A5077874396- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Migraine and Headache Studies
- Nicotinic Acetylcholine Receptors Study
- Neural and Behavioral Psychology Studies
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Muscle activation and electromyography studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Geophysics and Gravity Measurements
- Advanced Memory and Neural Computing
- Cognitive Science and Education Research
- Neuroscience and Music Perception
- Neural Networks and Applications
- Trigeminal Neuralgia and Treatments
- Tactile and Sensory Interactions
- Advanced MRI Techniques and Applications
University of California, Davis
2025
KU Leuven
2017-2024
VIB-KU Leuven Center for Brain & Disease Research
2019-2024
Allen Institute for Brain Science
2023
Vrije Universiteit Amsterdam
2015
The size and shape of dendrites axons are strong determinants neuronal information processing. Our knowledge on structure function is primarily based brains laboratory animals. Whether it translates to human not known since quantitative data "full" morphologies lacking. Here, we obtained brain tissue during resection surgery reconstructed basal apical individual neurons across all cortical layers in temporal cortex (Brodmann area 21). Importantly, did correlate etiology, disease severity, or...
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method which has been shown to modulate hearing, motor, cognitive and memory function. However, the mechanisms underpinning these findings are controversial, as studies show that reaching cortex may not be strong enough entrain neural activity. Here, we propose new hypothesis reconcile opposing results: tACS effects caused by transcutaneous of peripheral nerves in skin transcranial cortical neurons. Rhythmic...
BackgroundTranscranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that can modulate many brain functions including learning and memory. Recent evidence suggests tDCS memory effects may be caused by co-stimulation of scalp nerves such as the trigeminal nerve (TN), not electric field in brain. The TN gives input to brainstem nuclei, locus coeruleus controls noradrenaline release across regions, hippocampus. However, (TN-DCS) are currently well...
Abstract Dynamical system models have proven useful for decoding the current brain state from neural activity. So far, neuroscience has largely relied on either linear or nonlinear based artificial networks. Piecewise approximations of dynamics in other technical applications, providing a clear advantage over network-based models, when dynamical is not only supposed to be observed, but also controlled. Here we explore whether piecewise-linear (recurrent Switching Linear System rSLDS models)...
Objectives: We aimed to investigate the impact of acute cortical stroke (ACS) on neural activity in subthalamic nucleus (STN). then examined correlation between changes STN and motor disability. Methods: Forty-four Sprague-Dawley rats were used. While anesthetized, we inserted electrodes induced an ACS by creating photothrombotic lesion ipsilateral cortex. Local field potentials recorded before after ACS. The behavior was assessed using single pellet reaching task. Results: Rats experienced...
Transcranial alternating current stimulation (tACS) uses sinusoidal, subthreshold, electric fields to modulate cortical processing. Cortical processing depends on a fine balance between excitation and inhibition tACS acts both excitatory inhibitory neurons. Given this, it is not clear whether should increase or decrease excitability. We investigated this using transcranial of the rat (all males) motor cortex consisting continuous subthreshold sine wave with short bursts suprathreshold...
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation method that has been used to alter cognition in hundreds of experiments. During tDCS, low-amplitude delivered via scalp electrodes create weak electric field the brain. The causes membrane polarization cortical neurons directly under electrodes. It generally assumed this mechanism observed effects tDCS on cognition. However, it was recently shown some are not caused by brain but rather co-stimulation cranial and...
Abstract Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that can entrain physiological tremor in healthy volunteers. We conducted two experiments to investigate the effectiveness of high-amplitude and focused tACS montages at entraining tremor. Experiment 1 used saline-soaked sponge electrodes with an extra-cephalic return electrode compared effects motor (MC) prefrontal cortex (PFC) location. Average peak-amplitude was 1.925 mA. 2 gel-filled...
Invasive cortical stimulation (ICS) is a neuromodulation method in which electrodes are implanted on the cortex to deliver chronic stimulation. ICS has been used treat neurological disorders such as neuropathic pain, epilepsy, movement and tinnitus. Noninvasive methods transcranial magnetic electrical (TES) show great promise treating some require no surgery. However, only acute can be delivered. Epicranial current (ECS) novel concept for delivering through subcutaneous skull. The use of...
