A5101584416- Genomics and Chromatin Dynamics
- Retinal Development and Disorders
- Cancer-related gene regulation
- Herpesvirus Infections and Treatments
- Epigenetics and DNA Methylation
- Ocular Oncology and Treatments
- Retinoids in leukemia and cellular processes
- Click Chemistry and Applications
- Electrowetting and Microfluidic Technologies
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Biosensors and Analytical Detection
- Protein Degradation and Inhibitors
- Water Quality Monitoring Technologies
University of Hong Kong
2023
Xiamen University
2017-2020
Sichuan Agricultural University
2017
Collaborative Innovation Center of Chemistry for Energy Materials
2017
An integrated distance-based origami paper analytical device (ID-oPAD) is developed for simple, user friendly and visual detection of targets interest. The platform enables complete integration target recognition, signal amplification, output based on aptamer/invertase-functionalized sepharose beads, cascaded enzymatic reactions, a 3D microfluidic paper-based with readout, respectively. invertase-DNA conjugate released upon addition, after which it permeates through the cellulose flows down...
Methylation of histone H3 lysine-79 (H3K79) is an epigenetic mark for gene regulation in development, cellular differentiation, and disease progression. However, how this translated into downstream effects remains poorly understood owing to a lack knowledge about its readers. We developed nucleosome-based photoaffinity probe capture proteins that recognize H3K79 dimethylation (H3K79me2) nucleosomal context. In combination with quantitative proteomics approach, identified menin as H3K79me2...
Fowl adenovirus (FAdV) has caused significant losses in chicken flocks throughout China recent years. However, the current understanding of genetic and pathogenic characteristics FAdV epidemic southwestern remains poorly understood. In this study, a total 22 strains were isolated from liver samples diseased chickens farms China. Phylogenetic analysis based on hexon loop-1 gene showed that isolates clustered into four distinct serotypes: serotype 4 (FAdV-4) (86.4%, 19/22), FAdV-2 (4.5%,...
Disrupted clearance of all-trans-retinal (atRAL), a component the visual (retinoid) cycle in retina, may cause photoreceptor atrophy autosomal recessive Stargardt disease (STGD1) and dry age-related macular degeneration (AMD). However, mechanisms underlying atRAL-induced loss remain elusive. Here, we report that atRAL activates c-Jun N-terminal kinase (JNK) signaling at least partially through reactive oxygen species production, which promoted mitochondria-mediated caspase- DNA...
Various proteins bind to chromatin regulate DNA and its associated processes such as replication, transcription, damage repair. The identification characterization of these chromatin-associating remain a challenge, their interactions with often occur within the context local nucleosome or structure, which makes conventional peptide-based strategies unsuitable. Here, we developed simple robust protein labeling chemistry prepare synthetic multifunctional nucleosomes that carry photoreactive...