A5087579911- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Thermoregulation and physiological responses
- Lipid metabolism and biosynthesis
- Exercise and Physiological Responses
- Pancreatic function and diabetes
- Hemoglobin structure and function
- Nutrition and Health in Aging
- Diet and metabolism studies
- Heat Transfer and Optimization
- Erythrocyte Function and Pathophysiology
- Sports Performance and Training
- Neuroinflammation and Neurodegeneration Mechanisms
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Physical Activity and Health
- Metabolomics and Mass Spectrometry Studies
- Receptor Mechanisms and Signaling
- Health and Lifestyle Studies
- Nuclear Receptors and Signaling
- Cardiovascular Disease and Adiposity
- S100 Proteins and Annexins
- Metabolism, Diabetes, and Cancer
Vanderbilt University
2023-2024
University of Michigan
2018-2024
Michigan United
2023
Ann Arbor Center for Independent Living
2018-2021
University of Montana
2018
Abstract Objective We compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) on insulin sensitivity other important metabolic adaptations in adults with obesity. Methods Thirty-one inactive obesity (age: 31 ± 6 years; body mass index: 33 3 kg/m2) completed 12 weeks (4 sessions/week) either HIIT (10 × 1-minute at 90%HRmax, active recovery; n = 16) or MICT (45 minutes 70%HRmax; 15). To assess direct exercise independent weight/fat loss,...
Mammals are protected from changes in environmental temperature by altering energetic processes that modify heat production. Insulin is the dominant stimulus of glucose uptake and metabolism, which fundamental for thermogenic processes. The purpose this work was to determine interaction ambient induced energy expenditure (EE) on insulin sensitivity fluxes. Short-term adaptive responses thermoneutral (TN, ∼28°C) room (laboratory) (RT, ∼22°C) were studied mice. This range does not cause...
Excessive adipose tissue mass underlies much of the metabolic health complications in obesity. Although exercise training is known to improve individuals with obesity, effects without weight loss on structure and function remain unclear. Thirty-six adults obesity (body index = 33 ± 3 kg · m-2 ) were assigned 12 weeks (4 days week-1 either moderate-intensity continuous (MICT; 70% maximal heart rate, 45 min; n 17) or high-intensity interval (HIIT; 90% 10 × 1 19), maintaining their body...
The aims of this study were: 1) to assess relationships among insulin-mediated glucose uptake with standard clinical outcomes and deep-phenotyping measures (including fatty acid [FA] rate appearance [FA Ra] into the systemic circulation); 2) examine contribution adipocyte size, fibrosis, proteomic profile FA Ra regulation.
Abstract Excessive iron accumulation in metabolic organs such as the adipose tissue, liver, and skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages serve multiple roles including managing inflammatory tone regulating parachymal homeostasis; thus protecting against dysfunction upon overload. The scavenger receptor CD163 uniquely present on tissue-resident macrophages, plays a significant role homeostasis by clearing extracellular hemoglobin-haptoglobin...
Adipose tissue pathology in obese patients often features impaired adipogenesis, angiogenesis, and chronic low-grade inflammation, all of which are regulated large part by adipose stromal vascular cells (SVC; i.e. non-adipocyte within including preadipocytes, endothelial cells, immune cells). Exercise is known to increase subcutaneous lipolysis, but the impact exercise on SVCs has not been explored. The purpose this study was assess effects a session preadipocyte, cell, macrophage, T cell...
Excessive iron accumulation in metabolic organs such as the adipose tissue, liver, and skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages serve multiple roles including managing inflammatory tone regulating parachymal homeostasis; thus protecting against dysfunction upon overload. The scavenger receptor CD163 uniquely present on tissue-resident macrophages, plays a significant role homeostasis by clearing extracellular hemoglobin-haptoglobin complexes,...
New Findings What is the central question of this study? Obesity associated with complex perturbations to iron homeostasis: plasma ferritin concentration (a biomarker whole‐body stores) related abundance (the key tissue storage protein) in skeletal muscle adults obesity? main finding and its importance? Plasma was tightly correlated muscle, relationship persisted when accounting for sex, age, body mass index C‐reactive protein concentration. Our findings suggest that may be an important...
New Findings What is the central question of this study? Does exercise training modify tissue iron storage in adults with obesity? main finding and its importance? Twelve weeks moderate‐intensity or high‐intensity interval lowered whole‐body stores, decreased abundance key protein skeletal muscle (ferritin) tended to lower hepatic content. These findings show that can reduce obesity might have important implications for obese individuals dysregulated homeostasis. Abstract The regulation...
