A5057262536- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Drug Transport and Resistance Mechanisms
- Insect Resistance and Genetics
- Neurobiology and Insect Physiology Research
Onderstepoort Veterinary Institute
2015-2022
Onderstepoort Veterinary Academic Hospital
2015-2019
University of Pretoria
2015-2019
Agricultural Research Council of South Africa
2019
Clemson University
2014
ABSTRACT Foot-and-mouth disease (FMD) virus (FMDV) circulates as multiple serotypes and strains in many regions of endemicity. In particular, the three Southern African Territories (SAT) are maintained effectively their wildlife reservoir, buffalo, individuals may harbor SAT for extended periods pharyngeal region. However, exact site mechanism persistence remain unclear. FMD buffaloes offers a unique opportunity to study FMDV persistence, transmission from carrier ruminants has convincingly...
Foot-and-mouth disease virus (FMDV) is a highly contagious of cloven-hoofed animals and recognized as the most important constraint to international trade in animal products. African buffaloes ( Syncerus caffer ) are efficient carriers FMDV, it has been proposed that new variants produced buffalo during prolonged carriage after acute infection, which may spread cause livestock populations. Here, we show despite an accumulation low-frequency sequence over time, there no evidence significant...
Foot-and-mouth disease virus (FMDV) is highly contagious and infects cloven-hoofed domestic livestock leading to foot-and-mouth (FMD). FMD outbreaks have severe economic impact due production losses associated control measures. FMDV found as seven distinct serotypes, but there are numerous subtypes within each serotype, effective vaccines must match the circulating in field. In addition, O Southern African Territories (SAT) relatively more thermolabile their viral capsids readily dissociate...
The effective control of foot-and-mouth disease (FMD) relies strongly on the separation susceptible and infected livestock or persistently wildlife, vaccination, veterinary sanitary measures. Vaccines affording protection against multiple serotypes for longer than six months that are less reliant cold chain during handling urgently needed FMD in endemic regions. Although much effort has been devoted to improving immune responses elicited through use modern adjuvants, their efficacy is...
Abstract Foot-and-mouth disease (FMD) is one of the most important livestock diseases restricting international trade. While African buffalo ( Syncerus caffer ) act as main wildlife reservoir, viral and immune response dynamics during FMD virus acute infection have not been described before in this species. We used experimental needle inoculation contact infections with three Southern Territories serotypes to assess clinical, virological immunological for thirty days post infection. Clinical...
Abstract Foot-and-mouth disease (FMD) is one of the most important livestock diseases restricting international trade. While it clear that African buffalo ( Syncerus caffer ) act as main wildlife reservoir, viral and immune response dynamics during FMD virus acute infection have not been described before in this species. We used experimental needle inoculation contact infections with three Southern Territories serotypes to assess clinical, virological immunological for thirty days post...