A5057676686- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Sirtuins and Resveratrol in Medicine
- Medicinal Plants and Neuroprotection
- Vitamin D Research Studies
- Ferroptosis and cancer prognosis
- Collagen: Extraction and Characterization
- Hippo pathway signaling and YAP/TAZ
- Menstrual Health and Disorders
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Essential Oils and Antimicrobial Activity
- Cytokine Signaling Pathways and Interactions
- Sodium Intake and Health
- Phagocytosis and Immune Regulation
- Curcumin's Biomedical Applications
- Tea Polyphenols and Effects
- Consumer Attitudes and Food Labeling
- Milk Quality and Mastitis in Dairy Cows
- Protein Degradation and Inhibitors
- Listeria monocytogenes in Food Safety
- Genomics, phytochemicals, and oxidative stress
Lebanese International University
2019-2025
Business in the Community
2025
University of Alberta
2014-2024
University of Manitoba
2018
Universidad Nacional Autónoma de México
2018
Women and Children’s Health Research Institute
2018
American University of Beirut
2012
Overcoming the limited bioavailability and extensive metabolism of effective in vitro drugs remains a challenge that limits translation promising into clinical trials. Resveratrol, despite its well-reported therapeutic benefits, is not metabolically stable thus has been utilized as an drug. This because it needs to be consumed large amounts overcome burdens conversion less metabolites. Herein, we summarize more relevant approaches modify resveratrol, aiming increase biological efficacy. We...
Modulator of apoptosis 1 (MOAP-1) is a BH3-like protein that plays key roles in cell death or apoptosis. It an integral partner to the tumor suppressor protein, Ras association domain family 1A (RASSF1A), and functions activate Bcl-2 pro-apoptotic Bax. Although RASSF1A now considered bona fide role MOAP-1 as has yet be determined. In this study, we present several lines evidence from cancer databases, immunoblotting cells, proliferation, xenograft assays well DNA microarray analysis...
Persistent inflammation can trigger altered epigenetic, inflammatory, and bioenergetic states. Inflammatory bowel disease (IBD) is an idiopathic characterized by chronic of the gastrointestinal tract, with evidence subsequent metabolic syndrome disorder. Studies have demonstrated that as many 42% patients ulcerative colitis (UC) who are found to high-grade dysplasia, either already had colorectal cancer (CRC) or develop it within a short time. The presence low-grade dysplasia also predictive...
Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It one of the most promising natural molecules in prevention and treatment chronic diseases autoimmune disorders. One key limitations clinical use resveratrol its extensive metabolic processing to glucuronides sulfates. has been estimated around 75% this excreted via feces urine. To possibly alleviate improve bioavailability, we have added segments...
Background: Olea europaea L, known as olive, is an ancient tree that has been part of traditional and modern therapies. Table olives are produced by curing then fermenting the olive drupe, a process involves debittering fruit eliminating oleuropein, bitter phenolic compound characteristic Oleaceae family. The bitterness important method used with food products to increase quality health benefits several edibles. differs between Spanish, Californian, Greek styles, resulting in different...
Receptor-interacting protein kinase 2 (RIP2 or RICK, herein referred to as RIPK2) is linked the pathogen pathway that activates nuclear factor <i>κ</i>-light-chain-enhancer of activated B cells (NF<i>κ</i>B) and autophagic activation. Using molecular modeling (docking) chemoinformatics analyses, we used RIPK2/ponatinib crystal structure searched in chemical databases for small molecules exerting binding interactions similar those exerted by ponatinib. The identified RIPK2 inhibitors potently...
• Vitamin D performs vital homeostatic and systematic functions in the human body. Skin production is affected by factors such as age, season, latitude, sun exposure. Pandemic deficiency a metabolic abnormality caused complex interplay of factors. Despite regular sunny weather, one third MENA region population vitamin deficient. D3 fortified breads have shown their efficacy increasing serum 25-hydroxy-Vitamin D.
Epigenetic silencing of RASSF1A is frequently observed in numerous cancers and has been previously reported. The promoter region predicted to have 75 CpG sites, very few studies demonstrate how the methylation these sites affects expression. In addition, expression relationship between its downstream target, modulator apoptosis 1 (MOAP-1), poorly understood. this study, we explored mRNA RASSF1A, MOAP-1 well-characterized splice variant RASSF1, RASSF1C, cancer cell lines primary tumors. We...
Hygienic measures practiced at home are highly related to the occurrence of food-borne diseases during food production, storage, and handling. Contaminated remains a major cause several diarrheal diseases, hospitalizations, spikes in medical expenses. In our current study, we aimed assess knowledge safety hygiene practices among Lebanese population. A cross-sectional study was conducted through an online questionnaire including two sections. The first section included socio-demographic...
The use of monoclonal antibodies represents an important and efficient diagnostic therapeutic tool in disease management modern science but remains limited by several factors including the uneven distribution diseased tissues as well undesired activation side immune reactions. Major scientific advancements Recombinant DNA Technology, Hybridoma Polymerase Chain Reaction have considerably impacted providing technical effective solutions to overcome shortcomings encountered with conventional...
Due to their robust antioxidant properties, phenolic acids and analogs are extensively studied for ability activate cellular pathways, including nuclear factor (erythroid-derived-2)-like 2 (Nrf2)-antioxidant response element (ARE) pathway. Caffeic, ferulic, gallic acid well-studied members of acids. Constant efforts made improve the pharmacological effects bioavailability by synthesizing chemical derivatives. This study determines how modifications structure these affect cytoprotective...