Neoklis Apostolopoulos

ORCID: 0000-0001-9749-0795
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About
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Research Areas
  • Allergic Rhinitis and Sensitization
  • Topic Modeling
  • Autoimmune Bullous Skin Diseases
  • Veterinary Oncology Research
  • Mycobacterium research and diagnosis
  • Glycosylation and Glycoproteins Research
  • AI in cancer detection
  • Autoimmune and Inflammatory Disorders
  • Research on Leishmaniasis Studies
  • Toxin Mechanisms and Immunotoxins
  • Oral and gingival health research
  • Wnt/β-catenin signaling in development and cancer
  • Laser Applications in Dentistry and Medicine
  • Healthcare and Venom Research
  • Skin and Cellular Biology Research
  • Nail Diseases and Treatments
  • Biochemical and Structural Characterization
  • Monoclonal and Polyclonal Antibodies Research
  • Dental Radiography and Imaging
  • Poxvirus research and outbreaks
  • Tuberculosis Research and Epidemiology
  • Trypanosoma species research and implications
  • Skin Diseases and Diabetes
  • Dermatology and Skin Diseases
  • Oral and Maxillofacial Pathology

University of Wisconsin–Madison
2022-2025

Louisiana State University
2024

University Hospital Augsburg
2020-2021

Augsburg University
2021

Justus-Liebig-Universität Gießen
2021

Abstract Background Early and accurate diagnosis of otitis externa is crucial for correct management yet can often be challenging. Artificial intelligence (AI) a valuable diagnostic tool in human medicine. Currently, no such available veterinary dermatology/otology. Objectives As proof‐of‐concept, we developed evaluated novel YOLOv5 object detection model identifying healthy ear canals, or masses the canine canal. Animals Digital images canals from dogs with ears, canal were used. Materials...

10.1111/vde.13332 article EN cc-by-nc Veterinary Dermatology 2025-03-03

Atopic dermatitis is one of the most common skin diseases in dogs. Pathogenesis complex and incompletely understood. Skin colonizing bacteria likely play an important role severity this disease. Studying canine microbiota using traditional microbiological methods has many limitations which can be overcome by molecular procedures. The aim study was to describe bacterial ear canals healthy non-allergic allergic German shepherd dogs (GSDs) without acute flare or concurrent infection compare...

10.1371/journal.pone.0250695 article EN cc-by PLoS ONE 2021-05-03

We investigated four cats with similar clinical skin-related signs strongly suggestive of Ehlers-Danlos syndrome (EDS). Cases no. 1 and 4 were unrelated the remaining two cases, 2 3, reportedly siblings. Histopathological changes characterized by severely altered dermal collagen fibers. Transmission electron microscopy in one case demonstrated abnormalities fibril organization structure. The genomes affected siblings sequenced individually compared to 54 feline control genomes. searched for...

10.3390/genes13050797 article EN Genes 2022-04-29

Masticatory myositis (MM) is an inflammatory myopathy reported in dogs and characterized by inflammation of the masticatory muscles (temporalis, masseter, pterygoid muscles). Immunosuppressive therapy current recommended treatment for MM may involve glucocorticoids, cyclosporine, azathioprine, mycophenolate mofetil, leflunomide, or a combination these treatments that are slowly tapered to lowest effective dose. However, side effects from multimodal medical complications associated with...

10.1177/08987564231219925 article EN Journal of Veterinary Dentistry 2024-01-08

A 15‐year‐old male golden retriever who had been receiving prednisolone for orthopaedic problems the past 2 years was presented multifocal symmetrical alopecia, skin nodules and plaques on dorsal aspect of body. Cytology compatible with calcinosis cutis due to suspected iatrogenic hypercortisolism, secondary pyoderma. The Phovia system, a device that emits fluorescent light energy (FLE), used as an adjunct systemic antimicrobial topical (spray shampoo) therapies. Part lesions were covered...

10.1136/vetreccr-2020-001285 article EN cc-by-nc Veterinary Record Case Reports 2020-10-01

Abstract A four‐month‐old female Beagle, with a history of repeated anaphylactic reactions, was managed venom immunotherapy (VIT), based on the results blood allergy test. Because there is lack VIT for dogs, product from human medicine used, which requires serum albumin (HSA) in solvent as stabilizer. HSA has been described to cause sensitization and well other adverse effects dogs. To avoid such effects, water injection used solvent. initiated one‐day ultra‐rush induction scheme, followed...

10.1002/vrc2.13 article EN Veterinary Record Case Reports 2021-01-05

Abstract An 8‐year‐old, female, neutered small Munsterlander presented with multiple ulcerative lesions. Some of these wounds had undermined violaceous borders, indicating lesions pyoderma gangrenosum. Furthermore, a multicentric lymphoma was identified. The administration chemotherapy and both systemic topical immunosuppressive treatments resulted in the complete remission all symptoms for approximately 6 months. However, dog to be euthanased due possible recurrence diseases, characterised...

10.1002/vrc2.970 article EN Veterinary Record Case Reports 2024-08-15

Abstract Background Artificial intelligence (AI) has been used successfully in human dermatology. AI utilises convolutional neural networks (CNN) to accomplish tasks such as image classification, object detection and segmentation, facilitating early diagnosis. Computer vision (CV), a field of AI, shown great results detecting signs skin diseases. Canine paw diseases are common problem general veterinary practice, computer tools could facilitate the monitoring disease processes. Currently, no...

10.1111/vde.13221 article EN cc-by-nc Veterinary Dermatology 2023-12-06

Atypical mycobacterial panniculitis was diagnosed in a cat. Mycobacterium setense identified as causative agent by 16 S rRNA gene sequence analysis. This gram-positive rod-shaped acid-fast bacterium belonging to fortuitum group never reported before diseased animals. Resistance doxycycline and clarithromycin detected. During treatment with pradofloxacin, additional resistance fluoroquinolones developed which due mutation the gyrase gyrA (S90W exchange). Despite of antimicrobial for 33 months...

10.1055/a-1528-1763 article EN Tierärztliche Praxis Ausgabe K Kleintiere / Heimtiere 2021-06-24

In humans, misdiagnoses of monoclonal gammopathy after use therapeutic antibodies has been documented. This triggers concerns for similar in animals treated with antibodies. The aim this study was to evaluate if lokivetmab interferes serum protein electrophoresis and immunofixation dogs.Residual sera from 25 client-owned, healthy blood donor dogs 2 veterinary hospitals Germany were used. residual analysed before being spiked at a concentration 10 µg/ml (corresponding the mean peak...

10.1055/a-1519-3587 article EN Tierärztliche Praxis Ausgabe K Kleintiere / Heimtiere 2021-08-01
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