A5010978051- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Anodic Oxide Films and Nanostructures
- Body Contouring and Surgery
- Immunotherapy and Immune Responses
- Skin Protection and Aging
- Acute Lymphoblastic Leukemia research
- Angiogenesis and VEGF in Cancer
- Marine Sponges and Natural Products
- Adenosine and Purinergic Signaling
- Bioactive Compounds and Antitumor Agents
- Psoriasis: Treatment and Pathogenesis
- PI3K/AKT/mTOR signaling in cancer
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Calcium signaling and nucleotide metabolism
- Laser Applications in Dentistry and Medicine
Ospedale Policlinico San Martino
2016-2018
Universidad de Oviedo
2010-2017
Instituto de Investigación Sanitaria del Principado de Asturias
2010-2016
Epithelial-mesenchymal transition (EMT) is a morphogenetic process characterized by the acquisition of mesenchymal properties linked with an invasive phenotype and metastasis tumor cells. NK group 2, member D (NKG2D) cell-activating receptor crucially involved in cancer immunosurveillance. In this study, we show that induction EMT TGF-β stimulation human keratinocytes, glycogen synthase kinase-3β inhibition several epithelial cell lines, Snail1 overexpression colorectal cells strongly...
The prognostic value of the number T cells and NK at diagnosis in CLL was analyzed a cohort 256 patients with diagnosed between 1997 2007. Patients leukemia showed elevated cell populations CD4/CD8 ratio inverted 39.7% cases. Prognostic significance lymphocytes as relative to size malignant monoclonal B-cell pool (T/NK cells:Malignant B-cells ratio). higher CD4 (p = 0.03), CD8 0.02), 0.01) early Rai stage disease. multivariate Cox analysis identified (hazard (HR) 1.464; p 0.006) (HR 0.091; <...
The immune system may mediate anti-tumor responses in chronic lymphocytic leukemia (CLL) which affect disease progression and survival. In this study, we analyzed the characteristics of 99 consecutive previously diagnosed CLL patients 50 healthy controls. distribution lymphocyte subsets at diagnosis was retrospectively analyzed. Compared with controls, showed an expansion NK CD8 T cells diagnosis. relative number associated time to treatment, suggesting that modify progression. again when...
Tumor cell plasticity is a major obstacle for the cure of malignancies as it makes tumor cells highly adaptable to microenvironmental changes, enables their phenotype switching among different forms, and favors generation prometastatic subsets. Phenotype toward more aggressive forms involves functional, phenotypic, morphologic which are often related process known epithelial-mesenchymal transition (EMT). In this study, we report natural killer (NK) may increase malignancy melanoma by...
Lenalidomide is an immunomodulatory drug with therapeutic activity in chronic lymphocytic leukemia (CLL). However, it has pleiotropic effects, and the mechanism of action responsible for its not been well defined yet. Herein, we show that lenalidomide treatment does have effect on proliferation cells, but increases B cells from healthy donors. did exert a direct apoptosis obtained CLL patients, although indirectly induced their through activation nonmalignant immune cells. Thus, markedly...
ABSTRACT Background Aging associated with the passage of time causes alterations in subcutaneous tissues and overall appearance skin that generate aesthetic unconformities people. Within wide range available techniques on market, radiofrequency (RF) diathermy has emerged as one most used non‐invasive methods to combat them. Objective This clinical trial aims determine quantify effectiveness safety high‐frequency RF‐based device Symmed (Termosalud Inc., Gijón, Spain) cellulite improvement...
Due to the variety and complexity of microorganisms, mechanisms needed for pathogen recognition are diverse. Innate immune is mainly based on a series germ-line encoded receptors that have been selected by evolution recognize nonself molecules present in microorganisms. immunity also recognizes changes our cells caused infection, such as lack or induction self molecules. Adaptative somatically generates large repertories which collectively any antigen. These randomly generated, adaptative...
Formation of polyploid or aneuploid cells is a pathological hallmark malignant tumors. Cell cycle checkpoint mechanisms play crucial role in ensuring genomic integrity during mitosis, avoiding the generation cells. Additionally, cancer cell DNA ploidy subjected to extrinsic controls operated by activation adaptive immune responses mediated T NK exert central innate anticancer immunity; however, involved recognition tumor have not been fully elucidated. Herein, we report that drug-induced...
Abstract Background Excess body adiposity and skin irregularities represent a major problem in today's society. Currently, radiofrequency‐based devices constitute an increasingly popular medical‐aesthetic application powerful non‐invasive method to combat this problem. Objective This study aims determine the efficacy safety of high‐frequency device Zionic™ (Termosalud, Inc., Gijón, Spain) reducing contouring improving appearance abdomen/flanks or thighs. Materials Methods Thirty nine...
Chronic lymphocytic leukemia (CLL) is associated with a profound dysregulation of the immune system. Loss T cell function frequently caused in cancer by sustained signaling inhibitory receptors. Here, we analyzed role novel receptor Ig-like transcript 2 (ILT2) pathogenesis CLL. We observed that ILT2 expression was markedly reduced on leukemic cells, whereas it increased CD8 and CD4 cells from CLL patients, particularly those patients harboring chromosome 11q deletion, which includes ATM...
Demycarosyl-3D-ß-D-digitoxosyl-mithramycin SK (DIG-MSK) is a recently isolated analogue of mithramycin A (MTA) that showed differences with MTA in the DNA binding strength and selectivity. These correlated better therapeutic index less toxicity animal studies. Herein, we show DIG-MSK displays potent anti-tumor activity against different types cancer cell lines, ovarian tumor cells being particularly sensitive to this drug. Of relevance, exerts low on fibroblasts peripheral blood mononuclear...
The plasma membrane receptor natural killer group 2 member D (NKG2D) underpins a major mechanism whereby (NK) and T cells recognize malignant cells. We have recently demonstrated that the epithelial-to-mesenchymal transition, one of first steps metastatic dissemination, is under control an immunological checkpoint relies on NKG2D-mediated immune responses.
<div>Abstract<p>Tumor cell plasticity is a major obstacle for the cure of malignancies as it makes tumor cells highly adaptable to microenvironmental changes, enables their phenotype switching among different forms, and favors generation prometastatic subsets. Phenotype toward more aggressive forms involves functional, phenotypic, morphologic which are often related process known epithelial–mesenchymal transition (EMT). In this study, we report natural killer (NK) may increase...
<p>Table S2</p>
<p>Table S1</p>
<p>Fig S1-S3: Effect of NK cells on melanoma cell lines. Fig S4: Outline transwell experiments. S5: Effects blocking mAbs NK-induced EMT. S6-S7: effects EMT NK-receptor ligand expression. S8: susceptibility to drugs or g-radiation. S9: Supplemental proteomic data. S10,12: IHC. S11: autophagy. S13: two epithelial lines</p>