A5009617850- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Abdominal Surgery and Complications
- Asymmetric Hydrogenation and Catalysis
- Cystic Fibrosis Research Advances
- Vestibular and auditory disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- X-ray Diffraction in Crystallography
- Balance, Gait, and Falls Prevention
- Parkinson's Disease Mechanisms and Treatments
- Dysphagia Assessment and Management
- Crystallization and Solubility Studies
- Neurological disorders and treatments
- Microbial infections and disease research
- Mechanical Failure Analysis and Simulation
- Stroke Rehabilitation and Recovery
- Gastric Cancer Management and Outcomes
- Injury Epidemiology and Prevention
- Catalytic Cross-Coupling Reactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Uterine Myomas and Treatments
- Cyclopropane Reaction Mechanisms
Phoenix Children's Hospital
2025
Indian Institute of Science Education and Research Mohali
2020-2024
University of Illinois Chicago
2014-2023
Albany Medical Center Hospital
2019-2023
Dr. D.Y. Patil Vidyapeeth, Pune
2022
University of British Columbia
2021
Northwestern Medicine
2021
Salford Royal Hospital
2019
Warwick Hospital
2019
University of Southern California
2005-2016
Objective Enlarged vestibular aqueduct (EVA) is the most common radiographic finding in children diagnosed with congenital sensorineural hearing loss (SNHL). Many institutions use Cincinnati criteria for diagnosis: width ≥2.0 mm at operculum and/or ≥1.0 midpoint. Our goals are to expand our understanding of EVA by examining audiometric and auditory brainstem response (ABR) characteristics a large population loss. Study Design Retrospective chart review. Setting Tertiary-care children's...
The development of the first intermolecular Rh2(II)-catalyzed aziridination olefins using anilines as nonactivated N atom precursors and an iodine(III) reagent stoichiometric oxidant is reported. This reaction requires transfer N-aryl nitrene fragment from iminoiodinane intermediate to a Rh2(II) carboxylate catalyst; in absence catalyst only diaryldiazene formation was observed. general can be successfully realized by little 1 equiv olefin. Di-, tri-, tetrasubstituted cyclic or acylic...
Parkinson's disease (PD) is a neurodegenerative that includes motor impairments, such as tremor, bradykinesia, and postural instability. Although eye movement deficits are commonly found in saccade pursuit tasks, preservation of oculomotor function has also been reported. Here we investigate specific task stimulus conditions under which PD preserved. Sixteen patients 18 healthy, age-matched controls completed battery tasks included stationary or moving targets eliciting reactive deliberate...
Abstract Background High‐intensity occupational therapy can improve arm function after stroke, but many people lack access to such therapy. Home‐based therapies could address this need, they don’t typically abnormal muscle co‐activation, an important aspect of impairment. An earlier study using lab‐based, myoelectric computer interface game training enabled chronic stroke survivors reduce co‐activation and function. Here, we assess feasibility doing at home a novel, wearable, for...
Fatigue is a debilitating symptom in patients with cystic fibrosis (CF). Although fatigue commonly reported these patients, an effective treatment for this has not been found. The factors associated CF have investigated. We conducted prospective, case–control study adult CF. All the were chronically infected Pseudomonas aeruginosa and enrolled during disease stability. A gender age-matched control group was also recruited. Subjective assessment included three questionnaires: Chalder...
The US incarcerates more individuals than any other country. Prisoners are the only population guaranteed health care by constitution, but little is known about their surgical needs. This multicenter study aimed to describe acute surgery (ACS) needs of incarcerated individuals.Twelve centers prospectively identified patients evaluated in emergency department ACS service. Centers collected diagnosis, treatment, and complications from chart review. Patients were classified as either general...
Abstract We report the Pd(II)‐catalyzed picolinamide‐aided ortho ‐C−H arylation‐, alkylation‐, and halogenation (sp 2 γ −C−H functionalization) of phenylglycinol substrates. Phenylglycinols are remarkable building blocks have found different applications in synthetic organic medicinal chemistry. This work is a contribution towards expansion library scaffolds also substrate scope development by using bidentate directing group C−H activation tactic.
The development of the first intermolecular Rh<sub>2</sub>(II)-catalyzed aziridination di-, tri-, or tetraubstituted olefins using aryl- heteroaryl amines as nonactivated N-atom precursors and an iodine(III) reagent stoichiometric oxidant is reported. transfer to olefin stereospecific, chemo- diastereoselective produce <i>N</i>-aryl aziridine only amination product.
Pleuropulmonary Synovial Sarcoma is a rare lung cancer with prevalence of <1% among all cancers. Little known about the clinical presentation, disease process, and appropriate treatment. Here we present 9-year-old male who was taken to operating room for pleurodesis blebectomy due recurrent spontaneous pneumothorax. Final pathology showed bleb an associated mass positive synovial sarcoma.
Abstract We report the construction of C5‐indole unnatural amino acid derivatives via diastereoselective Pd(II)‐catalyzed prochiral β ‐C(sp 3 )‐H arylation racemic (DL), and enantiopure L‐ D‐carboxamides acids with 5‐iodoindoles. Independently, indole‐based compounds motifs are important small molecules in organic synthesis drug discovery research. This aimed to contribute enriching library derivatives. The examples motif‐installed comprising norvaline, phenylalanine, leucine, norleucine,...
An intramolecular iron-catalyzed nitroso ene reaction was developed to afford six- or seven-membered N-heterocycles from nitroarenes using an earth abundant iron catalyst and phenylsilane as the terminal reductant. The can be triggered little 3 mol % of iron(II) acetate 4,7-dimethoxyphenanthroline ligand. scope is broad tolerating a range electron-releasing electron-withdrawing substituents on nitroarene, ortho-substituent modified diastereoselectively construct benzoxazines,...
We report the case of a 36-year-old woman with erythrocytosis due to ectopic erythropoietin production by very large uterine leiomyoma. Awareness this uncommon condition is important so that correct diagnosis can be suggested prior surgery and radical resection avoided.
Abstract Parkinson’s disease (PD) is a neurodegenerative that includes motor impairments such as tremor, bradykinesia, and postural instability. Although eye movement deficits are commonly found in saccade pursuit tasks, preservation of oculomotor function has also been reported. Here we investigate specific task stimulus conditions under which PD preserved. Sixteen patients eighteen healthy, age-matched controls completed battery tasks included stationary or moving targets eliciting...
Background: Forced expiratory volume 1 second (FEV1) has traditionally been used as a readily available marker of health in adult cystic fibrosis (CF). However, due to the obstructive nature this disease, it is possible that lung hyperinflation could be more closely related disease severity than FEV1. The purpose study was determine if associated with quality life, functional status, and pulmonary exacerbations FEV1 patients CF. Methods: Sixty-eight CF were evaluated retrospective study. We...