A5022187302- Prenatal Substance Exposure Effects
- Opioid Use Disorder Treatment
- Renal function and acid-base balance
- Clinical Laboratory Practices and Quality Control
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Neonatal Health and Biochemistry
- Cancer Cells and Metastasis
- Alcohol Consumption and Health Effects
- Erythropoietin and Anemia Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Psychedelics and Drug Studies
- Drug-Induced Hepatotoxicity and Protection
- Retinoids in leukemia and cellular processes
- Bioactive natural compounds
- Parathyroid Disorders and Treatments
- NF-κB Signaling Pathways
- Neonatal and fetal brain pathology
- Chronic Lymphocytic Leukemia Research
- Neurotransmitter Receptor Influence on Behavior
- Phagocytosis and Immune Regulation
- Inflammatory mediators and NSAID effects
- Alkaline Phosphatase Research Studies
- Pharmacological Effects and Toxicity Studies
University of Utah
2021-2025
ARUP Laboratories (United States)
2021-2025
ARUP Institute for Clinical and Experimental Pathology
2022-2025
University of Alberta
2016-2021
University of Manitoba
2018
Universidad Nacional Autónoma de México
2018
Women and Children’s Health Research Institute
2018
Abstract Background – Alcohol is the most abused substance in Western society, resulting major economic losses and negative health consequences. Therefore, there a need for selective robust detection method alcohol consumption various clinical forensic settings. This study aimed to validate mass spectrometry quantifying phosphatidylethanol (PEth) perform retrospective data analysis from patient population of national reference laboratory. Methods: Quantification whole blood was accomplished...
Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It one of the most promising natural molecules in prevention and treatment chronic diseases autoimmune disorders. One key limitations clinical use resveratrol its extensive metabolic processing to glucuronides sulfates. has been estimated around 75% this excreted via feces urine. To possibly alleviate improve bioavailability, we have added segments...
Apoptosis is fundamental to normal animal development and the target for many anticancer therapies. Recent studies have explored consequences of "failed apoptosis" where apoptotic program initiated but does not go completion cause cell death. Nevertheless, this failed apoptosis induces DNA double-strand breaks generating mutations that facilitate tumorigenesis. Whether relevant clinical disease unknown. BCL-2 interacting killer (BIK) a stress-induced BH3-only protein stimulates in response...
Receptor-interacting protein kinase 2 (RIP2 or RICK, herein referred to as RIPK2) is linked the pathogen pathway that activates nuclear factor <i>κ</i>-light-chain-enhancer of activated B cells (NF<i>κ</i>B) and autophagic activation. Using molecular modeling (docking) chemoinformatics analyses, we used RIPK2/ponatinib crystal structure searched in chemical databases for small molecules exerting binding interactions similar those exerted by ponatinib. The identified RIPK2 inhibitors potently...
// Vrajesh Pandya 1 , Darryl Glubrecht 2 Larissa Vos John Hanson Sambasivarao Damaraju 3 Mackey Judith Hugh Ing Swie Goping 1, Department of Biochemistry, University Alberta, Edmonton, Alberta T6G 2H7, Canada Oncology, Laboratory Medicine and Pathology, Correspondence to: Goping, e-mail: igoping@ualberta.ca Keywords: breast cancer, BH3-only proteins, Bcl-2 interacting killer, BiK, autophagy Received: March 02, 2016     Accepted: April 10, Published: 22, 2016 ABSTRACT...
Abstract Maternal drug use during pregnancy is a significant concern. Drug-exposed newborns are often born premature and may suffer from birth defects, neonatal abstinence syndrome cognitive developmental delays. Because of this, testing specimens carried out to assess fetal exposure pregnancy. Umbilical cord tissue (UC) meconium commonly used for this purpose. However, comprehensive studies comparing positivity rates concentration in the two specimen types lacking. To end, 4,036 paired UC...
Abstract Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis. In Bad 3SA knock-in mice, where cannot undergo phosphorylation at 3 key serine residues, pubertal development is delayed due to aberrant tubulogenesis ductal epithelium. Proteomic and RPPA analyses that regulates focal adhesions mRNA translation repressor, 4E-BP1. These results suggest...
Maternal drug use during pregnancy has significant health and socio-legal implications. The Substance Abuse Mental Health Services Administration publishes self-reported rates of pregnancy; however, comprehensive long-term laboratory data on neonatal exposure are lacking. Over 175,000 meconium specimens originating from 46 US states were analyzed at ARUP Laboratories between the years 2015 2020. A retrospective investigation positivity rates, multidrug detection median concentrations was...
Azim, Aniqa; Hu, Boyu; Gilligan, Sarah; Sarwal, Amara; Hartsell, Sydney; Pandya, Vrajesh; Raphael, Kalani L. Author Information
Many low-complexity urine drug screen (UDS) devices are approved by the Food and Drug Administration as waived under Clinical Laboratory Improvement Amendments (CLIA) criteria. Labeling instructs patients to urinate directly into device also states that positive results should be confirmed. However, itself may pose a risk of adsorption and/or specimen contamination could affect in confirmatory assays if specimens reused. Collecting separate container before performing UDS would reclassify...
Abstract Substance abuse during pregnancy has significant short- and long-term health, social, legal implications. Hence, prompt determination of a neonate’s drug exposure status can aid the healthcare team in making treatment choices. Umbilical cord tissue (UC) meconium are two commonly used specimens to detect fetal exposure. However, current evidence on sensitivity one specimen over other is both limited conflicting. By utilizing large cohort (n=4036) paired UC samples originating from 13...