The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine. Although migraine can be treated using CGRP antagonists that act peripherally, the relevant sites of action remain unknown. To address role both within and outside CNS, we used CGRP-induced light-aversive behavior mice as measure migraine-associated photophobia. Peripheral (intraperitoneal) injection resulted wild-type CD1 similar to aversion seen previously after central (intracerebroventricular) injection....

The neuropeptide calcitonin gene-related peptide (CGRP) plays a critical role in the pathophysiology of migraine. We have focused on CGRP photophobia, which is common migraine symptom. previously used an operant-based assay to show that CGRP-sensitized transgenic ( nestin/hRAMP1 ), but not control, mice exhibited light aversion response intracerebroventricular injection. A key question was whether phenotype due overexpression receptor at endogenous or novel expression sites. reasoned if...

Significance The melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) may contribute to photophobia in migraine. We measured visual discomfort and pupil responses cone melanopsin stimulation—the photoreceptor inputs the ipRGCs—in people with without find that migraine do not differ from those headaches how signals are weighted combined produce discomfort. Instead, is associated amplification of ipRGC for This effect upon limited photophobia, as we did an...

Objective To identify migraineurs and headache-free individuals with an online questionnaire automated analysis algorithm. Methods We created a branching-logic, web-based – the Penn Online Evaluation of Migraine to obtain standardized headache history from previously studied cohort. Responses were analyzed algorithm assign subjects one several categories based on ICHD-3 (beta) criteria. Following pre-registered protocol, primary outcome was sensitivity specificity for assignment...

Background: Reversible cerebral vasoconstriction syndrome (RCVS) is a non-inflammatory vasculopathy. While most patients have good clinical outcomes, RCVS can be associated with severe brain injury from ischemic stroke, subarachnoid, and intracerebral hemorrhage. Purpose: A number of vasoactive medications been implicated in RCVS, including triptans, amphetamines, antidepressants, decongestants. Given the role CGRP modulating vasodilation, possibility inhibitors contributing to has raised....

The primary goal of this study was to develop a parametric model that relates variation in stimulation the trigeminal nerve properties blink response. We measured responses 17 healthy, adult participants air puffs directed at lateral canthus eye five different, log-spaced intensities (3.5-60 PSI). Lid position over time decomposed into amplitude and velocity components. found systematically related log stimulus intensity, with relationship well described by sigmoidal function. parameters fit...

Introduction Calcitonin gene-related peptide (CGRP) plays an important role in cerebral vasodilation, so here we aim to quantify the impact of CGRP monoclonal antibody (mAb) therapy on hemodynamics. Methods In 23 patients with chronic and episodic migraine, hemodynamic monitoring was performed (1) prior (2) 3-months into CGRP-mAb therapy. Transcranial Doppler monitored blood flow velocity (CBFv) middle artery (MCA) posterior (PCA), from which cerebrovascular reactivity (CVR) autoregulation...

To quantify interictal photophobia in migraine with and without aura using reflexive eye closure as an implicit measure of light sensitivity to assess the contribution melanopsin cone signals these responses.Participants were screened meet criteria for 1 3 groups: headache-free (HF) controls, (MO), visual (MA). MO MA participants included if they endorsed ictal photophobia. Exclusion impaired vision, inability collect usable pupillometry, history either head trauma or seizure. Participants...

The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine. Although migraine can be treated using CGRP antagonists that act peripherally, the relevant sites of action remain unknown. To address role both within and outside CNS, we used CGRP-induced light-aversive behavior mice as measure migraine-associated photophobia. Peripheral (intraperitoneal) injection resulted wild-type CD1 similar to aversion seen previously after central (intracerebroventricular) injection....

Abstract Objective To identify migraineurs and headache-free individuals with an online questionnaire automated analysis algorithm. Methods We created a branching-logic, web-based questionnaire—the Penn Online Evaluation of Migraine (POEM)—to obtain standardized headache history from previously studied cohort. Responses were analyzed algorithm to assign subjects one several categories based on ICHD-3 (beta) criteria. Following pre-registered protocol, this result was compared prior...