A5079904041- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- interferon and immune responses
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Immune Response and Inflammation
- Salivary Gland Disorders and Functions
- Viral-associated cancers and disorders
National Clinical Research Center for Digestive Diseases
2024
First Affiliated Hospital Zhejiang University
2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
Central South University
2022-2024
Zhejiang University
2024
Zhejiang Chinese Medical University
2023
Monkeypox has been spreading worldwide since May 2022, when the World Health Organization (WHO) declared outbreak a "public health emergency of international concern." The spread monkeypox posed serious threat to people around world, but few studies have conducted, and molecular mechanism after infection remains unclear. We therefore implemented transcriptome analysis identify signaling pathways biomarkers in monkeypox-infected cells help understand monkeypox-host cell interactions. In this...
Hepatitis B viral (HBV) persistent infection plays a significant role in hepatocellular carcinoma (HCC) tumorigenesis. Many studies have revealed the pivotal roles of N6-methyladenosine (m6A) multiple cancers, while regulatory mechanism stemness maintenance HBV infection-related HCC remains elusive. Here, we demonstrated that level m6A modification was downregulated by HBV-positive HCC, through enhanced stability ALKBH5 mRNA. More specifically, also identified mRNA functionally required for...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related mortality worldwide, with Hepatitis B virus (HBV) infection being cause. This study aims to investigate role HBV in HCC pathogenesis involving glucose metabolism. Long non-coding RNA (lncRNA) OIP5-AS1 was significantly downregulated HBV-positive patients, and its low expression indicated a poor prognosis. lncRNA primarily localized cytoplasm, acting as tumor suppressor. protein X (HBx) repressed by inhibiting...
Hepatitis B virus (HBV)-associated liver cirrhosis (LC), a common condition with high incidence and mortality rates, is often associated diabetes mellitus (DM). However, the molecular mechanisms underlying impaired glucose regulation during HBV-associated LC remain unclear. Data from 63 patients 62 LC-associated DM were analysed. Co-culture of NK cells islet β cell lines used to study mechanism. A mouse model was verify effect S100A8/A9 on regulation. Higher levels interferon (IFN)-γ derived...
Abstract Monkeypox has been spreading worldwide since May 2022, when the World Health Organization (WHO) declared outbreak of a “Public health emergency international concern”. The spread monkeypox posed serious threat to people all over world but few studies have carried out on it, and molecular mechanism after infection remains unclear. We therefore implemented transcriptome analysis identify signaling pathways biomarkers in monkeypox-infected cells help understand monkeypox-host cell...
<div>Abstract<p>Hepatitis B viral (HBV) persistent infection plays a significant role in hepatocellular carcinoma (HCC) tumorigenesis. Many studies have revealed the pivotal roles of N6-methyladenosine (m6A) multiple cancers, while regulatory mechanism stemness maintenance HBV infection-related HCC remains elusive. Here, we demonstrated that level m6A modification was downregulated by HBV-positive HCC, through enhanced stability ALKBH5 mRNA. More specifically, also identified...
<div>Abstract<p>Hepatitis B viral (HBV) persistent infection plays a significant role in hepatocellular carcinoma (HCC) tumorigenesis. Many studies have revealed the pivotal roles of N6-methyladenosine (m6A) multiple cancers, while regulatory mechanism stemness maintenance HBV infection-related HCC remains elusive. Here, we demonstrated that level m6A modification was downregulated by HBV-positive HCC, through enhanced stability ALKBH5 mRNA. More specifically, also identified...
<p>Supplementary Figure S3 shows the extended data of "ALKBH5 is required for maintenance hepatoma cell self-renewal in HBV-positive HCC"</p>
<p>Supplementary Figure S2 shows the extended data of "HBV up-regulated ALKBH5 in HBV-positive HCC"</p>
<p>Supplementary Figure S4 shows the extended data of "ALKBH5-mediated m6A demethylation in 3’UTR region SNAI2 mRNA is recognized by YTHDF2"</p>
<p>Supplementary Figure S5 shows the extended data of "SLUG reversed stemness properties and immune escape induced by ALKBH5"</p>
<p>Supplementary Figure S1 shows the extended data of "Enhanced malignancy and declined m6A levels in HBV-related HCC"</p>
<p>Supplementary Figure S4 shows the extended data of "ALKBH5-mediated m6A demethylation in 3’UTR region SNAI2 mRNA is recognized by YTHDF2"</p>
<p>Supplementary Figure S3 shows the extended data of "ALKBH5 is required for maintenance hepatoma cell self-renewal in HBV-positive HCC"</p>
<p>Supplementary Figure S2 shows the extended data of "HBV up-regulated ALKBH5 in HBV-positive HCC"</p>
<p>Supplementary Figure S5 shows the extended data of "SLUG reversed stemness properties and immune escape induced by ALKBH5"</p>
<p>Supplementary Figure S1 shows the extended data of "Enhanced malignancy and declined m6A levels in HBV-related HCC"</p>
Amino acid metabolism in T cells determines the therapeutic efficacy of T-cell-targeting drugs. To assess direction amino and construct related knowledge structure, we performed a bibliometric analysis aiming at utilizing studies publicized last 15 years. 337 were downloaded from Web Science Core Collection, information on countries, institutes, authors was collected analyzed. In addition, present research status future trends explored according to results yielded cited references keywords....
Abstract Background: Autoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components known to affect the course of autoimmune diseases. Intestinal microorganisms can be dynamically regulated through diet, this study combines intestinal with diseases open up new therapeutic ideas. Methods: In Lewis rats, a model Experimental Neuritis（EAN）was established P0 peptide, Lactobacillus were used as treatment, serum T-cell ratio,...