein kinases and transcription factors, resulting damage to DNA structure deamination nucleotides generation free radicals. Derangements antioxidant defence mechanism have considered pathogenesis oral cancer.To evaluate compare serum levels nitric oxide vitamin C cases Oral Potentially Malignant Disorders (OPMDs) Squamous Cell Carcinoma (OSCC) healthy controls.Serum from 20 patients with OSCC, OPMDs...

(2020). Staining efficacy assessment of a differential routine and special stains for pathological stromal calcifications in maxillofacial lesions. Journal Histotechnology: Vol. 43, No. 3, pp. 118-124.

Identification and differentiation of stromal hard tissue components is a challenging task. Numerous methods demonstrating these have been worked upon in the past. Although some successful, there are many drawbacks employing them. The need hour, therefore to develop use simple, rapid cost-effective method identifying tissues as they may signify an important change diagnosis pathology. Our aim observe usability tetrachromic VOF stain over Hematoxylin Eosin Masson's Trichrome routinely...

The term oral potentially malignant disorder (OPMD) was recommended to refer precancer as it conveys that not all disorders described under this may transform into cancer. Oral squamous cell carcinoma (OSCC) arises through an accumulation of genetic alterations, deoxy ribonucleic acid (DNA) changes, and epigenetic alterations. Thus, a simple yet sensitive specific test for early diagnosis is the need hour. micronuclei (MN) assay in exfoliated epithelial cells excellent biomarker detect...

Oncogenes and tumor suppressor genes play a major role in cancer formation, growth, progression. One of the important findings this area is that murine double minute 2 (MDM2) oncogene negative regulator wild-type p53. In tumors, expressing p53, inhibition MDM2 expression will stabilize p53 allow it to perform its proapoptotic function, while simultaneously preventing from exerting p53-independent oncogenic effects. The intracellular levels are tightly regulated by MDM2, as key player...

This split-mouth clinical study aimed to investigate levels of alpha-2-macroglobulin (a2M) in gingival crevicular fluid (GCF) chronic periodontitis patients pre- and post-scaling root planing (SRP) with or without adjunctive use tetracycline fibers.In 30 periodontitis, samples GCF were collected from the sulcus before SRP. Recording parameters was conducted. followed by local drug delivery (LDD) fibers test sites. In control sites, no LDD done. Second taken 90 days after treatment. Samples...

Background: Salivary gland tumors bear uncanny characteristics of being different based on their morphological aspects rather than the presence clear demarcation. This ambiguity in spectrum from benign to malignant salivary neoplasms while categorizing neoplasm is having inherent pitfalls. The present study was, therefore, designed characterize and proliferative indices. Materials Method: Study samples comprised 97 cases histopathologically confirmed tumors. were immunohistochemically...

Background: Increased iron overload is frequent problem in thalassemia patients, and this monitored by serum ferritin levels or chemical assessment of the liver tissue. However, repeated monitoring to assess an invasive procedure associated with practical problems. Aims: To use Perl's Prussian blue reaction evaluate beta-thalassemia patients staining oral cytosmears. Materials Methods: The study comprised 35 diagnosed beta-thalassemia. Cytosmears were prepared from exfoliated epithelial...

Ameloblastoma is true odontogenic tumor of epithelial origin, which described as locally aggressive with varying chances recurrence. It believed to derive from enamel organ, remnants dental lamina, lining cysts, or basal cells oral epithelium. Radiologically, it may present unilocular multilocular radiolucency commonly. Although conventional ameloblastoma presents typical histological features by Vickers and Gorlin, few unusual variants have been reported different patterns. However, the...

To evaluate and compare the leptin levels in gingival crevicular fluid (GCF) rate of canine retraction using an elastomeric chain nickel-titanium (NiTi) closed coil spring.In vivo, clinical study.Orthodontic department at ITS Centre for Dental Studies Research, Ghaziabad, India.Twenty-seven patients reported to Department Orthodontics Research.Twenty-seven were included study which was carried out with NiTi spring on either side arch applying 150 g force both sides. GCF samples collected...

The aim of the present study was to correlate immunoexpression alpha-smooth muscle actin (α-SMA) for myofibroblasts with serum levels transforming growth factor-β1 (TGF-β1) in oral submucous fibrosis (OSMF).A total 100 cases histopathologically confirmed OSMF were assessed α-SMA expression. Clinical data, such as age, sex, mouth opening, and habit history, obtained each case. Serum TGF-β1 recorded 73 patients help enzymelinked immunosorbent assay technique.The staining index increased...

Tooth carving is an important practical preclinical exercise in the curriculum Indian dental education setup. It forms basis of introduction to tooth anatomy, morphology and occlusion primary permanent teeth through approach. requires enormous time manpower master skill. Therefore, there imminent necessity incorporate computer-based learning art for effective teaching efficient student learning. This will ensure quality be spent on other academic research activities by students faculty...

Previous studies have shown that Hydroxyapatite (HA) has good results in the treatment of intra-osseous periodontal defects. A newer variety HA been designed over a period research which nano-sized particles and is availed paste consistency called Nanocrystalline (NHA paste). This variation size surface area NHA can provide better when used intra-bony defects.The purpose this study was to compare clinical radiographic outcomes obtained with usage those Demineralized Bone Matrix (DBM)...

Introduction: Breast carcinoma is the most common cancer among women in both developing and developed countries.It needs alarming attention because it causes high morbidity mortality.There a need to understand initiation progression of breast on hormonal, cellular molecular basis which forms platform for designing targeted therapy.This study was intended find correlation between expression Estrogen receptor, Progesterone receptor Human Epidermal Growth Factor Receptor-2 with histological...

Epithelial-mesenchymal transition (EMT) is a complex process, in which epithelial cells acquire the characteristics of invasive mesenchymal cells. EMT has been implicated cancer progression and metastasis as well formation many tissues organs during development.The aim study was to ascertain role hypoxia-mediated signaling pathways influencing angiogenesis oral submucous fibrosis (OSMF).Evaluation immunoexpression alpha-smooth muscle actin (α-SMA), E-cadherin, vimentin, factor VIII receptor...

ABSTRACT Background: Indistinct and analogous histopathological features of various fibro-osseous lesions make establishing a definitive diagnosis challenge. There is need for additional molecular histochemical tools to support differentiate these in order establish concrete diagnosis. Materials Methods: A retrospective analysis biopsied formalin-fixed paraffin-embedded sections (10 cases each fibrous dysplasia, ossifying fibroma, cement-osseous dysplasia) retrieved from the archives was...