A5022294159- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Retinopathy of Prematurity Studies
- Sleep and Work-Related Fatigue
- Clusterin in disease pathology
- Cerebral Venous Sinus Thrombosis
- Retinal Imaging and Analysis
- Sleep and related disorders
- Urban Transport and Accessibility
- Lipid metabolism and disorders
- Impact of Light on Environment and Health
Shanghai East Hospital
2021-2024
Shanghai Jiao Tong University
2019-2022
Shanghai First People's Hospital
2019-2021
Polypoidal choroidal vasculopathy (PCV) is a major cause of visual loss worldwide, particularly in Asia, and the appropriate understanding structures PCV previously described as polypoidal lesions important for their pathogenesis, diagnosis, prognosis.To report morphologic characteristics association with branching vascular networks (BVNs) eyes using swept-source optical coherence tomographic angiography (SS-OCTA).This cross-sectional observational study included 20 participants recruited...
Background: Although the current role of cytokines and neuroinflammation in glaucoma remains obscure, it represents an expanding field research. The purpose this study was to analyze aqueous humor (AH) patients retinas from ex vivo animal model, aid determining glaucoma. Methods: AH samples were collected 20 during cataract surgeries (controls: n = 10, age 70.3 ± 9.742; glaucoma: age: 66.5 8.073) Shanghai East Hospital, affiliate Tongji University, between September 2018 March 2019 analyzed...
Gasdermin D (GSDMD) is crucial in neuronal pyroptosis. GSDMD-N and GSDMD-C are two subdomains of the protein GSDMD. an executor pyroptosis, has inhibitory effect on pyroptotic cell death. This study evaluated role GSDMD photoreceptor pyroptosis caused by retinal detachment (RD).RD models were established rats, cleavage was detected western blotting. The morphology photoreceptors assessed transmission electron microscopy. Some rats given subretinal injections recombinant adeno-associated...
Background: Bilateral sequential cataract surgery within a short period is becoming more prevalent because of the efficiency and safety modern surgery. It has been reported that first surgical eye might affect contralateral eye. This study investigated cytokines involved in immunopathogenesis pre-existing ocular or systemic conditions, as well inflammatory biomarkers response to topical stimuli, by analyzing cytokine profile aqueous humor (AH) from patients without these morbidities control...
Glaucoma is one of the leading causes worldwide irreversible blindness. Lowering elevated intraocular pressure (IOP) currently only effective approach for controlling progress glaucoma. Angiopoietin-like 7 (ANGPTL7) takes a key part in outflow resistance aqueous humor dysfunctional trabecular meshwork (TM), along with formation cross-linked actin networks (CLANs), to high IOP. In this study, we explored role ANGPTL7 signaling pathway CLAN formation. We detected expression cultured primary TM...
Objective: This study aims to investigate the association of sleep duration with vision impairment (VI) in middle-aged and elderly adults. Methods: cross-sectional used data from baseline survey China Health Retirement Longitudinal Study (CHARLS) 2011-2012, a national adults aged 45 years or older. Weighted multilevel logistic regression models were evaluate between self-reported VI. Results: Of 13,959 respondents, total 4,776 (34.2%) reported The prevalence short (≤6 h/night) long (>8...
Polypoidal choroidal vasculopathy (PCV) is a kind of fundus disease characterized by anomalous branch vascular network and terminal polypoidal dilatation.The pathological basis idiopathic neovascularization similar to age-related macular degeneration (AMD). It controversial that whether PCV AMD the same disease.Optical coherence tomography angiography (OCTA) new, noninvasive imaging technique plays an important role in clinical practice.OCTA not only provides B-scans retina, but also offers...
Abstract Background Sleep disorders may heighten the risk of visual impairment to further impact health outcomes. Little is known regarding association with sleep in China. Our objective was examine disorders. Methods This cross-sectional study used data from 13264 respondents 2011 survey China Health and Retirement Longitudinal Study, a nationally representative adults aged 45 years or older. Visual (VI) duration were examined using self-reported questionnaires. Respondents identified as...