R. Afifi

ORCID: 0000-0001-9816-9821
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About
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Research Areas
  • Liver Disease Diagnosis and Treatment
  • Hepatitis C virus research
  • Hepatitis B Virus Studies
  • Gastrointestinal disorders and treatments
  • Inflammatory Bowel Disease
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Diagnosis and treatment of tuberculosis
  • Gastrointestinal Tumor Research and Treatment
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Eosinophilic Esophagitis
  • Liver Disease and Transplantation
  • Amoebic Infections and Treatments
  • Autoimmune and Inflammatory Disorders
  • Cancer Genomics and Diagnostics
  • Esophageal and GI Pathology
  • Traumatic Ocular and Foreign Body Injuries
  • Multiple and Secondary Primary Cancers
  • Foreign Body Medical Cases
  • Parasitic infections in humans and animals
  • Potassium and Related Disorders
  • Gastroesophageal reflux and treatments
  • Congenital Anomalies and Fetal Surgery
  • Pancreatitis Pathology and Treatment
  • Restraint-Related Deaths
  • Genetic factors in colorectal cancer

Centre Hospitalier Ibn Sina
2001-2017

Mohammed V University
2015-2017

Carmel Medical Center
2008-2009

Clinique Saint-Joseph
2005

Background Cystic echinococcosis (CE) is a neglected parasitic zoonosis with considerable socioeconomic impact on affected pastoral communities. CE endemic throughout the Mediterranean, including Morocco, where Mid Atlas most prevalent area for both human and animal infection. The highest hospital annual incidence of recorded in provinces Ifrane El Hajeb. However, hospital-based statistics likely underestimate real prevalence infection, as proportion cases never reach medical attention or...

10.1371/journal.pntd.0005384 article EN cc-by PLoS neglected tropical diseases 2017-03-01

To assess the role of major risk factors for hepatocellular carcinoma (HCC) development in western part North Africa.A multicenter case control study was conducted Tunisia, Morocco and Algeria collaboration with Pasteur Institutes these countries. A total 164 patients HCC 250 subjects without hepatic diseases were included. Prevalences HBsAg, anti-hepatitis C virus (HCV) diabetes assessed. HCV HBV genotyping performed anti-HCV HBsAg positive patients.The mean age 62 ± 10 years old a 1.5 M:F...

10.4254/wjh.v3.i1.24 article EN cc-by-nc World Journal of Hepatology 2011-01-01

Background Hepatitis B virus (HBV) is one of the most common human pathogens that cause aggressive hepatitis and advanced liver disease (AdLD), including cirrhosis Hepatocellular Carcinoma. The persistence active HBV replication damage after loss e antigen (HBeAg) has been frequently associated with mutations in pre-core (pre-C) core promoter (CP) regions genome abolish or reduce HBeAg expression. purpose this study was to assess prevalence pre-C CP their impact on subsequent course Morocco....

10.1371/journal.pone.0042891 article EN cc-by PLoS ONE 2012-08-14

Hepatocellular carcinoma (HCC) is characterized by widespread epidemiological and molecular heterogeneity. Previous work showed that in the western part of North Africa, a region low incidence HCC, mutations are scarce for this tumor type. As epigenetic changes considered possible surrogates to human cancers, we decided, thus, characterize DNA methylation HCC from North-African patients. A set 11 loci was investigated series 45 specimens using methylation-specific combined-bisulfite...

10.1186/s12943-015-0340-2 article EN cc-by Molecular Cancer 2015-04-02

Background and objective: Surgery was considered for years the standard treatment all stages of liver hydatid cysts (LHC). Percutaneous has becomes a fast, reliable more efficient method in selected cases. The purpose this study is to evaluate effectiveness percutaneous LHC on basis our department long-term results. Patients Methods: This includes patients who benefited from December 1998 April 2012. Puncture aspiration, injection, re-aspiration (PAIR) were used smaller than 6 cm. Larger...

10.46327/msrjg.1.000000000000077 article EN cc-by-nc-nd Journal of Medical and Surgical Research 2016-12-31

Objective. In the present study, we aimed to investigate epidemiological, clinical, and etiological characteristics of acute upper gastro-intestinal bleeding. Materials Methods. This retrospective study was conducted between January 2003 December 2008. It concerned all cases gastroduodenal bleeding benefited from an urgent endoscopy in our department Morocco. Characteristics patients were evaluated terms age, gender, medical history, presenting symptoms, results rectal clinical examinations,...

10.5402/2011/457946 article EN ISRN Gastroenterology 2011-07-24

Introduction. Hepatitis C is the first major cause for HCC in Morocco. Antiviral treatment reduces risk of developing but few cases HCV-treated patients were reported. We aimed to define this population's features and identify predictive factors HCC. Patients Methods. included all HCV carriers who developed after antiviral from January 2002 April 2010. compare with no population using khi-2 Fisher Exact analysis. Results. 369 HVC-treated considered, 20 The was not significant according...

10.1155/2013/438306 article EN ISRN Hepatology 2012-12-27

Le but de ce travail est d'évaluer l'apport diagnostique la ponction-biopsie échoguidée dans le diagnostic des masses abdominales. Il s'agit d'une étude rétrospective portant sur 523 biopsies échoguidées colligées service médecine C une période six années, allant décembre 2003 à 2009, incluant tous les patients adultes présentant masse abdominale. Deux cent quatre-vingt-trois étaient femmes (54,1 %), et 240 hommes (45,9 %). Les âges extrêmes respectivement 17 84 ans. manifestations cliniques...

10.1007/s12157-010-0206-6 article FR Journal Africain d Hépato-Gastroentérologie 2010-09-06

Introduction: Hepatitis C is the first aetiologic agent for HCC in Morocco. Antiviral treatment reduces risk of developing patients with chronic hepatitis but few cases have been still reported. We aimed to define population high occurrence, confirm protective role SVR and identify predictive factors after SVR. We'll try present suggestions about screening strategies (indications interval) antiviral therapy according level occurrence risk. Patients Methods: included all treated our...

10.46327/msrjg.1.000000000000064 article EN cc-by-nc-nd Journal of Medical and Surgical Research 2016-06-30

L’hépatoblastome est la tumeur hépatique primaire plus commune de l’enfant. Cette extrêmement rare chez l’adulte et son pronostic sombre. Seuls quelques cas ont été rapportés l’adulte. Ainsi, nous présentons dans ce travail le d’un hépatoblastome diagnostiqué une jeune femme 22 ans. Patiente ans sans antécédents, accusant depuis mois des douleurs l’hypochondre droit. L’examen clinique ainsi que bilan étaient particularité. Ni biologie ni les examens morphologiques n’étaient en faveur foie...

10.1007/s12157-012-0392-5 article FR Journal Africain d Hépato-Gastroentérologie 2012-05-05
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