A5101655790- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Chronic Kidney Disease and Diabetes
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Renin-Angiotensin System Studies
- Education and Learning Interventions
- T-cell and B-cell Immunology
- Genomics and Chromatin Dynamics
- Genomics, phytochemicals, and oxidative stress
- Genetic Syndromes and Imprinting
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Genetic Associations and Epidemiology
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Artificial Intelligence in Healthcare
- GDF15 and Related Biomarkers
- interferon and immune responses
Tehran University of Medical Sciences
2023-2025
University of Pennsylvania
2023
Isfahan University of Medical Sciences
2015-2023
Imam Khomeini Hospital
2023
Cancer Research Institute
2023
Regenerative Medicine Institute
2021
University of Tabriz
2020
SeraCare Life Sciences (United States)
2008
Ventana Research Corporation (United States)
1998
Peptide aptamers provide probes for biological processes and adjuncts development of novel pharmaceutical molecules. Such are analogous to compounds derived from combinatorial chemical libraries which have specific binding or inhibitory activities. Much as it is generally difficult determine the composition in a quantitative manner, determining quality characteristics peptide displayed vivo problematical. To help address these issues we adapted green fluorescent protein (GFP) scaffold...
In spite of huge efforts, chronic diseases remain an unresolved problem in medicine. Systems biology could assist to develop more efficient therapies through providing quantitative holistic sights these complex disorders. this study, we have re-analyzed a microarray dataset identify critical signaling pathways related diabetic nephropathy. GSE1009 was downloaded from Gene Expression Omnibus database and the gene expression profile glomeruli nephropathy patients those healthy individuals were...
This study aimed to identify key indicators for optimizing learning environments through the integration of artificial intelligence (AI) in curriculum design. A qualitative research design was employed, involving semi-structured interviews with 25 participants from Tehran, Iran. The included educators, researchers, and practitioners expertise AI education. Data collection continued until theoretical saturation achieved, were analyzed using thematic analysis aid NVivo software. identified...
Selection of stably expressing housekeeping genes (HKGs) is a crucial step in gene expression analysis. However, there are no universal HKGs for all experiments, and they should be determined by each biologic condition. The aim this study was to detect appropriate kidney cells cultured long-term hypoxia.Based on screening using microarray data available from omnibus database, set candidate were chosen assessed human hypoxic or normoxic conditions about 2 weeks time course manner. stability...
The omics technologies provide an invaluable opportunity to employ a global view towards human diseases. However, the appropriate translation of big data knowledge remains major challenge. In this study, we have performed quality control assessments for 91 transcriptomics datasets deposited in gene expression omnibus database and also evaluated publications derived from these datasets. This survey shows that drawbacks analyses reports studies are more common than one may assume. report is...
Abstract Diabetic nephropathy (DN), the leading cause of end-stage renal disease, has become a massive global health burden. Despite considerable efforts, underlying mechanisms have not yet been comprehensively understood. In this study, systematic approach was utilized to identify microRNA signature in DN and introduce novel drug targets (DTs) DN. Using microarray profiling followed by qPCR confirmation, 13 6 differentially expressed (DE) microRNAs were identified kidney cortex medulla,...
Despite the huge efforts, chronic kidney disease (CKD) remains as an unsolved problem in medicine. Many studies have shown a central role for transforming growth factor beta-1 (TGFβ-1) and its downstream signaling cascades pathogenesis of CKD. In this study, we reanalyzed microarray dataset to recognize critical pathways controlled by TGFβ-1.This study is bioinformatics reanalysis data. The GSE23338 was downloaded from gene expression omnibus (GEO) database which assesses mRNA profile TGFβ-1...
Despite enormous achievements in the production of high-throughput datasets, constructing comprehensive maps interactions remains a major challenge. Lack sufficient experimental evidence on is more significant for heterogeneous molecular types. Hence, developing strategies to predict inter-omics connections essential construct holistic disease.Here, as novel nonlinear deep learning method, Data Integration with Deep Learning (DIDL) was proposed interactions. It consisted an encoder that...
<b><i>Background:</i></b> Hypertensive nephropathy (HN) is a high-burden disorder and leading cause of end-stage renal disease. Despite huge investigations, the underlying mechanisms are yet largely unknown. Systems biology promising approach to providing comprehensive insight into this complex disorder. <b><i>Methods:</i></b> Proteome profiles kidney tubulointerstitium outer inner cortex from rat model HN were retrieved proteomics...
Background: Diabetic kidney disease has substantial burden and limited therapeutic options. An inadequate understanding of the complex gene regulatory circuits underlying this disorder contributes to insufficiency current treatment strategies. MicroRNAs (miRNAs) play a crucial role as regulators functionally related networks. Previously, mmu-mir-802-5p was identified sole dysregulated miRNA in both cortex medulla diabetic mice. This study aims investigate miR-802-5p disease. Materials...