A5036977906- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Cellular Mechanics and Interactions
- Head and Neck Cancer Studies
- Data Management and Algorithms
- Cell Image Analysis Techniques
- Metabolomics and Mass Spectrometry Studies
- Natural Language Processing Techniques
- 3D Printing in Biomedical Research
- Cancer survivorship and care
- Web Data Mining and Analysis
- Metabolism and Genetic Disorders
- Global Public Health Policies and Epidemiology
- Renal function and acid-base balance
- Seismology and Earthquake Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Rural Development and Agriculture
- Seismic Imaging and Inversion Techniques
- Palliative Care and End-of-Life Issues
- Lipoproteins and Cardiovascular Health
- Cancer Cells and Metastasis
- Geography and Environmental Studies
- Blood properties and coagulation
- Mathematical Biology Tumor Growth
- Microfluidic and Bio-sensing Technologies
University of Oslo
2021-2024
Universidade Estadual de Campinas (UNICAMP)
2024
University of Coimbra
2018-2020
Angiogenesis - the growth of new blood vessels from a pre-existing vasculature is key in both physiological processes and on several pathological scenarios such as cancer progression or diabetic retinopathy. For vascular networks to be functional, it required that growing sprouts merge either with an existing functional mature vessel another sprout. This process called anastomosis. We present systematic 2D 3D computational study tissue address capability angiogenic factor gradients drive...
Abstract Motivation Trajectories, which are sequentially measured quantities that form a path, an important presence in many different fields, from hadronic beams physics to electrocardiograms medicine. Trajectory analysis requires the quantification and classification of curves, either by using statistical descriptors or physics-based features. To date, no extensive user-friendly package for trajectory has been readily available, despite its importance potential application across various...
Abstract Germline mutations of E-cadherin cause Hereditary Diffuse Gastric Cancer (HDGC), a highly invasive cancer syndrome characterised by the occurrence diffuse-type gastric carcinoma and lobular breast cancer. In this disease, E-cadherin-defective cells are detected invading adjacent stroma since very early stages. Although loss is well established as triggering event, other determinants process persist largely unknown. Herein, we develop an experimental strategy that comprises in vitro...
One of the most fundamental abilities required for sustainability complex life forms is active cell migration, since it essential in diverse processes from morphogenesis to leukocyte chemotaxis immune response. The movement a result intricate mechanisms, that involve coordination between mechanical forces, biochemical regulatory pathways and environmental cues. In particular, epithelial cancer cells have employ strategies order migrate through tissue's basement membrane infiltrate...
Alterations in mitochondrial dynamics, including their intracellular trafficking, are common early manifestations of neuronal degeneration. However, current methodologies used to study trafficking events rely on parameters that primarily altered later stages neurodegeneration. Our objective was establish a reliable applied statistical analysis detect alterations trafficking. We propose novel quantitative mitochondria trajectories based innovative movement descriptors, straightness,...
Patients surviving head and neck cancer (HNC) suffer from high physical, psychological, socioeconomic burdens. Achieving cancer-free survival with an optimal quality of life (QoL) is the primary goal for HNC patient management. So, maintaining lifelong surveillance critical. An ambitious would be to carry this out through advanced analysis environmental, emotional, behavioral data unobtrusively collected mobile devices. The aim clinical trial reduce, non-invasive tools (i.e., patients'...
Este artigo discute os impactos do rompimento da Barragem de Fundão (RBF), ocorrido em 2015, na oferta escolar destinada às populações campesinas município Rio Doce, Minas Gerais. O RBF contaminou o solo e as águas um percurso 600 km, comprometeu a produção reprodução vida região atingida afetou diretamente povos campesinos. A pesquisa busca responder: como desafia escola relação à formação dos estudantes residentes no campo? Para isso, foram realizadas consultas bancos dados oficiais sobre...
Abstract Background Conditional outcomes are defined only under specific circumstances. For example, future quality of life can be ascertained when subjects alive. In prognostic models involving conditional outcomes, a choice must made on the precise target prediction: one could life, given that individual is still alive (conditional) or jointly with event being (unconditional).We aim to (1) introduce probabilistic framework for and (2) apply this develop model 3 years after diagnosis in...
Background: The Big Data for Quality of Life (BD4QoL) study investigates quality life (QoL) in head and neck cancer (HNC) survivors, focusing on survivorship characterizing survivor demographics. Methods: We screened data from 5 studies across Europe (N=7276) included patients with a diagnosis squamous cell carcinoma (oral cavity, hypopharynx, larynx, oropharynx, nasal cavity paranasal sinuses), treated curative intent, alive after treatment, TNM 7th ed. stages I, II, III, IVa IVb,...
Abstract One of the most fundamental abilities required for sustainability complex life forms is active cell migration, since it essential in diverse processes from morphogenesis to leukocyte chemotaxis immune response. The movement a result intricate mechanisms, that involve coordination between mechanical forces, biochemical regulatory pathways and environmental cues. In particular, epithelial cancer cells have employ strategies order migrate through tissue’s basement membrane infiltrate...
Trajectories, sequentially measured quantities that form a path, are an important presence in many different fields, from hadronic beams physics to electrocardiograms medicine. Trajectory anal-ysis requires the quantification and classification of curves either using statistical descriptors or physics-based features. To date, there is no extensive user-friendly package for trajectory available, despite its importance potential application across domains. We developed free open-source python...
Abstract Alterations in mitochondrial dynamics, including their trafficking, can present early manifestation of neuronal degeneration. However, current methodologies used to study trafficking events rely on parameters that are mostly altered later stages neurodegeneration. Our objective was establish a reliable computational methodology detect alterations trafficking. We propose novel quantitative analysis mitochondria trajectories based innovative movement descriptors, straightness,...
Abstract Alterations in mitochondrial dynamics, including their intracellular trafficking, are common early manifestations of neuronal degeneration. However, current methodologies used to study trafficking events rely on parameters that mostly altered later stages neurodegeneration. Our objective was establish a reliable computational methodology detect alterations trafficking. We propose novel quantitative analysis mitochondria trajectories based innovative movement descriptors,...