A5064979282- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- MicroRNA in disease regulation
- Maternal and fetal healthcare
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Grief, Bereavement, and Mental Health
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Health and Technologies
- Female Genital Mutilation/Cutting Issues
- Diet and metabolism studies
- Kidney Stones and Urolithiasis Treatments
- Epigenetics and DNA Methylation
- Maternal and Perinatal Health Interventions
- Circular RNAs in diseases
- Ureteral procedures and complications
- Autophagy in Disease and Therapy
Université d'Angers
2017-2024
Centre Hospitalier Universitaire d'Angers
2015-2024
Centre hospitalier universitaire de Québec
2018
Université Laval
2018
Institut Galien Paris-Saclay
2012
Endometriosis diagnosis constitutes a considerable economic burden for the healthcare system with diagnostic tools often inconclusive insufficient accuracy. We sought to analyze human miRNAome define saliva-based miRNA signature endometriosis.
Abstract Endometriosis—a systemic and chronic condition occurring in women of childbearing age—is a highly enigmatic disease with unresolved questions. While multiple biomarkers, genomic analysis, questionnaires, imaging techniques have been advocated as screening triage tests for endometriosis to replace diagnostic laparoscopy, none implemented routinely clinical practice. We investigated the use machine learning algorithms (MLA) diagnosis based on 16 key patient-based symptom features. The...
BackgroundThe discovery of a saliva-based micro–ribonucleic acid (miRNA) signature for endometriosis in 2022 opened up new perspectives early and noninvasive diagnosis the disease. The 109-miRNA saliva is product miRNA biomarkers artificial intelligence (AI) modeling. We designed multicenter study to provide external validation its diagnostic accuracy. present here an interim analysis.MethodsThe first 200 patients included prospective ENDOmiRNA Saliva Test (NCT05244668) were analysis....
Endometriosis and infertility are closely linked, but the underlying mechanisms still poorly understood. This study aimed to evaluate impact of endometriosis on in vitro fertilization (IVF) parameters, especially embryo quality IVF outcomes. A total 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 969 without endometriosis. Women had significantly lower ovarian reserve markers (AMH AFC), regardless previous surgery. Despite receiving higher...
The aim of our study was to describe the bioinformatics approach analyze miRNome with Next Generation Sequencing (NGS) 200 plasma samples from patients and without endometriosis. Patients were prospectively included in ENDO-miRNA that selected pelvic pain suggestive miRNA sequencing performed using an Novaseq6000 sequencer (Illumina, San Diego, CA, USA). Small RNA-seq yielded ~4228 M raw reads. A total 2633 miRNAs found differentially expressed. Among them, 8.6% (n = 229) up- or...
To date, there is no consensus on the ideal management strategy of patients with poor ovarian response (POR) to controlled stimulation (COS) for in vitro fertilization (IVF). Currently, these are given choice of: (1) canceling cycle; (2) proceeding COS regardless response, and performing oocyte retrieval transfer embryos when available; or (3) conversion an intrauterine insemination (IUI). When decision proceed cycle taken, it not clear whether IVF IUI best choice. If live birth rates were...
Background and Objectives:Laparoscopic hysterectomy poses the risk of lower urinary tract injury, intraoperative recognition injury is often difficult. We sought to evaluate sodium fluorescein coloration ureteral jets during cystoscopy after laparoscopic surgeons' satisfaction with this method detection.Methods:This was an observational study, in which data were collected prospectively. A total 30 women who underwent from August 2016 February 2017 at Centre Hospitalier de l'Université Laval...
To describe transvaginal radiofrequency ablation of myomas (TRAM) in 10 key steps.