A5056849981- RNA and protein synthesis mechanisms
- Escherichia coli research studies
- Bacterial Genetics and Biotechnology
- Urinary Tract Infections Management
- Antibiotic Resistance in Bacteria
- Protein Structure and Dynamics
- Cellular transport and secretion
- Advanced Control Systems Optimization
- Genomics and Rare Diseases
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Gut microbiota and health
Quadram Institute
2023
University of East Anglia
2023
University of Birmingham
2020
Biology of Infection
2020
The Edgbaston Hospital
2020
Abstract Background Urinary tract infections (UTIs) are a frequent cause for visits to primary care providers. In alignment globally, uropathogenic Escherichia coli (UPEC) the main aetiological agent UTIs in Norfolk and increasingly difficult treat due multi-drug resistance. Objectives We set out identify which clonal groups resistance genes disseminating community hospitals Norfolk, first study of its kind UPEC this region. Methods collected 199 clinical E. isolates causing hospital from...
The ATPase SecA is an essential component of the bacterial Sec machinery, which transports proteins across cytoplasmic membrane. Most contain a long C-terminal tail (CTT). In
Flux balance analysis (FBA) is a mathematical approach to finding an optimal net flow of mass through metabolic network that follows set instructions defined by the user. This protocol covers principles behind FBA and provides coding examples can be followed using Python3. A basic understanding following aspects linear algebra advantageous: vectors, matrices, transposition, matrix multiplication, decomposition.
ABSTRACT The ATPase SecA is an essential component of the bacterial Sec machinery, which transports proteins across cytoplasmic membrane. Most contain a long C-terminal tail (CTT). In Escherichia coli , CTT contains structurally flexible linker domain and small metal-binding (MBD). MBD coordinates zinc via conserved cysteine-containing motif binds to SecB ribosomes. this study, we screened high-density transposon library for mutants that affect susceptibility E. sodium azide, inhibits...
ABSTRACT Proteins that are translocated across the cytoplasmic membrane by Sec machinery must be in an unfolded conformation order to pass through protein-conducting channel during translocation. Molecular chaperones assist Sec-dependent protein translocation holding substrate proteins cytoplasm until they can delivered membrane-embedded machinery. For example, Escherichia coli , SecB binds a subset of substrates and delivers them interacting with metal-binding domain (MBD) SecA, ATPase...
Synopsis Background Half of all women have experienced a urinary tract infection (UTI) in their lifetime and this remains persistent issue rural counties like Norfolk, UK. In alignment globally, Uropathogenic E. coli (UPEC) are the main etiological agent for UTIs Norfolk increasingly difficult to treat due multi-drug resistance (MDR). Objective We set out identify which clonal groups genes disseminating community hospitals first study its kind UPEC region. Methods collected 217 clinical...