A5023407804- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- SARS-CoV-2 and COVID-19 Research
- Asphalt Pavement Performance Evaluation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Infrastructure Maintenance and Monitoring
- Photonic and Optical Devices
- Molecular Junctions and Nanostructures
- Electrochemical sensors and biosensors
- Optical Coatings and Gratings
- Advanced Fiber Optic Sensors
- SARS-CoV-2 detection and testing
- Monoclonal and Polyclonal Antibodies Research
- Mass Spectrometry Techniques and Applications
- Ionic liquids properties and applications
- Polymer Surface Interaction Studies
- Nanocluster Synthesis and Applications
- Nanofabrication and Lithography Techniques
- Quantum Dots Synthesis And Properties
- Analytical Chemistry and Chromatography
Regroupement Québécois sur les Matériaux de Pointe
2017-2025
Université de Montréal
2016-2025
Centre québécois sur les matériaux fonctionnels
2017-2024
Centre for Interdisciplinary Research in Rehabilitation
2024
Centre of Excellence for Advanced Materials
2017-2021
Département de Chimie Moléculaire
2015-2020
Dalian University of Technology
2019
Université de Sherbrooke
2017
Centre de Mathématiques Laurent Schwartz
2017
McGill University
2010-2016
The design and application of sensors for monitoring biomolecules in clinical samples is a common goal the sensing research community. Surface plasmon resonance (SPR) other plasmonic techniques such as localized surface (LSPR) imaging SPR are reaching maturity level sufficient their samples. In recent years, first examples antibodies, proteins, enzymes, drugs, small molecules, peptides, nucleic acids biofluids collected from patients afflicted with series medical conditions (Alzheimer's,...
Physical chemistry, materials science, analytical chemistry and engineering greatly contributed to the increasing popularity of bioanalytical biophysical applications surface plasmon resonance (SPR) by providing novel materials, instrumental concepts, theory further understand plasmonic phenomenon support innovation in SPR. This perspective article portrays contemporary state SPR-based techniques establishes a list challenges be overcome for improving plasmonics resonance.
A low-cost methodology to prepare highly sensitive sensors is reported with different nanoparticles for LSPR and SERS measurements. The sensor was self-assembled as an array of polystyrene-capped gold (Au NPs), produced by drop-coating a Au NP suspension on glass surface followed plasma etching the polystyrene. procedure applied sizes shapes NPs, primarily 60 nm nanospheres 80 nanoraspberries, created precise control packing density array. sensitivity figure merit (FOM) arrays...
Silver has been demonstrated to be a powerful cationization agent in mass spectrometry (MS) for various olefinic species such as cholesterol and fatty acids. This work explores the utility of metallic silver sputtering on tissue sections high resolution imaging (IMS) olefins by laser desorption ionization (LDI). For this purpose, sputtered coating thickness was optimized an assorted selection mouse rat tissues including brain, kidney, liver, testis. brain section, adjusted 23 ± 2 nm prevent...
We monitored metabolite secretion near living cells using a plasmonic nanosensor. The nanosensor created from borosilicate nanopipettes analogous to the patch clamp was decorated with Au nanoparticles and served as surface-enhanced Raman scattering (SERS) substrate addressable location. With this nanosensor, we acquired SERS locally Madin-Darby canine kidney (MDCKII) epithelial cells, detected multiple metabolites, such pyruvate, lactate, ATP, urea simultaneously. These nanosensors were...
The extracellular environment is a complex medium in which cells secrete and consume metabolites. Molecular gradients are thereby created near cells, triggering various biological physiological responses. However, investigating these molecular remains challenging because the current tools ill-suited provide poor temporal special resolution while also being destructive. Herein, we report development application of machine learning approach combination with surface-enhanced Raman spectroscopy...
Dense arrays of well-dispersed gold nanoparticles (AuNPs) on optical fibers are shown to bridge the gap in sensitivity and sensing performance between localized surface plasmon resonance (LSPR) classical SPR sensing. A simple self-assembly method relying a poly(styrene- b-4-vinylpyridine) (PS- b-P4VP) block copolymer brush layer was used immobilize AuNPs different diameters from 10 92 nm fibers. In comparison with standard AuNP deposition methods using (3-aminopropyl)trimethoxysilane (APTMS)...
As a highly toxic heavy metal ion, divalent mercuric ion (Hg2+) is one of the most widely diffused and hazardous environmental pollutants. In this work, simple, portable, inexpensive fiber-optic sensor based on surface plasmon resonance (SPR) effect was developed for Hg2+ detection, which takes advantage 4-mercaptopyridine (4-MPY)-functionalized Au nanoparticles (Au NPs/4-MPY) as signal amplification tag. Based coordination between nitrogen in pyridine moiety, we by self-assembling 4-MPY...
CD36 transmembrane proteins have diverse roles in lipid uptake, cell adhesion and pathogen sensing. Despite numerous vitro studies, how they act native cellular contexts is poorly understood. A Drosophila homologue, sensory neuron membrane protein 1 (SNMP1), was previously shown to facilitate detection of lipid-derived pheromones by their cognate receptors olfactory cilia. Here we investigate SNMP1 functions vivo. Structure-activity dissection demonstrates that SNMP1's ectodomain essential,...
We describe surface-enhanced Raman spectroscopy (SERS) aptasensors that can indirectly detect MC-LR and MC-RR, individually or simultaneously, in natural water algal culture. The sensor is constructed from nanoparticles composed of successive layers Au core–SERS label–silver shell–gold shell (Au@label@Ag@Au NPs), functionalized on the outer surface by and/or MC-RR aptamers. These NPs are immobilized asymmetric nanoflowers (AuNFs) dispersed planar silicon substrates through DNA hybridization...
The volume phase transition (VPT) behavior of individual thermally responsive poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAm-co-AAc) hydrogel microparticles was studied by in-situ dynamic mode atomic force microscopy (AFM) and spectroscopy during heating cooling cycles. Hydrogel samples were prepared electrostatic immobilization to amine-modified gold surfaces. AFM studies particle deswelling performed varying the applied on particles imaging as a function geometry material probe....
Near-zero fouling monolayers based on binary patterned peptides allow low nanomolar detection of the matrix metalloproteinase-3 (MMP-3) directly in crude bovine serum, without sample pretreatment, secondary antibody or signal amplification. The peptide 3-MPA-HHHDD-OH (3-MPA, 3-mercaptopropionic acid) was found optimal compared to other 3-MPA-Ax-By-OH, where 0 ≤ x, y 5, and x + = PEG. In this study, amino acid A His, Asp, Ser, Leu, B Ser. Zwitterionic exhibited excellent resistance...
Nanomaterials developed for localized surface plasmon resonance (LSPR) are increasingly integrated to classical prism-based SPR sensors, providing enhanced sensitivity and lower detection limits. The unique properties of these novel nanomaterials in addition chemistry minimize nonspecific adsorption plasmon-coupled techniques with other spectroscopic or mass spectrometry highlighted this article.