A5055877824- Nanoparticle-Based Drug Delivery
- Mesoporous Materials and Catalysis
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Orthopedic Infections and Treatments
- RNA Interference and Gene Delivery
- Antibiotic Resistance in Bacteria
- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- Supramolecular Self-Assembly in Materials
- Bacterial biofilms and quorum sensing
- Polymer composites and self-healing
- Advanced Polymer Synthesis and Characterization
- Advanced Nanomaterials in Catalysis
- Nanoparticles: synthesis and applications
- Hydrogels: synthesis, properties, applications
- Aerogels and thermal insulation
- Conducting polymers and applications
Madrid Institute for Advanced Studies
2025
Universidad Complutense de Madrid
2017-2023
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2022
Institut Galien Paris-Saclay
2021-2022
Université Paris-Saclay
2021-2022
Centre National de la Recherche Scientifique
2021-2022
Research Institute Hospital 12 de Octubre
2016-2020
Inefficient targeting of muscle stem cells (MuSCs), also called satellite cells, represents a major bottleneck current therapeutic strategies for muscular dystrophies, as it precludes the possibility promoting compensatory regeneration. Here we describe muscle-targeting delivery platform, based on gold nanoparticles, that enables release oligonucleotides into MuSCs. We demonstrate AuNPs conjugation to an aptamer against α7/β1 integrin dimers directs either local or systemic microRNA-206...
In this work, two types of mesoporous carbon particles with different morphology, size, and pore structure have been functionalized a self-immolative polymer sensitive to changes in pH tested as drug nanocarriers. It is shown that their textural properties allow significantly higher loading capacity compared typical silica nanoparticles. vial release experiments model Ru dye at 7.4 5 confirm the pH-responsiveness hybrid systems, showing only small amounts cargo are released physiological pH,...
The several biological barriers that nanoparticles might encounter when administered to a patient constitute the major bottleneck of nanoparticle-mediated tumor drug delivery, preventing their successful translation into clinic and reducing therapeutic profile. In this work, mesoporous silica have been employed as platform engineer versatile nanomedicine able address such barriers, achieving (a) excessive premature release control, (b) accumulation in tissues, (c) selective internalization...
A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented.
Osteomyelitis is an inflammatory process of bone and marrow that may even lead to patient death. Even though this disease mainly caused by Gram-positive organisms, the proportion infections Gram-negative bacteria, such as Escherichia coli, has significantly increased in recent years. In work, mesoporous silica nanoparticles have been employed platform engineer a nanomedicine able eradicate E. coli- related infections. For purpose, loaded with moxifloxacin further functionalized Arabic gum...
Osteomyelitis is a hard-to-treat infection of the bone and marrow that mainly caused by Staphylococcus aureus, with an increasing incidence methicillin-resistant S. aureus (MRSA). Owing to aggressiveness these bacteria in colonizing destroying bone, systemic antibiotic treatments fail eradicate infection. Instead, it normally entails surgery remove dead or infected bone. In this work, we report bone-targeted mesoporous silica nanoparticles for treatment osteomyelitis. The have been...
Injectable therapeutic formulations locally releasing their cargo with tunable kinetics in response to external biochemical/physical cues are gaining interest the scientific community, aim overcome cons of traditional administration routes. In this work, we proposed an alternative solution challenging goal by combining thermo-sensitive hydrogels based on custom-made amphiphilic poly(ether urethane)s (PEUs) and mesoporous silica nanoparticles coated a self-immolative polymer sensitive acid pH...
Correction for ‘Self-immolative polymers as novel pH-responsive gate keepers drug delivery’ by M. Gisbert-Garzaran <italic>et al.</italic>, <italic>RSC Adv.</italic>, 2017, <bold>7</bold>, 132–136.