A5062689986- Trace Elements in Health
- Alzheimer's disease research and treatments
- Heavy Metal Exposure and Toxicity
- Nerve injury and regeneration
- Drug Transport and Resistance Mechanisms
- Dementia and Cognitive Impairment Research
- Pesticide and Herbicide Environmental Studies
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Pesticide Residue Analysis and Safety
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Biochemical effects in animals
- Lung Cancer Treatments and Mutations
- Aluminum toxicity and tolerance in plants and animals
- Transcranial Magnetic Stimulation Studies
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Chromatography in Natural Products
- Pharmaceutical and Antibiotic Environmental Impacts
- Marine Sponges and Natural Products
- Neurogenesis and neuroplasticity mechanisms
Fatebenefratelli Hospital
2014-2023
Institute of Cognitive Sciences and Technologies
2016-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2013
Centro San Giovanni di Dio Fatebenefratelli
2002-2013
Università Campus Bio-Medico
2008-2013
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2009
Ospedale San Pietro Fatebenefratelli
2008
University of Naples Federico II
1996-2002
Istituto Superiore di Sanità
1993-1995
To assess whether serum copper in Alzheimer disease (AD) correlates with cognitive scores, beta-amyloid, and other CSF markers of neurodegeneration.The authors studied copper, ceruloplasmin, total peroxide, antioxidants levels (TRAP) serum; beta-amyloid plasma; h-tau, P-tau the 28 patients AD 25 healthy controls, relation to clinical status.Serum (p < 0.0001), peroxides = 0.002), a fraction unexplained by ceruloplasmin h-tau 0.001) were increased AD, whereas TRAP 0.03) decreased 0.0001)....
Consistent evidence indicates the involvement of brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson’s (PD). In present study, we compared serum BDNF 624 subjects: 266 patients affected by AD, 28 frontotemporal dementia (FTD), 40 Lewy body (LBD), 91 vascular (VAD), 30 PD, 169 controls. Our results evidenced lower levels FTD, LBD, VAD (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Serum copper not bound to ceruloplasmin ("free") appears slightly elevated in patients with Alzheimer disease (AD). We explored whether a deregulation of the free pool can predict AD clinical worsening.We assessed levels copper, iron, zinc, transferrin, ceruloplasmin, peroxides, total antioxidant capacity, and apolipoprotein E genotype 81 mild or moderate AD, mean age 74.4, SD = 7.4 years, clinically followed up after 1 year. The association among biologic variables under study Mini-Mental...
Objective Meta‐analyses show that nonbound ceruloplasmin (non‐Cp) copper (also known as free or labile copper) in serum is higher patients with Alzheimer disease (AD). It differentiates subjects mild cognitive impairment (MCI) from healthy controls. However, a longitudinal study on an MCI cohort has not yet been performed to assess the accuracy of non‐Cp for prediction conversion AD during long‐term follow‐up. Methods The included 42 converters and 99 stable subjects. We assessed levels...
In patients affected by Alzheimer's disease (AD), serum copper not bound to ceruloplasmin ('free' copper) appears elevated, slightly but significantly enough distinguish AD from healthy elderly subjects. this paper we tested the hypoth
Oxidative status may play a role in chronic inflammation and neurodegeneration which are considered critical etiopathogenetic factors Multiple Sclerosis (MS), both the early phase of disease progressive one. The aim this study is to explore oxidative related iron metabolism peripheral blood stable Relapsing-Remitting MS with low disability. We studied 60 patients (age 37.2 ± 9.06, EDSS median 1.0), 40 healthy controls 40.3 10.86). measured total hydroperoxides (dROMs test) Total Antioxidant...
Background: Growing evidence suggests that the endocannabinoid system is involved in pathogenesis of Alzheimer's disease (AD) and atherosclerosis. Objective: The purpose this study was to investigate activation syste
Meta-analyses demonstrate copper involvement in Alzheimer's disease (AD), and the systemic ceruloplasmin status relation to is an emerging issue. To deepen this matter, we evaluated levels of concentration, activity, specific activity (eCp/iCp), c opper, non-ceruloplasmin iron, transferrin, ceruloplasmin/transferrin ratio, APOE genotype a sample 84 AD patients 58 healthy volunteers. From univariate logistic analyses found that eCp/iCp, copper, were significantly associated with probability...