A5090748622- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Organic and Inorganic Chemical Reactions
- Enzyme Catalysis and Immobilization
- Catalytic Cross-Coupling Reactions
- Glycosylation and Glycoproteins Research
- Catalytic C–H Functionalization Methods
- Microbial Natural Products and Biosynthesis
- Sulfur-Based Synthesis Techniques
Laboratoire COBRA
2017-2022
Centre National de la Recherche Scientifique
2017-2022
Université de Rouen Normandie
2017-2022
Normandie Université
2017-2022
Institut National des Sciences Appliquées Rouen Normandie
2017-2022
A multicomponent Knoevenagel–aza-Michael cyclocondensation (KaMC) reaction starting from Meldrum's acid has been developed with base-sensitive N-Fmoc-hydroxylamine. The takes place under very mild basic conditions, providing a straightforward synthetic route to various unprecedented N-Fmoc-isoxazolidin-5-ones. Subsequent chemoselective reductive cleavage of the N–O bond in presence Zn/AcOH allowed short synthesis corresponding N-Fmoc-β-amino acids.
The deprotonative intramolecular-amination reaction of phenylalanine-derived palladacycles has been investigated to highlight a facile carbonate-assisted N–H activation before the C–N bond formation. A major counterion effect led divergent pathways whereby SPhos-Pd complexes with iodine, triflate, or trifluoroacetate anions were key intermediates afford access (S)-2-indolinecarboxylic acid derivatives.
An expeditious synthesis of taurine derivatives though a key unprecedented organocatalyzed enantioselective sulfa-Michael addition bisulfite onto nitrostyrenes.