ABSTRACT Purpose This study determined the impact of an exercise-induced energy deficit on postprandial and 24 h glycemic control day after a session exercise. Methods Fifteen healthy participants (m/f = 5/10, 27 ± 6 yr, body mass index 3 kg·m −2 , peak oxygen consumption [V˙O 2peak ] 36 9 mL·kg −1 ·min ) completed two separate 5-d experimental trials performed under “free-living” conditions. On 1 each trial, were fitted with continuous glucose monitor abstained from Day 2 served as...
This study compared the effects of a single session high-intensity interval exercise versus moderate-intensity continuous on transcriptional changes in subcutaneous abdominal adipose tissue collected from adults with obesity. Our novel findings indicate upregulated inflammation-related gene sets, while it downregulated metabolism-related sets – after both and exercise. These data suggest can alter transcriptome 1 h ways that may impact inflammation metabolism.
Effective storage of excess energy in abdominal subcutaneous adipose tissue during periods overeating may help attenuate weight-gain-related insulin resistance. The objective this study was to assess changes the expression factors regulating capacity response a brief exposure nonobese adults. Because exercise can alter genes involved capacity, we compared responses regular exercisers (EX, n = 11) and nonexercisers (nonEX, 11). Abdominal samples oral glucose tolerance tests were performed...
ABSTRACT To examine factors underlying why most, but not all adults with obesity exhibit impaired insulin-mediated glucose uptake, we compared: 1) rates of fatty acid (FA) release from adipose tissue, 2) skeletal muscle lipid droplet (LD) characteristics, and 3) insulin signaling events in collected cohorts “HIGH” versus “LOW” sensitivity for uptake. Seventeen (BMI: 36±3kg/m 2 ) completed a 2h hyperinsulinemic-euglycemic clamp stable isotope tracer infusions to measure rate disappearance...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">Excessive iron accumulation in metabolic organs such as the adipose tissue, liver, and skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages serve multiple roles including managing inflammatory tone regulating parachymal homeostasis; thus protecting against dysfunction upon overload. The scavenger receptor CD163 uniquely present on tissue-resident macrophages, plays a significant role...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">Excessive iron accumulation in metabolic organs such as the adipose tissue, liver, and skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages serve multiple roles including managing inflammatory tone regulating parachymal homeostasis; thus protecting against dysfunction upon overload. The scavenger receptor CD163 uniquely present on tissue-resident macrophages, plays a significant role...
Abstract Aim To examine factors underlying why most, but not all, adults with obesity exhibit impaired insulin‐mediated glucose uptake, we compared: (1) adipose tissue fatty acid (FA) release, (2) skeletal muscle lipid droplet (LD) characteristics, and (3) insulin signalling events, in of relatively high versus low uptake. Methods Seventeen (BMI: 36 ± 3 kg/m 2 ) completed a h hyperinsulinemic–euglycemic clamp stable isotope tracer infusions to measure rate disappearance (glucose Rd) FA...
Exercise training modifies lipid metabolism in skeletal muscle, but the effect of exercise on intramyocellular droplet (LD) abundance, size, and intracellular distribution adults with obesity remains elusive. This study compared high-intensity interval (HIIT) more conventional moderate-intensity continuous (MICT) content, as well LD characteristics (size number) abundance within intramyofibrillar (IMF) subsarcolemmal (SS) regions type I II muscle fibers obesity. Thirty-six [body mass index...
ABSTRACT Mammals are protected from changes in environmental temperature by altering energetic processes that modify heat production. Insulin is the dominant stimulus of glucose uptake and metabolism, which fundamental for thermogenic processes. The purpose this work was to determine interaction ambient induced energy expenditure (EE) on insulin sensitivity fluxes. Short-term adaptive responses thermoneutral (TN, ∼28°C) room (laboratory) (RT, ∼22°C) were studied mice. This range does not...
Many metabolic health complications in obese adults are linked to abnormalities within their enlarged adipose tissue mass, which include hypertrophic adipocytes, a fibrotic extracellular matrix (ECM), and suppressed capillary density. Exercise training is first-line treatment for obesity-related diseases, but the direct effects of exercise on structure function remain unclear. The purpose this study was determine moderate-intensity continuous (MICT) high-intensity interval (HIIT)...