N. Hildebrand

ORCID: 0000-0001-9769-5889
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About
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Research Areas
  • Nuclear Physics and Applications
  • Nuclear physics research studies
  • Polymer Surface Interaction Studies
  • Nuclear reactor physics and engineering
  • Astronomical and nuclear sciences
  • Molecular spectroscopy and chirality
  • Protein purification and stability
  • Atomic and Molecular Physics
  • Membrane Separation and Gas Transport
  • Radioactive Decay and Measurement Techniques
  • Bone Tissue Engineering Materials
  • Radioactive contamination and transfer
  • Minerals Flotation and Separation Techniques
  • Ion-surface interactions and analysis
  • Plasma Diagnostics and Applications
  • Atomic and Subatomic Physics Research
  • Alkaline Phosphatase Research Studies
  • Electrohydrodynamics and Fluid Dynamics
  • Nanopore and Nanochannel Transport Studies
  • Protein Structure and Dynamics
  • Mechanical and Optical Resonators
  • Electrochemical sensors and biosensors
  • Spectroscopy and Quantum Chemical Studies
  • Force Microscopy Techniques and Applications
  • Algal biology and biofuel production

University of Bremen
2015-2019

Faserinstitut Bremen
2018

Johannes Gutenberg University Mainz
1985-1988

A search for superheavy elements was made in bombardments of $^{248}\mathrm{Cm}$ with $^{48}\mathrm{Ca}$ ions performed at projectile energies close to the interaction barrier order keep excitation energy compound nucleus $Z=116$, $A=296$ as low possible. No evidence nuclei obtained a half-life region from 1 \ensuremath{\mu}s 10 yr production cross section greater than ${10}^{\ensuremath{-}34}$ ${10}^{\ensuremath{-}35}$ ${\mathrm{cm}}^{2}$.

10.1103/physrevlett.54.406 article EN Physical Review Letters 1985-02-04

Yields for isotopes of Rn through Pu have been measured in the reaction $^{48}\mathrm{Ca}$${+}^{248}$Cm at an energy 248--263 MeV (1.04--1.10 times Coulomb barrier). Despite low bombarding energy, high and essentially constant integral yields about 1 to 2 mb elements U were observed. There is evidence that these nuclides are produced with little excitation energy.

10.1103/physrevc.33.1983 article EN Physical Review C 1986-06-01

The adsorption of α-chymotrypsin and hen egg white lysozyme on amorphous silica is studied by molecular dynamics (MD) simulations in comparison with experiments. Protein–surface interaction profiles are computed implicit solvent at the level DLVO theory. These reveal a preferential orientation for chymotrypsin, driven its large dipole moment, α-helical regions pointing toward surface. Instead, less clear orientational preference characterizes adsorption, which approaches surface side-on...

10.1021/acs.jpcc.5b00560 article EN The Journal of Physical Chemistry C 2015-03-12

Adsorption of enzymes on solid surfaces may lead to conformational changes that reduce their catalytic conversion activity and are thus detrimental the efficiency biotechnology or biosensing applications. This work is a joint theoretical experimental endeavor in which we identify quantify chymotrypsin undergoes when contact with surface amorphous silica nanoparticles. For this purpose, use circular dichroism spectroscopy, standard molecular dynamics, advanced-sampling methods. Only...

10.1021/acsbiomaterials.8b00819 article EN ACS Biomaterials Science & Engineering 2018-11-06

In order to understand fundamental interactions at the interface between immobilized enzymes and ceramic supports, authors compare adsorption features of chymotrypsin on SiO2 TiO2 colloidal particles by means a combination experiments molecular dynamics simulations. While dependency amount pH is consistent with trend predicted Derjaguin-Landau-Verwey-Overbeek theory, other effects can only be rationalized if atomic-scale details water-mediated protein–surface are considered. On both...

10.1116/1.4940701 article EN Biointerphases 2016-02-11

Force-distance curves of proteins detaching from oxide surfaces measured by atomic force microscopy are interpreted with atomic-scale models which reveal the significance disulfide and hydrogen bond patterns on protein stability.

10.1039/c8cp03747g article EN Physical Chemistry Chemical Physics 2018-01-01

10.1016/0168-9002(85)90908-8 article EN Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 1985-02-01

Although successful in the structural determination of ordered biomolecules, spectroscopic investigation oligopeptides solution is hindered by their complex and rapidly changing conformational ensemble. The measured circular dichroism (CD) spectrum an oligopeptide ensemble average over all microstates, severely limiting its interpretation, contrast to biomolecules. Spectral deconvolution methods estimate secondary structure contributions are still mostly based on databases larger proteins....

10.1021/acs.jpcb.9b03932 article EN The Journal of Physical Chemistry B 2019-07-10

10.1016/0168-9002(87)90108-2 article EN Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 1987-10-01

Ceramic capillary membranes conditioned for virus filtration via functionalization with n-(3-trimethoxysilylpropyl)diethylenetriamine (TPDA) are analyzed respect to their retention capacity when using feed solutions based on monovalent and divalent salts (NaCl, MgCl2). The log reduction value (LRV) by operating in dead-end mode the model bacteriophage MS2 a diameter of 25 nm an IEP 3.9 is as high 9.6 feeds containing MgCl2. In contrast, lesser LRV 6.4 observed NaCl. TPDA functionalized...

10.1039/c8cp01607k article EN Physical Chemistry Chemical Physics 2018-01-01
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