Plant-mediated green synthesis of nanomaterials has been increasingly gaining popularity due to its eco-friendly nature and cost-effectiveness. In the present study, we synthesized silver nanoparticles (AgNPs) by using an aqueous solution Saudi Origanum vulgare L. plant extract as a bioreducing agent. The as-synthesized AgNPs were characterized various microscopic spectroscopic techniques. results indicated formation crystalline face-centered cubic (fcc) AgNPs. Additionally, FT-IR study...

Due to their inexpensive and eco-friendly nature, existence of manganese in various oxidation states natural abundance have attained significant attention for the formation Mn3O4 nanoparticles (Mn3O4 NPs). Herein, we report preparation using nitrate as a precursor material by utilization precipitation technique. The as-prepared NPs) were characterized X-ray powder diffraction (XRD), UV–Visible spectroscopy (UV–Vis), High-Resolution Transmission electron microscopy (HRTEM), Field emission...

Green syntheses of metallic nanoparticles using plant extracts as effective sources reductants and stabilizers have attracted decent popularity due to their non-toxicity, environmental friendliness rapid nature. The current study demonstrates the ecofriendly, facile inexpensive synthesis silver (AP-AgNPs) extract aerial parts Anthemis pseudocotula Boiss. (AP). Herein, AP performed a twin role reducing well stabilizing agent. green synthesized AP-AgNPs were characterized by several techniques...

Our aim was to evaluate the association between expression and polymorphism of TLR4/NF-κB pathways colon cancer. TLR4 (rs4986790, rs10759932, rs10759931 rs2770150) were genotyped in blood samples from Colorectal patients healthy controls. cytokines inflammatory evaluated by real time PCR on 40 matching normal tissues protein level Immunohistochemistry. The high cancer is mainly due infections bacteria human leads induction an acute secretion mediated NF-κB. Also, we report here a clear...

The uncertainties in ZnO-mediated toxicity and particle stability a biological system remain challenge mitigate against deployment as next-generation nanoparticles (NPs), especially biomedical applications. With that perspective, the present study investigates surface chemical properties of ZnO NPs coated with three different surfactant biomolecules, namely polyethylene glycol (PEG), cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS) to control toxicity-induced potentials....

For the adsorption of sulfamethoxazole (SMX) and neodymium (Nd 3+ ) in mono- binary contaminant systems (SMX–Nd Nd –SMX), a novel composite was designed using sulfated fucan (FuS), MXenes, α-aminophosphonates (AMPs) this study.

Superoxide dismutase (SOD, EC 1.15.1.1) is an important metal-containing antioxidant enzyme that provides the first line of defense against toxic superoxide radicals by catalyzing their dismutation to oxygen and hydrogen peroxide. SOD classified into four metalloprotein isoforms, namely, Cu/Zn SOD, Mn Ni Fe SOD. The structural models soybean isoforms have not yet been solved. In this study, we describe for provide insights molecular function metal-binding in improving tolerance oxidative...

The herbal-based drug isolation-related research has increased recently around the globe. Accordingly, current study was designed to evaluate phytochemical content of ethanol extract Martynia annua and its chitosan nanoparticles (MA-CNPs) antibacterial activity against bacterial pathogens such as Bacteroides fragilis, Streptococcus oralis MTCC 2696, Propionibacterium acnes 1951, Pseudomonas aeruginosa 424, Staphylococcus aureus 2940, E. coli 443, Bacillus cereus 441, mutans 890, Aeromonas...

Endophytic fungi are widely known to reside in plant tissues causing no harm host plants or even noticeable change. They may colonize for a part of their life cycle complete the entire since provide variety novel metabolites. Despite being close relationship with medicinal plants, diversity and metabolic spectrum endophytic have not been researched well. Their ecological niche as symbionts make them attractive targets search biochemicals. We aimed isolate, purify, characterize fungal...

LncRNA Prostate cancer non-coding RNA (PRNCR1) is downregulated in many types of cancer. The current case-control study was performed on 144 patients with colorectal and 130 matching controls. Genotyping using TaqMan assays for four Single Nucleotide Polymorphisms (SNPs) PRNCR1. RNAsnp Web Server used to detect variations the secondary structure each SNP. genotyping analysis SNP rs1456315 showed increased association homozygous CC variant allele (OR: 2.09; χ2 = 4.95; CI: 1.08–4.02; p 0.02),...

Genetic polymorphism in long noncoding RNA (lncRNA) HOTAIR is linked with the risk and susceptibility of various cancers humans. The mechanism involved development CRC not fully understood but single nucleotide polymorphisms (SNPs) can be used to predict its prognosis. In present case-control study, we investigated relationship between (rs12826786, rs920778, rs1899663) Saudi population by genotyping using a TaqMan assay 144 cases age- sex-matched controls. We found significant (p < 0.05)...

Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), results in strikingly lower the T allele. In present study, we investigated whether this MMP-2 genetic might be associated susceptibility to colorectal cancer (CRC) Saudi population. We also analyzed gene expression level sin CRC patients and 4...

Background . DNA repair systems are essential for each cell to and maintain the genome integrity. Base excision pathway is one of crucial pathways integrity PARP-1 plays a key role in BER pathway. The purpose this study evaluate association between polymorphisms 3′untranslated region (3′UTR) SNP rs8679 its expression colorectal cancer. Methods Genotyping gene were performed using TaqMan assays. effects age, gender, tumor location evaluated cases controls regarding genotyping results....

Background: Genetic aberrations of DNA repair enzymes are known to be common events associated with different cancer entities. The aim the present study was analyze genetic associations rs1805404 (Asp81Asp) and rs1805414 (Ala284Ala) in PARP1 gene risk breast Saudi Arabia. Materials Methods: These two SNP's were analyzed a primary group patients healthy control subjects. Genotypes determined by TaqMan SNP testing using Chi-square or t test logistic regression analysis SPSS16.0 software....

Abstract Background Toll‐like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown. Therefore, we aimed to investigate polymorphisms risk Saudi population. Methods Three tag single‐nucleotide (rs2770150, rs10759931, rs4986790) were studied 222 unrelated patients with 190 healthy volunteers. Results We found that, over 60 years old, frequency TT genotype rs2770150 variant allele G rs10759931 higher...

Celiac disease (CD) is a gastrointestinal disorder whose genetic basis not fully understood. Therefore, we studied Saudi family with two CD affected siblings to discover the causal defect. Through whole exome sequencing (WES), identified that both have inherited an extremely rare and deleterious CPED1 variant (c.241 A > G; p.Thr81Ala) segregating as autosomal recessive mutation, suggesting its putative role in CD. population specific minor allele frequency (MAF) analysis has confirmed...

Background Colorectal cancer is the leading cause of cancer-related deaths in Saudi Arabia. Cancer has a multifactorial nature and can be described as disease altered gene expression. The profiling expression been used to identify subtypes predict patients' responsiveness. Telomere-associated proteins that regulate telomere biology are essential molecules development. Thus, present study examined their contributions colorectal progression patients. Methods hTERT, TRF1, TRF2, POT1, ATR, ATM,...

Genetic polymorphism in proinflammatory cytokine genes may be associated with the etiology of preterm birth (PTB). The current study was designed aim to explore association genetic polymorphisms and mRNA expression IL-1α, IL-1β, TNF-α gene Saudi population. Genotyping genomic DNA 50 PTB patients an equal number controls were carried out using TaqMan assay kits. Gene each quantitative RT-PCR. levels serum measured by ELISA. A statistically significant observed between rs361525 alleles (G...

Colorectal cancer (CRC) is a major health concern worldwide. A series of sequential accumulation genetic and epigenetic changes are responsible for the initiation progression diseases via normal > adenoma carcinoma sequence. Genetic variants in crucial cancer-causing genes known to mediate risk cancer. In this case-control study, we examined single nucleotide polymorphism (SNP) HER1 (rs763317 rs3752651) HER2 (rs1136201 rs1058808) assess their role susceptibility CRC Saudi population. TaqMan...

The sol-gel technique was adopted to synthesize the zinc oxide (ZnO) nanoparticles. Nano-sized ZnO particles are embedded in-situ poly(vinyl alcohol) (PVA) matrix form nanocomposite polymeric membranes. membranes were fabricated by varying concentration of nanoparticles 2.5, 5, and 10 wt.% in base PVA membrane matrix. crosslinked using tetraethyl orthosilicate (TEOS) followed hydrolysis co-condensation. Immersion a 2 molar sulphuric acid (H2SO4) bath produced sulfonated characterized Fourier...

Two new anthracene Schiff base triorganotin (IV) compounds trimethylstannyl( E )‐4‐((anthracen‐9‐ylmethylene)amino)benzoate ( 1 ) and triphenylstannyl( 2 were synthesized by mixing trimethylstannyl (or triphenylstannyl) 4‐aminobenzoate 9‐anthraldehyde in anhydrous toluene under refluxing conditions. Elemental analysis, FT‐IR, H‐NMR, 119 Sn NMR ESI‐MS used to determine the composition of compounds. X‐ray diffraction analyses revealed structural details The vitro cytotoxicity assessment these...