A5101481059- Ion Channels and Receptors
- Oral microbiology and periodontitis research
- Biochemical Analysis and Sensing Techniques
- Educational Robotics and Engineering
- Dental Health and Care Utilization
- Phytochemicals and Antioxidant Activities
- Periodontal Regeneration and Treatments
- Olfactory and Sensory Function Studies
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Postharvest Quality and Shelf Life Management
- Essential Oils and Antimicrobial Activity
- Piperaceae Chemical and Biological Studies
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- dental development and anomalies
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Dental Radiography and Imaging
- Salivary Gland Disorders and Functions
- Enzyme Catalysis and Immobilization
- Immune Response and Inflammation
- Dental Erosion and Treatment
- Toxin Mechanisms and Immunotoxins
- Dental Research and COVID-19
Tottori University
2009-2024
University of Shizuoka
2011-2021
Food & Nutrition
2003-2021
Okayama University
1997-2020
Kyoto University
1985-2015
Eisai (Japan)
2014
The University of Tokyo
1982-2013
Kogakuin University
2010-2012
American Dental Hygienists' Association
2012
Weatherford College
2011
E7080 is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. In this study, we show the inhibitory activity against SCF-induced angiogenesis in vitro tumor growth SCF-producing human small cell lung carcinoma H146 cells vivo. inhibits SCF-driven tube formation HUVEC, which express receptor, KIT at IC(50) value 5.2 nM it was almost identical for VEGF-driven one (IC(50) = 5.1 nM). To assess role SCF/KIT signaling angiogenesis, evaluated...
Lenvatinib is an oral inhibitor of multiple receptor tyrosine kinases (RTKs) targeting vascular endothelial growth factor (VEGFR1-3), fibroblast (FGFR1-4), platelet α (PDGFR α), RET and KIT. Antiangiogenesis activity lenvatinib in VEGF- FGF-driven angiogenesis models both vitro vivo was determined. Roles tumor vasculature (microvessel density (MVD) pericyte coverage) as biomarkers for were also examined this study.We evaluated antiangiogenesis against proliferation tube formation HUVECs...
The mode of action capsaicin on energy metabolism was investigated in rats. oxygen consumption higher when (6.0 mg/kg) intraperitoneally injected than it not injected. respiratory quotient (R.Q.) increased and then decreased after the administration capsaicin. levels serum glucose immunoreactive insulin rapidly Also, liver glycogen decreased, contrast to concentration which increased. serum-free fatty acid level gradually These alterations were similar those epinephrine, specifically...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNovel Capsaicinoid-like Substances, Capsiate and Dihydrocapsiate, from the Fruits of a Nonpungent Cultivar, CH-19 Sweet, Pepper (Capsicum annuum L.)Kenji Kobata, Tomoko Todo, Susumu Yazawa, Kazuo Iwai, Tatsuo WatanabeView Author Information School Food Nutritional Sciences, University Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan, Graduate Agriculture, Kyoto University, Oiwake-cho, Kitashirakawa, 606-8585, Faculty Home Economics, Kobe Women's...
The molecular composition of progenitor toxins produced by a Clostridium botulinum type A strain (A-NIH) was analyzed. three types (19 S, 16 and 12 S) as reported previously. Purified 19 S demonstrated the same banding profiles on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), indicating that they consist protein components. nontoxic components are non-hemagglutinin (HA) (molecular mass, 120 kDa) HA. HA could be fractionated into five subcomponents with masses 52, 35,...
Summary There has been interest in biological activities of green tea catechins. However, little is known about the taste characteristics To assess catechins ((−)–epicatechin (EC), (−)–epicatechin gallate (ECg), (−)–epigallocatechin (EGC) and (EGCg)), sensory evaluations were performed. The intensity increased with concentration. Among them, ECg showed strongest taste. Catechins had tastes that consisted primarily astringency bitterness. Therefore, palatability decreased increasing catechin...
We investigated the effects of a single oral administration capsiate, which is found in fruits non-pungent cultivar pepper, CH-19 Sweet, and has same structure as capsaicin except for replacement NH by O alkyl chain, on thermogenesis fat accumulation mice. The oxygen consumption serum adrenalin concentration were higher both (10 mg/kg-body weight) capsiate groups than those control group. also examined 2 weeks body accumulation. Eevery day (10, 50 weight/day) markedly suppressed well...
Eight hundred forty-nine Japanese dentists were asked to record the reason for every tooth extraction of permanent teeth during 1 week in each four seasons. The reasons assigned six groups: dental caries, periodontal disease, eruption problems, trauma, orthodontics and other reasons. Thirty-eight 40% returned forms season, relating a total 11,175 extracted teeth. Overall, caries was most frequent (55.4%), followed by disease (38.0%). females lost more due than did males. In > or = 16 age...
