A5007260378- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Porphyrin and Phthalocyanine Chemistry
- Advanced biosensing and bioanalysis techniques
- Mechanical Failure Analysis and Simulation
- Supramolecular Chemistry and Complexes
- Fungal Infections and Studies
- Histone Deacetylase Inhibitors Research
- Advanced Photocatalysis Techniques
- Endoplasmic Reticulum Stress and Disease
- Redox biology and oxidative stress
- ATP Synthase and ATPases Research
- Liver Disease Diagnosis and Treatment
- Supramolecular Self-Assembly in Materials
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- Fungal Biology and Applications
- Tryptophan and brain disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
- Energy Efficiency and Management
Fudan University
2022-2025
Southwest University
2019-2024
Shandong Academy of Sciences
2024
Qilu University of Technology
2023-2024
Yan'an University
2023
Tiangong University
2023
Taizhou University
2023
Beijing University of Chemical Technology
2020
Beijing Institute of Technology
2013
Tokyo University of Marine Science and Technology
2011
Abstract Carbon tetrachloride (CCl 4 )‐induced liver injury is predominantly caused by free radicals, in which mitochondrial function of hepatocytes impaired, accompanying with the production ROS and decreased ATP energy supply animals intoxicated CCl . Here we explored a novel therapeutic approach, transplantation therapy, for treating injury. The results showed that mitochondria entered through macropinocytosis pathway, thereby cell viability was recovered concentration‐dependent manner....
Changes in mitochondrial structure and function are mostly responsible for aging age-related features.Whether healthy mitochondria could prevent is, however, unclear.Here we intravenously injected the isolated from young mice into aged investigated mitotherapy on biochemistry metabolism animal behaviors.The results showed that heterozygous DNA (mtDNA) of both mouse coexisted tissues after administration, meanwhile, ATP content increased while reactive oxygen species (ROS) level...
Tumor mitochondria alter their functions to reprogram cell metabolism and then allow tumor cells rapidly proliferate in the hypoxic acidic microenvironment.However, roles of normal played progression are still unclear.Here we investigate mitochondrial effect on abnormal tumors, clarify why have undergo functional changes growth.The isolated from healthy mouse livers were intravenously injected into melanoma model mice with lung metastasis, growth, animal survival associated metabolic...
Self-assembled nanoparticles based on supramolecular-organic frameworks and temoporfin demonstrate improved photo cytotoxicity in vitro anti-tumor efficacy vivo due to a reduced aggregation-induced quenching effect.
A new amphiphilic acyclic cucurbit[n]uril (CB[n]) is designed and synthesized. This CB[n] could encapsulate pharmaceutical drugs via a host–guest interaction. Self-assembly of this forms spherical nanoparticles with diameters 91 nm in water. The self-assembled are capable delivering doxorubicin high efficiency. Cell experiments show that the doxorubicin-loaded can improve cellular uptake cytotoxicity by using MCF-7/ADR cell line. A549 tumor-bearing mouse model shows help overcome multidrug...
A novel organic acid-base-co-catalyzed conversion of styrylepoxides into [1,1'-biaryl]-3-carbaldehydes was realized under microwave irradiation. Styrylepoxides first underwent an acid-catalyzed Meinwald rearrangement followed by a tandem base-catalyzed Michael addition, aldol and aromatization sequence to generate [1,1'-biaryl]-3-carbaldehydes.
Today mitochondria are considered much more than a energy plant in cells. Mitochondrial transplantation therapy has been an active research area for treating mitochondria-associated diseases from animal studies to clinical trials. However, the specific mechanism involved anti-tumor activity of healthy remain be characterized. Here we investigate signal and gender difference mitochondrial against malignant melanoma. In study, administrated intact extracted mouse livers respectively mice...
Photodynamic theranostics/therapy (PDT) is a potential strategy for selectively imaging malignant sites and treating cancer via non-invasive therapeutic method. Photosensitizers, the crucial components of PDT, enable colocalization photons light, photon/light therapy in window 400–900 nm exhibits photocytotoxicity to tumor cells. Due their high biostability photocytotoxicity, nanophotosensitizers (NPSs) are much interest theranostics at present. NPS-activated transfer energy through...
