A5086955579- Spine and Intervertebral Disc Pathology
- Tribology and Lubrication Engineering
- Inflammatory mediators and NSAID effects
- Hydrogels: synthesis, properties, applications
- Advanced Chemical Sensor Technologies
- Musculoskeletal pain and rehabilitation
- Spondyloarthritis Studies and Treatments
- Spinal Hematomas and Complications
- Tribology and Wear Analysis
Washington University in St. Louis
2022
Intervertebral disc (IVD) degeneration is characterized by a loss of cellularity, and changes in cell-mediated activity that drives anatomic to IVD structure. In this study, we used single-cell RNA-sequencing analysis degenerating tissues the rat following lumbar puncture. Two control, uninjured IVDs (L2-3, L3-4) two degenerated, injured (L4-5, L5-6) from each animal were examined either at two- or eight-week post-operative time points. The cells these extracted transcriptionally profiled...
The synovium is a multilayer connective tissue separating the intra-articular spaces of diarthrodial joint from extra-synovial vascular and lymphatic supply. Synovium regulates drug transport into out joint, yet its material properties remain poorly characterized. Here, we measured compressive (aggregate modulus, Young's Poisson's ratio) hydraulic permeability with combined experimental-computational approach. A aggregate modulus for solid phase were quantified linear regression equilibrium...
ABSTRACT Intervertebral disc (IVD) degeneration is characterized by a loss of cellularity, and changes in cell-mediated activity that drives anatomic to IVD structure. In this study, we use single cell RNA-sequencing analysis cells extracted from the degenerating tissues rat following lumbar puncture. Two control, uninjured IVDs (L2-3, L3-4) two degenerated, injured (L4-5, L5-6) each animal were examined either at two- eight-week post-operative time points. The these transcriptionally...