A5017265859- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Vitamin K Research Studies
- Clinical Laboratory Practices and Quality Control
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Plasma Applications and Diagnostics
- Healthcare Systems and Practices
- Proteoglycans and glycosaminoglycans research
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Practices and Patient Outcomes
- Wnt/β-catenin signaling in development and cancer
- Health, Medicine and Society
- Zoonotic diseases and public health
- Cancer-related gene regulation
- Myasthenia Gravis and Thymoma
- Viral gastroenteritis research and epidemiology
- Sphingolipid Metabolism and Signaling
- Diagnosis and Treatment of Venous Diseases
- Immunodeficiency and Autoimmune Disorders
- Electronic Health Records Systems
- Erythropoietin and Anemia Treatment
- Digital Imaging for Blood Diseases
Hôpital Rangueil
1999-2018
Université de Toulouse
2018
Groupe de Recherche en Énergie Électrique de Nancy
2017
Centre Hospitalier Universitaire de Toulouse
2005-2015
Université Paris Cité
2010
Hôtel-Dieu de Paris
2010
Inserm
2005-2010
Délégation Paris 5
2010
Hôpital Louis-Mourier
2010
Assistance Publique – Hôpitaux de Paris
2010
Summary The area under the thrombin generation curve (the endogenous potential; ETP) has been proposed as a parameter for plasma-based hypercoagulability and to monitor anticoagulant treatment. We present an ETP assay routine laboratory using centrifugal analyser. Throughput is 30 samples/h, within between run imprecision 4-5.6%. Suitable substrates were developed ranges of 10-500% 2-100% normal. Independent tissue factor concentration (if >4 pM), normal value extrinsic 384.8 ±51.7...
Understanding the role of gaseous environment in plasma–liquid interactions is crucial for multiple applications CAPs.
Introduction Cold plasma is a partially ionized gas generated by an electric field at atmospheric pressure that was initially used in medicine for decontamination and sterilization of inert surfaces. There currently growing interest using cold more direct medical applications, mainly due to the possibility tuning it obtain selective biological effects absence toxicity surrounding normal tissues,. While therapeutic potential chronic wound, blood coagulation, cancer treatment beginning be...
The current D-Dimer ELISA methods provide high sensitivity and negative predictive value for the diagnosis of deep vein thrombosis but these are not suitable emergency or individual determination. We have evaluated performance 3 newly available fast assays (Vidas D-Di, BioMérieux; Instant IA Stago; Nycocard D-Dimer, Nycomed) in comparison with classic (Stago, Organon, Behring) a Latex agglutination technique (Stago). One-hundred-and-seventy-one patients suspected presenting first episode...
Liver damage remains the most frequent type of adverse drug reaction (ADRs) that can lead to withdrawal a from market. The abnormal laboratory data identified by computerized hospital information systems be used in order improve detection ADRs. Our objectives were assess and incidence drug-induced liver abnormalities university inpatient population evaluate underreporting rate injury.We conducted prospective study performed 1 week per month June October 1997. We selected patients process...
To determine the effect of patient characteristics and specific guidelines that were developed for managing warfarin therapy in older adults included an in-house computer program on anticoagulation quality.Thirteen-month observational study.Acute care, extended rehabilitation geriatric wards a teaching hospital Paris, France.Hospitalized patients (N=307, mean age 86.1 +/- 6.1) treated with therapeutic international normalized ratio range 2.0 to 3.0.Patients assigned according care unit...
Plasminogen activators (tPA and uPA) are serine proteases that convert the circulating zymogen plasminogen to active plasmin mediate fibrin degradation. These multifunctional proteins trigger various biological events such as extracellular matrix degradation, cell adhesion, migration, proliferation, through not yet fully characterized mechanisms. We report that, in smooth muscle cells ECV-304 carcinoma cells, tPA ATF (the N-terminal catalytically inactive fragment of tPA) elicited DNA...
Due to large inter-individual variations, the dose of vitamin K antagonist required target desired hypocoagulability is hardly predictible for a given patient, and time needed reach therapeutic equilibrium may be excessively long. This work reports on simple method predicting daily maintenance fluindione after third intake. In first step, 37 patients were delivered 20 mg once day, at 6 p.m. 3 consecutive days. On morning 4th day an INR was performed. During following days adjusted between 2...
Abstract Besides its involvement in clot lysis, the plasminogen activator (PA) system elicits various cellular responses involved cell migration, adhesion, and proliferation plays a key role progression of cancers. β-Catenin interacts with E-cadherins functions as transcriptional coactivator Wnt-signaling pathway, which is implicated tumor formation when aberrantly activated. We report that tissue-type (tPA) elicited tyrosine phosphorylation cytosolic accumulation an active...
Cerebral malaria (CM) is the most severe manifestation of human yet still poorly understood. Mouse models have been developed to address subject. However, their relevance mimic pathogenesis largely debated. Here we study an alternative cerebral model with experimental Plasmodium berghei Keyberg 173 (K173) infection in Sprague Dawley rats. As Human, not all infected subjects showed malaria, 45% rats exhibiting Experimental Malaria (ECM) symptoms while majority (55%) remaining anemia and...
Summary. We report the pharmacodynamic properties of tinzaparin (175 U/kg antifactor Xa) given as a single daily administration for 5 consecutive days to 14 healthy volunteers known safe, effective treatment deep vein thrombosis and pulmonary embolism. The C max Xa (0·87 ± 0·15 U/ml) was associated with 2·4 0·5‐fold prolongation activated partial thromboplastin time (APTT) high antithrombin activity (0·38 0·1 U/ml). value 1·5‐ twofold lower than those generated by similar doses nadroparin...
Summary Venous thromboembolism may be efficiently treated by once-a-day (o.d.) administration of a high dose low molecular weight heparin (LMWH) instead the same total in two injections day (b.i. d.). To reduce volume subcutaneous (s.c.) injection, more concentrated form drug is advisable. This study was designed to compare bioavailability 2 formulations nadroparin containing 10,250 and 20,500 anti-Xa IU·ml-1 respectively. an open, randomized, cross-over where 12 healthy volunteers (age...
Active site‐inhibited factor VIIa (FFR‐rFVIIa) competes with (FVIIa) for binding to tissue (TF) and exerts an anti‐thrombotic effect. We report evaluation of the properties FFR‐rFVIIa in a model thrombosis involving two thrombogenic surfaces. Uncoated glass capillaries or coated TF were incorporated into arterioarterial shunt rat occlusion time (OT) was determined. An activity shown only on TF‐coated surface: OT significantly prolonged, from 167 ± 34 s control animals 312 42 after i.v. bolus...
The performance of the ABX Vega haematology analyser was compared with that Sysmex NE-8000, specific attention to flagging and ergonomics. Eight hundred routine samples underwent precision interinstrument variability studies 168 corresponding various blood disorders were studied meanwhile. Results from two instruments gave excellent correlation (r > 0.900) for most parameters except MCHC = 0.114), basophil monocyte percentages 0.617 0.552, respectively). reproducibility, repeatability,...