A5041564058- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Retinal Development and Disorders
- Telemedicine and Telehealth Implementation
- Vascular Malformations Diagnosis and Treatment
- Nausea and vomiting management
- Patient Satisfaction in Healthcare
- Optical Coherence Tomography Applications
- Retinopathy of Prematurity Studies
- Healthcare Operations and Scheduling Optimization
- Medical Coding and Health Information
- Atherosclerosis and Cardiovascular Diseases
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Ophthalmology and Visual Health Research
- Connexins and lens biology
- Sinusitis and nasal conditions
Boston University
2014-2025
Boston Medical Center
2010-2025
University School
2011-2023
Versus Arthritis
2022
VA Boston Healthcare System
2008-2010
Creedmoor Psychiatric Center
2010
Ophthalmic Consultants of Boston
2003-2006
Tufts University
2003-2006
University of Kansas Medical Center
2001
Importance Several ophthalmic diseases disproportionately affect racial and ethnic minority patients, yet most clinical trials struggle to enroll cohorts that are demographically representative of disease burden; some barriers recruitment include time transportation, language cultural differences, fear mistrust research due historical abuses. Incorporating diversity within the team has been proposed as a method increase trust improve engagement among potential study participants. Objective...
In this study, we compare the vitreous cytokine profile in patients with proliferative diabetic retinopathy (PDR) to that of without PDR. The identification novel cytokines involved pathogenesis PDR provides candidate therapeutic targets may stand alone or work synergistically current therapies management retinopathy. Undiluted humor specimens were collected from 74 undergoing vitrectomy for various vitreoretinal disorders. Quantitative immunoassay was performed a panel 36 neuroinflammatory...
Importance The hybrid ophthalmology telemedicine model asynchronously pairs an imaging appointment by a technician with subsequent virtual clinician. Although it has been mentioned in several studies as alternative to standard in-person care during the COVID-19 pandemic, outcomes of this clinical remain be evaluated. Objective To investigate associated pandemic for nonurgent and nonprocedural ophthalmological care. Design, Setting, Participants Retrospective, cross-sectional study all visits...
The eye may serve as source for diagnostic testing early detection of Alzheimer's disease (AD). Examination amyloid-β (Aβ) and tau protein content in human vitreous its correlation to neuro-cognition improve ocular-based AD methods. To evaluate levels Aβ humor investigate the clinical predictive role these proteins markers AD. A prospective, single-center, multi-surgeon cohort study. Vitreous samples from 80 eyes were measured quantitatively Aβ40-42, pTau, tTau. Linear regression was used...
Protein biomarkers have been broadly investigated in cerebrospinal fluid and blood for the detection of neurodegenerative diseases, yet a clinically useful diagnostic test to detect early, pre-symptomatic Alzheimer's disease (AD) remains elusive. We conducted this study quantify Aβ40, Aβ42, total Tau (t-Tau), hyperphosphorylated (ptau181), glial fibrillary acidic protein (GFAP) neurofilament light chain (NfL) eye fluids relative blood. In cross-sectional we collected vitreous humor, aqueous...
In a university ophthalmology department, cluster of postoperative diplopia and ptosis cases occurred in the initial 3 months after hyaluronidase (Wydase) became unavailable for use with injection anesthesia. These suggest that hyaluronidase, when used anesthesia, may protect extraocular muscles nerves from toxic effects local anesthetic agents. The spreading action facilitates uniform diffusion This prevents elevated extracellular tissue pressure, cause ischemic damage to or nerves....
A dual-channel optical coherence tomography system with wavelengths in the visible and near-infrared light ranges can provide both structural functional information for retinal microvasculature simultaneously. We applied this integrated an ongoing clinical study of patients various pathologies. Here, we present case results diabetic retinopathy, central vein occlusion, sickle cell retinopathy compared to a healthy subject. For first time, comparison validates system’s ability detect...
Abstract Background Neurofilament light chain (NfL) is a promising biomarker of neurodegeneration in the cerebrospinal fluid and blood. This study investigated presence NfL vitreous humor its associations with amyloid beta, tau, inflammatory cytokines vascular proteins, apolipoprotein E ( APOE ) genotypes, Mini-Mental State Examination (MMSE) scores, systemic disease, ophthalmic diseases. Methods single-site, prospective, cross-sectional cohort study. Undiluted (0.5–1.0 mL) was aspirated...
Background: Patients with eye disease have an increased risk for developing neurodegenerative disease. Neurodegenerative proteins can be measured in the eye; however, correlations between biomarker levels fluid and neuropathological diagnoses not been established. Objective: This exploratory, retrospective study examined vitreous humor from 41 postmortem eyes brain tissue of Alzheimer’s (AD, n = 7), chronic traumatic encephalopathy (CTE, 15), both AD + CTE (n 10), without significant...