Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome often misdiagnosed due to its rarity and overlapping symptoms with sepsis or organ dysfunction. This case report describes 52-year-old male who developed dengue-induced HLH after traveling Barbados, presenting multi-organ failure laboratory abnormalities, including hyperferritinaemia elevated IL-2R. Diagnosed via bone marrow biopsy, he was treated corticosteroids the IL-1R antagonist anakinra, leading...

Since the beginning of COVID-19 pandemic, there have been reports neuropsychiatric symptoms following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most notably mania and psychosis. However, despite widely reported incidence psychosis SARS-CoV-2, a causal link between virus these has not established. A myriad confounding factors such as underlying psychiatric disorders, personal family histories, substance use, treatment steroids all ability to obscure...

Priapism is defined as an erection that lasts longer than four hours, unrelated to sexual interest or stimulation, and unrelieved by orgasm. The ischemic subtype a urologic emergency often caused medication side effects, most notably selective serotonin reuptake inhibitors trazodone. We present the case of priapism thought be recent initiation gabapentin.

Mucosal melanomas represent about 1% of all melanoma cases. Primary malignant the esophagus (PMME) is a rare and deadly condition, with only 339 cases reported in literature. Esophageal usually presents progressively worsening dysphagia, patients often present late disease course. can be treated surgical resection, chemotherapy, targeted therapy, or immunotherapy depending on stage tumor mutations. However, due to rarity disease, no trials have been performed deliver gold standard treatment....

Cancer, hypertension, and kidney disease are closely interrelated. Knowledge of the potential hypertensive nephrotoxic effects antineoplastic medications is critical to minimizing interruptions in cancer treatment.

Acute pancreatitis is defined as inflammation of the pancreas and most commonly caused by gallstones alcohol use. Less commonly, acute can be drug induced from medications that are divided into 5 subgroups (classes Ia-V). The determined based on cases reported, reaction with rechallenge a consistent period latency. We describe case 34-year-old female who overdosed losartan pills in suicide attempt but developed symptoms drug-induced nearly week later without gallstones, involvement, or other...

Infective endocarditis (IE) is a serious condition associated with high morbidity and mortality rates. The risk factors for IE include underlying heart disease, intravenous drug use, cardiac surgery, interventional procedures. Enterococci are common cause of IE, vancomycin-resistant enterococci (VRE) infections becoming increasingly prevalent. In this report, we present the case an 88-year-old female patient multiple comorbidities who developed VRE splenic infarction embolic stroke. was...

Penetrating injury can cause pseudoaneurysm which then affect nerve compression. Although rare, penetrating injuries leading to ulnar artery (UAP) are implicated slightly more frequently than other upper extremity arterial segments. Manual compression, thrombin injections, and surgical reconstruction typically chosen effect repair. Conversely, peripheral stent-graft implantation has rarely been reported as an option exclude pseudoaneurysm. We describe a case of 25-year-old male who was...

Checkpoint inhibitors have gained increased traction in recent years as they improved prognosis various malignancies. Pembrolizumab, an anti-programmed cell death protein (PD-1) monoclonal antibody, has become a first-line chemotherapeutic agent for stage II non–small lung cancer since 2019. Although much more common with nivolumab, several immune-related adverse effects, particularly endocrinopathies, been linked pembrolizumab. We describe case of 59-year-old man history unspecified who...

Adult-onset Still's disease is a rare, autoinflammatory characterized by spiking fevers, arthritis, salmon-colored skin rash, and leukocytosis. It has been compared to systemic juvenile idiopathic arthritis because of its similar features but much rarer than pediatric counterpart. usually treated with corticosteroids disease-modifying anti-rheumatic drugs. However, those refractory are candidates for one many biological therapies. We present the case 28-year-old man who was successfully...

Erythema multiforme is an acute, immune-mediated, mucocutaneous condition in which 90% of cases are triggered by infection. The second most common cause drug-induced. It classically presents with itchy, burning targetoid lesions on the skin and mucous membranes. may be mistaken for other conditions, thus, rapid correct diagnosis crucial. often treated corticosteroids, though non-responders or those weakened immune systems require immunomodulatory therapy. We present case a 91-year-old male...

Clot in transit (CIT) is a rare condition which venous thromboembolism becomes lodged the right heart. It seen up to 18% of patients with massive pulmonary embolism, and if left untreated, mortality rates are between 80% 100%. The identification management CIT crucial. However, there no current guidelines for treatment CIT. We present case 44-year-old woman who was found have that ultimately treated medical management.Clot dangerous entity must be promptly managed.Risk factors include...

Transarterial chemoembolization (TACE) is a procedure reserved for the treatment of hepatocellular cancer that unresectable through surgery. It combines both embolization and chemotherapy by injecting via catheter directed at tumor then blocking artery to prevent blood flow tumor. We present case 69-year-old man who experienced post-embolization syndrome (PES) with hypertensive emergency elevated liver transaminases following his TACE procedure. Imaging combined clinical assessment was...

Multisystem inflammatory syndrome in adults (MIS-A) is a sequela of COVID-19 and can cause mixed cardiogenic vasodilatory shock. We present the case 34-year-old female who presented with shock was found to be influenza A positive while also meeting criteria for MIS-A. She responded well treatment steroids intravenous immunoglobulin (IVIG).

Mucosal melanoma represents a small proportion of all cases and is associated with worse prognosis. Primary malignant the lip (PMML) far less common, only few have been reported since 1997, most commonly in China, Japan, Uganda, India. Most these gene C-KIT. As result, treatment guidelines surrounding mucosal are unclear, especially complicated populations such as pregnant women. Mutations GNAQ GNA11 genes found to be uveal melanoma, while they rarely melanoma. We present case 23-year-old...

Inadvertent subclavian artery puncture during attempted central venous catheterization can be devastating. Percutaneous stent grafting, closure devices and conventional surgery have been described to effect repair. Balloon occlusion has also often recommended. Numerous publications advise use of balloon expanded no less than the diameter punctured artery.We describe case a 21 year-old male whose right was inadvertently after central-line removal. Our when purposely slightly smaller inner...

Abstract Background Cryptococcosis is a fungal infection that can cause pulmonary, central nervous system, or disseminated disease in immunosuppressed individuals. Although pulmonary cryptococcosis known to rarely affect immunocompetent patients, there limited research comparing the incidence and clinical outcomes of versus immunocompromised patients. Methods A retrospective analysis was performed on patients with confirmed positive CSF PCR, antigen, serum cryptococcal antigen tests from 8...

Inhalants are common drugs of abuse. Hydrocarbons, the active ingredient in most inhalants, exert depressant effects on central nervous system, causing a ‘high’. In heart, hydrocarbon toxicity can predispose patients to arrhythmias and heart failure through increased sympathetic susceptibility. We present case 28-year-old female who developed dilated cardiomyopathy setting chronic inhalant

Hirschsprung’s disease is caused by the failure of migration neural crest cells to hindgut, causing a lack development ganglion in submucosal and myenteric plexuses colonic wall. most often presents infants with pass meconium first two days life. We present case an eight-year-old male chronic constipation since birth who presented emergency department signs concerning spinal cord compression. To our knowledge, this such presenting urinary incontinence.