A5056861300- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Ion Channels and Receptors
- Echinoderm biology and ecology
- Pneumothorax, Barotrauma, Emphysema
- Biomedical Research and Pathophysiology
- Biochemical Analysis and Sensing Techniques
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Gastric Cancer Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Regulation of Appetite and Obesity
- Abdominal Surgery and Complications
- Dermatological and Skeletal Disorders
- Pharmacological Effects and Toxicity Studies
- Genetic factors in colorectal cancer
- Chromatin Remodeling and Cancer
- Diabetes Management and Research
- Seaweed-derived Bioactive Compounds
- Gastrointestinal Tumor Research and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Pancreatic function and diabetes
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
Gunma University Hospital
2019-2022
Gunma University
2008-2009
Kanazawa University
1996
Abstract Because the significance of P-glycoprotein in in-vivo secretion β-blockers intestinal epithelial cells is unclear, secretory mechanism for and other drugs has been evaluated. Uptake acebutolol, celiprolol, nadolol timolol, antiarrhythmic agent, quinidine by multidrug-resistant leukaemic cell line variant K562/ADM was significantly lower than that drug-sensitive K562 cells, suggesting these are transported out cells. The reduced uptake acebutolol drug-resistant reversed treating with...
Calcium-permeable cation channel TRPV2 is expressed in pancreatic beta-cells. We investigated regulation and function of beta-cells.Translocation was assessed MIN6 cells cultured mouse beta-cells by transfecting fused to green fluorescent protein or containing c-Myc tag the extracellular domain. Calcium entry monitoring fura-2 fluorescence.In cells, observed mainly cytoplasm an unstimulated condition. Addition exogenous insulin induced translocation insertion plasma membrane. Consistent with...
The aim of this study is to assess whether fucoidan modulates the expression chemokine ligand 12 (CXCL12)/chemokine receptor 4 (CXCR4) and exerts antitumor activity toward Huh7 hepatoma cells. According 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, inhibited growth cells HepG2 in a dose-dependent manner, with 50% inhibition cell (IC50) 2.0 4.0 mg/ml, respectively. alpha-fetoprotein levels medium collected from fucoidan-treated were significantly decreased but not...
The present study was conducted to establish a method induce differentiation of bone marrow (MB)-derived mesenchymal cells into insulin-producing cells. When mouse BM-derived were cultured for 60 days in medium containing 10% fetal calf serum and 25 mM glucose, they expressed insulin. Addition activin A betacellulin (BTC) accelerated differentiation, immunoreactive insulin detected 14 after the treatment. Insulin-containing secretory granules observed differentiated by electron microscopy....
The patient was an 86-year-old man who admitted with obstructive jaundice. Computed tomography revealed a tumor in the hilar choledochus peripheral hepatic duct dilatation. Endoscopic cholangiography (ERC) demonstrated defect choledochus. Brushing cytology during ERC showed Orange-G-philic keratinized atypical cells, which led to diagnosis of squamous cell carcinoma. Chemotherapy tegafur-gimeracil-oteracil potassium ineffective and discontinued due adverse effects. died 5 months after...
Contrast-enhanced computed tomography (CT) scan (portal phase) at the onset. Emphysema is detected in ileal wall (b, c: Arrows) and free air abdominal cavity (a: Arrowhead). CT imaging settings: (a-c) window level (WL) 60 width (WW) 300. (d-f) WL 0 WW 433. By changing settings, intestinal emphysema can be more easily identified.