To date, Alzheimer's disease (AD) has grown to be a predominant health challenge that disturbs the elderly population. Studies have shown mitochondrial dysfunction is one of most significant features AD. Transplantation therapy healthy mitochondria (mitotherapy), as novel therapeutic strategy restore function, proposed treat mitochondria-associated disease. Also, molecular mechanism mitotherapy remains unclear. Here, we applied in AD model mice induced by amyloid-β (Aβ) plaque deposition and...
Acyclic cucurbit[n]uril-based nanosponges are prepared based on supramolecular vesicle-templated cross-linking. The capable of encapsulating the clinically approved photodynamic therapeutic (PDT) drug temoporfin. When loaded with nanosponges, PDT bioactivity temoporfin is enhanced 7.5-fold for HeLa cancer cells and 20.8 fold B16-F10 cells, respectively. reason significant improvement in efficacy confirmed to be an cell uptake by confocal laser scanning microscopy flow cytometry. Animal...
This paper describes the design and synthesis of a conjugate, which is composed percarboxylated water-soluble pillar[6]arene three fluorescent pyrene chromophores on alternating methylene bridges. The optical characteristics are investigated. conjugate capable encapsulating polycationic guest spermine, results in an enhancement fluorescence intensity pyrene. host-pyrene used for direct sensing shows selectivity towards variety biological analytes. detection spermine demonstrated live cells.
Currently, cancer patients with microbial infection are a severe challenge in clinical treatment. To address the problem, we synthesized hemiprotonic compounds based on unique structure of nucleotide base pairs DNA i-motif. These were produced from phenanthroline (ph) dimerization as proton receptor and ammonium donor. The biological activity shows that have selective antitumor effect through inducing cell apoptosis. molecular mechanism could be related to specific inhibition transcription...
Glioma is the most aggressive and lethal brain tumor in humans. Mutations of mitochondrial DNA (mtDNA) are commonly found cells closely associated with tumorigenesis progress. However, glioma-specific inhibitors that reflect unique feature rare. Here we uncover RC-7, a ruthenium complex strong red fluorescence, could bind glioma mtDNA then inhibited growth human but not neuronal cells, liver, or endothelial cells. RC-7 significantly reduced energy production increased oxidative stress...
Colorectal cancer (CRC) is a common digestive tract tumor worldwide. Specific microorganisms, including Fusobacterium nucleatum (F. nucleatum) and Escherichia coli (E. coli), are abundant in colonic mucosa can promote the progression malignancy. Therefore, therapeutic strategy proposed to deliver effective drugs colorectum for both anticancer antibacteria. Here we used thin-film dispersion method encapsulate hemiprotonic phenanthroline-phenanthroline+ (ph-ph+) into nanomicelle. The results...
Cryptococcus neoformans (C. neoformans) is one of the most well-known zoonotic fungal pathogens. Cryptococcal encephalitis remains a major cause morbidity and mortality in immunocompromised hosts. Effective targeting killing C. brain an essential approach to prevent treat cryptococcal encephalitis. In this study, fluorescent polypyridyl ruthenium complex RC-7, {[phen2Ru(bpy-dinonyl)](PF6)2 (phen = 1,10-phenanthroline, bpy-dinonyl 4,4′-dinonyl-2,2′-bipyridine)}, was screened out, which showed...
Non-alcoholic liver injury (NLI) is a common disease worldwide. Since free radical damage in the crucial initiator leading to diseases, scavenging excess radicals has become an essential therapeutic strategy. To enhance antioxidant capacity of histidine, we synthesized protonated dimeric H-bihistidine, and investigated its anti-free potential several free-radical-induced NLI. Results showed that H-bihistidine could strongly scavenge caused by H2O2, fatty acid, CCl4, respectively, recover...