This study aimed (1) to investigate the influences of sex, age and number teeth on biting ability through a descriptive survey, (2) compare between subjects with without mobile in case-control study. A total 687 cooperated survey. Each subject bit pressure detecting sheet their maximum force. Three indices ability: (MPa), force (N) occlusal contact area (mm2) were calculated from impressed marks using high vision video processor system. These correlated well according multiple regression...
Capsaicin enhances adrenal medullary catecholamine secretion. The participation of the central nervous system on this enhancement by capsaicin was investigated in alpha-chloralose-urethan- or halothane-anesthetized rats. Intravenous administration caused a rapid and marked increase sympathetic nerve activity. activity began to show an with at dosage 20 micrograms/kg significantly increased 200 micrograms/kg, i.e., found cause dose-dependent Cholinergic blocking hexamethonium bromide atropine...
We searched in this study for novel agonists of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and A, (TRPA1) pepper, focusing attention on 19 compounds contained black pepper. Almost all the HEK cells heterogeneously expressed TRPV1 or TRPA1, increased intracellular Ca(2+) concentration ([Ca(2+)](i)) a concentration-dependent manner. Among these, piperine, isopiperine, isochavicine, piperanine, pipernonaline, dehydropipernonaline, retrofractamide C, piperolein B...
We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All gingerols increased intracellular calcium concentration rat transient receptor potential vanilloid subtype 1 (TRPV1)-expressing HEK293 cells via TRPV1. In this regard, more potent than gingerols. Aversive responses induced by [6]-, [10]-gingerol, [6]-shogaol (5 mmol/l) rats...
Thermosensitive transient receptor potential (TRP) channels, especially TRPV1 and TRPA1, are activated by the pungent compounds present in spices. activation intake of capsaicin, irritant hot pepper, induces adrenaline secretion increases energy consumption. is mainly expressed sensory neurons coexpressed with TRPA1 at a high frequency. However, mechanism underlying agonists such as allyl isothiocyanate (AITC) cinnamaldehyde (CNA), ingredients mustard cinnamon, not known. We examined whether...
Capsaicinoids are responsible for the spicy flavor of pungent peppers (Capsicum). The cultivar CH-19 Sweet is a non-pungent pepper mutant derived from strain, Capsicum annuum CH-19. biosynthesizes capsaicinoid analogs, capsinoids. We determined genetic and metabolic mechanisms capsinoid biosynthesis in this cultivar. analyzed putative aminotransferase (pAMT) that thought to catalyze formation vanillylamine vanillin biosynthetic pathway. Enzyme assays revealed pAMT activity catalyzing was...
This is the first report of TRPA1 activation by fatty acids. Activation and TRPV1 induces thermogenesis energy expenditure enhancement. In this study, we searched for novel agonists from a nonpungent food, royal jelly (RJ). We measured human RJ extracts found that hexane extract contains agonists. The main functional compounds in were trans-10-hydroxy-2-decenoic acid (HDEA) 10-hydroxydecanoic (HDAA). These are characteristic acids RJ. Their EC50 values about 1,000 times larger than AITC,...
A new capsiate-like substance, named nordihydrocapsiate (1), has been isolated from the fruits of a nonpungent cultivar, CH-19 Sweet, pepper (Capsicum annuum). The structure 1 was determined to be 4-hydroxy-3-methoxybenzyl 7-methyloctanoate by spectroscopic methods.
This study investigated the masticatory rehabilitation of subjects wearing different types prostheses. Biting abilities per person (biting force, biting pressure and occlusal contact area) were assessed with a detecting sheet (Prescale®). Five hundred ninety volunteers divided into four groups according to type posterior dentition: complete denture, removable partial fixed full natural dentition groups. The forces partial, denture wearers 80, 35 11% respectively, when expressed as percentage...
The detection threshold and taste characteristics of sanshools were examined by sensory evaluation, after isolating four (α-, β-, γ-, δ-), two hydroxy (α- β-) from the pericarp Japanese pepper. Scoville unit (SU) values in range 80,000–110,000, while those 3–5 fold lower than corresponding sanshools. pungent qualities each sanshool different. Burning tingling predominantly perceived lasted for longest time with α-sanshool. fresh γ-sanshool, numbing α-sanshool perceived. Tests on activation...
alpha-Melanocyte-stimulating hormone (alpha-MSH1-13) and its COOH-terminal tripeptide alpha-MSH11-13 (Lys Pro Val) inhibit inflammation when administered systemically. Recent evidence indicates that alpha-MSH1-13 can likewise in the skin solely via an action within brain. Because of potential importance this discovery to understanding control because alpha-MSH molecules might be useful for treatment inflammation, experiments were performed learn more about mechanisms these peptides. In tests...