A5058328227- Muscle Physiology and Disorders
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Neurobiology and Insect Physiology Research
- Peripheral Artery Disease Management
The University of Texas Health Science Center at Houston
2022-2023
Brown Foundation
2022-2023
Background Peripheral arterial disease and critical limb ischemia are cardiovascular complications associated with vascular insufficiency, oxidative metabolic dysfunction, myopathy in the limbs. Estrogen-related receptor gamma (ERRγ) has emerged as a dual regulator of paracrine angiogenesis metabolism through transgenic mouse studies. Here our objective was to investigate whether postischemic intramuscular targeting ERRγ via gene therapy promotes ischemic recovery preclinical model...
Abstract Transcriptional determinants in the skeletal muscle that govern exercise capacity, while poorly defined, could provide molecular insights into how improves fitness. Here, we have elucidated role of nuclear receptors, estrogen‐related receptor alpha and gamma (ERRα/γ) regulating myofibrillar composition, contractility, capacity muscle. We used muscle‐specific single or double (DKO) ERRα/γ knockout mice to investigate effect deletion on parameters. Individual did not a significant...
Obesity and type II diabetes are leading causes of peripheral arterial disease (PAD), which is characterized by vascular insufficiency ischemic damage in the limb skeletal muscle. Glycemic control not sufficient to prevent progression PAD, molecular targets that can promote muscle neo-angiogenesis obesity remain poorly defined. Here, we have investigated whether nuclear receptor estrogen-related alpha (ERRα) revascularization muscles diet-induced obese (DIO) mice. Using muscle-specific ERRα...
Peripheral arterial disease (PAD) and critical limb ischemia (CLI) are caused by occlusion of blood vessels characterized muscle ischemia, weakness, myopathy. Over 8-12 million Americans affected PAD, resulting in impaired mobility, increased cardiovascular risk, amputation. Therapeutic strategies for simultaneously restoring flow, metabolism, recovery currently lacking PAD. We have previously shown a transgenic mouse model that nuclear receptor Estrogen-related gamma (ERRγ) is central...