A5083449589- Human Health and Disease
- Mitochondrial Function and Pathology
- Pregnancy and preeclampsia studies
- Marine and environmental studies
- Pneumonia and Respiratory Infections
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Neonatal Health and Biochemistry
- Vitamin D Research Studies
- Cytokine Signaling Pathways and Interactions
- Folate and B Vitamins Research
- PARP inhibition in cancer therapy
- Metabolism and Genetic Disorders
- interferon and immune responses
- Diet, Metabolism, and Disease
- Pharmacological Effects of Medicinal Plants
- Natural product bioactivities and synthesis
- Virus-based gene therapy research
- Nosocomial Infections in ICU
- Atherosclerosis and Cardiovascular Diseases
- Natural Products and Biological Research
- Vitamin C and Antioxidants Research
- Tuberculosis Research and Epidemiology
- Antibiotic Use and Resistance
- Immune Cell Function and Interaction
West Kazakhstan Marat Ospanov State Medical University
2012-2025
Kazakhstan Medical University
2023
Data on the prevalence of most inborn errors metabolism are still unavailable in Kazakhstan. The study aims to perform selective screening for hereditary metabolic diseases among patients aged from 1 day 18 years western Kazakhstan using LC-MS/MS method, with establishing reference values content amino acids, acylcarnitines, and succinylacetone blood samples healthy children. Tasks: 1. To assess burden disorders detected by examination children at clinical risk pediatric clinics throughout...
Objective: To assess homocysteine (Hcy) concentration in women with preeclampsia (PE).Methods: Hcy concentrations were detected by ELISA 305 pregnancies.Results: patients PE was 16.07 umol/L at 10-14 weeks as compared to 7.19 normotensive pregnancies (p < 0.0001). Optimal cutoff level for the first trimester of pregnancy >9.55 area under curve 0.859, sensitivity 91.67%, specificity 72.24%.Conclusion: Assessment serum may be used a predictor PE, highest diagnostic utility pregnancy.
Background.Nicotinamide phosphoribosyltransferase (Nampt/visfatin/PBEF) acts both as an enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis pathway well extracellular hormone (eNampt).Among its effects, eNampt exerts potent pro-inflammatory effects.We have recently shown that, rats, stimulates corticosterone secretion by acting through pituitary rather than hypothalamus.Objectives.To investigate mechanism of action on adrenocorticotropic (ACTH) and chemokine (C-C motif) ligand 2...
<b>Introduction:</b> The study of the genetic aspects bone metabolism disorders in children is a theoretical and practical interest for pediatrics, especially according to age ethnic positions. There number gene polymorphisms&nbsp;(primarily vitamin D receptor (VDR) gene) that determine norm pathology tissue formation. Calcium absorption worsens when there no functional VDR active forms D. As result level mineralization decreases. In such lead development osteopenia.<br...
This study investigated a range of gene polymorphisms encoding IL-1, IL-6, IL-10, and TNF-α ‒308 in 100 healthy unrelated Kazakhs using real-time PCR. The findings were compared with published data on other populations. distribution genotypes was consistent the Hardy-Weinberg equilibrium. However, frequency cytokine observed Kazakh population showed similarities differences to neighboring ethnic groups. most noticeable Iranians, Turks, Russians, Chinese IL-10 genotypes. genotype differed...
Aim. To study the effect of oil extracts burdock root and elecampane on lipid profile in an experimental model cholesterolosis. Methods. Experiments were performed 60 white nonlinear rats, weighing 180-300 g. The extract from was administered intragastrically at a dose 2.5 ml/kg, - 1.0 ml/kg during last 30 days background cholesterol diet. After removal animals experiment levels cholesterol, triglycerides, high low density lipoproteins, phospholipids, free fatty acids determined blood serum...
М. Оспанов атындағы Батыс Қазақстан мемлекеттік медицина университеті, Ақтөбе қ
Nuclear explosions, radiation accidents and tests at military training grounds cause technogenic pollution of soil, water, plants, which affect not only the environment, but also have a negative impact on human health. The purpose research was to study environmental status morbidity population territory former test site "Emba-5". Generally accepted methods were used content radionuclides heavy metals in water plant products. A retrospective analysis mortality Mugalzhar district (for period...
Background: There is a category of people with congenial predisposition to alcohol abuse among the total population. The identification such persons by molecular genetic diagnostics and implementation appropriate preventive measures can significantly reduce incidence alcoholism. Objectives: This research aimed study foundations dependence development in Kazakhs based on analysis population frequencies polymorphic variants alcoholism genes. Materials Methods: material for was DNA recovered...