Background: Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that can modulate many brain functions including learning and memory. Recent evidence suggests tDCS memory effects may be caused by co-stimulation of scalp nerves such as the trigeminal nerve (TN), not electric field in brain. The TN gives input to brainstem nuclei, locus coeruleus controls noradrenaline release across regions , hippocampus. However, (TN-DCS) are currently well...
tDCS is widely assumed to cause neuromodulation via the electric field in cortex acting directly on cortical neurons. However, recent evidence suggests that may indirectly influence brain activity through cranial nerve pathways, notably trigeminal nerve, but these neuromodulatory pathways remain unexplored. To investigate first stages this potential pathway we developed an animal model study effect of direct current stimulation (TN-DCS) neuronal principal sensory nucleus (NVsnpr) and...
Since the inception of DBS, cathodic pulses have been used.To investigate effect anodic and symmetric biphasic on therapeutic window (TW) in essential tremor (ET) patients.A randomized, doubled-blinded, cross-over design was used to test cathodic, (cathode-first anode-first) TW an acute clinical setting. defined as difference between minimal stimulation amplitude provoking side effects inducing arrest.9 ET patients (10 hemispheres) were included. Anodic induced a significantly larger...
Abstract Background Recent evidence suggests that transcranial direct current stimulation (tDCS) indirectly influences brain activity through cranial nerve pathways, particularly the trigeminal nerve. However, electrophysiological effects of (DC) on (DC-TNS) and its impact nuclei remain unknown. These exert control over brainstem centers regulating neurotransmitter release, such as serotonin norepinephrine, potentially affecting global activity. Objectives To investigate how DC-TNS impacts...
Neural entrainment is the phase synchronization of a population neurons to an external rhythmic stimulus such as applied in context transcranial alternating current stimulation (tACS). tACS can cause profound effects on human behavior. However, there remain significant number studies that find no behavioral effect when subjects. To investigate this discrepancy, we time sensitive lock value (PLV) based analysis single unit data from rat motor cortex. The revealed detection neural depends...
Single neurons often exhibit endogenous oscillatory activity centered around a specific frequency band. Transcranial alternating current stimulation (tACS) can generate weak oscillating extracellular field in the brain that causes subthreshold membrane potential shifts affect spike timing at single neuron level. Many studies have now shown oscillation be entrained when tACS matches of exogenous field. However, effect on amplitude has been less well studied. We investigated this by using...
Abstract Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that can modulate many brain functions including learning and memory. Recent evidence suggests tDCS memory effects may be caused by co-stimulation of scalp nerves such as the trigeminal nerve (TN), not electric field in brain. The TN gives input to brainstem nuclei, locus coeruleus controls noradrenaline release across regions, hippocampus. However, (TN-DCS) are currently well understood. In this...
Abstract Introduction Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation method using low amplitude (1-2 mA) to create weak electric fields (<1 V/m) in the brain, influencing cognition, motor skills, and behavior. However, neural mechanisms remain unclear, as prior studies used high field strengths (10–40 unrepresentative of human tDCS. Objective This study aimed develop an in-vivo rat model replicating tDCS examine effects on cortical neurons. Method...
Background: Epicranial cortical stimulation (ECS) is a minimally invasive neuromodulation technique that works by passing electric current between subcutaneous electrodes positioned on the skull. ECS causes stronger and more focused field in cortex compared to transcranial (TES) where are placed scalp. However, it unknown if can target deeper regions fields become relatively weak broad. Recently, interferential (IF) using scalp has been proposed as novel subcortical regions. During IF, two...
Objective. We present a framework to objectively test and compare stimulation artefact removal techniques in the context of neural spike sorting.Approach. To this end, we used realistic hybrid ground-truth spiking data, with superimposed artefacts fromin vivorecordings. evaluate several techniques: blanking, template subtraction by averaging, linear regression, multi-channel Wiener filter (MWF).Main results. Our study demonstrates that blanking result poorer sorting performance than...