A5030388328- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Neonatal Respiratory Health Research
- Endometriosis Research and Treatment
- Infant Nutrition and Health
- Pregnancy and Medication Impact
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 Clinical Research Studies
- Congenital Anomalies and Fetal Surgery
- Neonatal and Maternal Infections
- Preterm Birth and Chorioamnionitis
- Blood disorders and treatments
- Immune responses and vaccinations
- Enhanced Recovery After Surgery
- Endometrial and Cervical Cancer Treatments
- Adolescent and Pediatric Healthcare
- Esophageal Cancer Research and Treatment
- Uterine Myomas and Treatments
- Breastfeeding Practices and Influences
- Pregnancy and preeclampsia studies
- Esophageal and GI Pathology
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2020-2023
Russian Scientific Center of Surgery
2018
The breastfeeding of infants by mothers who are infected with SARS-CoV-2 has become a dramatic healthcare problem. WHO recommends that women should not abandon breastfeeding; however, there is still the risk contact transmission. Convalescent donor milk may provide defense against aforementioned issue and can eliminate consequences artificial feeding. Therefore, it vital to characterize epitope-specific immunological landscape human from recovered COVID-19. We carried out comprehensive...
One of the causes death patients infected by SARS-CoV-2 is induced respiratory failure caused excessive activation immune system, so-called "cytokine storm", leading to damage lung tissue. In vitro models reproducing various stages disease can be used explore pathogenetic mechanisms and therapeutic approaches treating consequences a cytokine storm. We have developed an in test system for simulating pulmonary epithelium as result development hyperinflammatory reaction based on co-cultivation...
Currently, as the SARS-CoV-2 pandemic evolves, there has been increasingly more attention paid to building natural and vaccine-induced immunity against related disease known COVID-19. Widespread preventive vaccination plays an important role in effectively protecting people from viral infections can reduce national economic costs. Purpose study peripheral blood cell subset composition magnitude of humoral response vaccinated Gam-COVID-Vac subjects. The prospective included 352 patients,...
In the context of COVID-19 pandemic, scientific interest is growing in studying impact proposed vaccination on women’s reproductive health. As known, alterations state immune system and activation an autoimmune response can lead to failure women potential complications subsequent pregnancy. Objective: evaluate effect “Gam-COVID-Vac” status parameters, relationship their changes specific with dynamics level autoantibodies age. The prospective study included 120 who were vaccinated against...
The aim of this prospective randomized clinical study was to investigate the role preoperative carbohydrate admnistration in surgery-induced metabolic, immune and inflammatory reactions after thoracoabdominal operations. At Surgical department I (B.V. Petrovsky National Research Center Surgery), we investigated a modulatory preload upon surgical stress observed major operations (thoracoscopic open esophagectomy, retrosternal colonic esophagoplasty) followed by enhanced recovery protocol....
Aim To investigate the impact of patient immune status on severity COVID-19 Materials and methods The prospective study included 63 employees V I Kulakov NMRC for OG&P Minzdrav Russia with confirmed patients were stratified into three groups based disease severity, including asymptomatic (group 1, n=17), mild 2, n=29), moderate 3, n=17) form On days 3–7 from onset disease, peripheral venous blood samples collected subjects tested serum levels anti-SARS-CoV-2 IgG antibodies profile by ELISA...
Клиническая иммунология
Objective To identify IgG antibodies to SARS-CoV-2 in healthcare professionals of the National Medical Research Center for Obstetrics, Gynecology and Perinatology during quarantine from April June 2020 Materials methods The study included 1589 workers: 1293 ‘green zone’ 926 medical staff of‘red blood serum were determined using SARS-CoV-2-IgG- ELISA kits (National Hematology Center, Russia) RNA was extracted nasopharyngeal swabs kit PROBA-NK(DNA-technology, LLC, virus identified by RT-PCR...
We aimed for assessing effects of immunocytotherapy upon the subpopulations CD4 + CD25 high FoxP3 cellswithnaturalregulatoryactivityandactivatedTh17cellswiththeCD4 RORγt phenotype, as well in vitro production cytokines mitogen-stimulated cells from peripheral blood patients with idiopathic habitual miscarriage (IHM). The study group consisted 33 IHM who became pregnant after a pre-gestational alloimmunization. In 27 patients, pregnancy was prolonged to full term and ended birth viable...
The aim of this work was to characterize phenotypically peripheral blood T- and NK lymphocytes expressing an early marker activation, CD69, assess the significance CD69 expression for predicting pregnancy outcome in women with idiopathic reccurent loss (IRP) before after immunocytotherapy (ICT). study group consisted 36 patients IRP who became pregnant pre-gestational allimmunization, 30 prolonged full term ended birth a viable baby, 6 — it terminated 12 weeks gestation. In control group, 15...
The aim of our study was to evaluate the macrophage inhibitory factor (MIF) content in peripheral blood serum, as well MIF production by mitogen-stimulated cells from whole during pregnancy women with idiopathic recurrent miscarriage who received immunocytotherapy both prior and first trimester pregnancy. involved 51 20 40 years old: 10 fertile healthy females beyond pregnancy, 23 (IRM), 18 a physiological course at different stages gestation (12, trimester; 12, second; 9, third trimester)....
The relationship between the incidence of COVID-19 in pregnant women who have had a coronavirus infection at different gestational ages and health status paired neonates is great interest. However, no sufficient convincing data fully reflecting features subsequent neonatal period, state immune system this category children, affecting characteristics postnatal period been accumulated. Based on this, it underlies relevance current study aimed investigating parameters clinical immunological...