A5101434201- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Protein Kinase Regulation and GTPase Signaling
- Cellular transport and secretion
- Nuts composition and effects
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Child Nutrition and Feeding Issues
- Erythrocyte Function and Pathophysiology
- Adenosine and Purinergic Signaling
- Endoplasmic Reticulum Stress and Disease
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Biotin and Related Studies
- Prion Diseases and Protein Misfolding
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
- Congenital heart defects research
- Biochemical effects in animals
- Bat Biology and Ecology Studies
- Cellular Mechanics and Interactions
- Ion channel regulation and function
New York State Office for People With Developmental Disabilities
2011-2021
Universidad Autónoma de Madrid
2005
Yerevan State University
2005
Sapienza University of Rome
2005
Chinese PLA General Hospital
2005
National Institute of Advanced Industrial Science and Technology
2005
University of Florence
2005
University of Bologna
2005
New York State Department of State
1993-2002
Osaka University
2002
Autism is a severe developmental disorder with poorly understood etiology. Oxidative stress in autism has been studied at the membrane level and also by measuring products of lipid peroxidation, detoxifying agents (such as glutathione), antioxidants involved defense system against reactive oxygen species (ROS). Lipid peroxidation markers are elevated autism, indicating that oxidative increased this disease. Levels major antioxidant serum proteins, namely transferrin (iron-binding protein)...
Autism is characterized by a broad spectrum of clinical manifestations including qualitative impairments in social interactions and communication, repetitive stereotyped patterns behavior. Abnormal acceleration brain growth early childhood, signs slower neurons, minicolumn developmental abnormalities suggest multiregional alterations. The aim this study was to detect the focal defects identify regions that are prone alterations autism. Formalin-fixed hemispheres 13 autistic (4–60 years age)...
Oxidative damage is a major feature in the pathophysiology of Alzheimer's disease (AD). In this review, we discuss free radical-mediated to biochemical components involved pathology and clinical symptoms AD. We explain how amyloid beta-protein (Aβ), microtubule-associated protein tau, presenilins , apolipoprotein E mitochondria proteases play role increasing oxidative stress Aβ not only can induce but its generation also increased as result stress. Finally, hypothetical model linking with...
Mitochondria play important roles in generation of free radicals, ATP formation, and apoptosis. We studied the levels mitochondrial electron transport chain (ETC) complexes, that is, complexes I, II, III, IV, V, brain tissue samples from cerebellum frontal, parietal, occipital, temporal cortices subjects with autism age-matched control subjects. The were divided into two groups according to their ages: Group A (children, ages 4-10 years) B (adults, 14-39 years). In A, we observed...
Amyloid beta-protein (Aβ) is the major component of senile plaques and cerebrovascular amyloid deposits in individuals with Alzheimer’s disease. Aβ known to increase free radical production neuronal cells, leading oxidative stress cell death. Recently, considerable attention has been focused on dietary antioxidants that are able scavenge reactive oxygen species (ROS), thereby offering protection against stress. Walnuts rich components have anti-oxidant anti-inflammatory properties. The...
Autism is a neurodevelopmental disorder associated with social deficits and behavioral abnormalities. Recent evidence suggests that mitochondrial dysfunction oxidative stress may contribute to the etiology of autism. This first study compare activities electron transport chain (ETC) complexes (I–V) pyruvate dehydrogenase (PDH), as well DNA (mtDNA) copy number in frontal cortex tissues from autistic age-matched control subjects. The I, V PDH were most affected autism (n=14) being...
Although the pathogenesis of autism is not understood, emerging evidence points to apoptotic mechanisms being involved in this disorder. However, it known whether apoptosis signaling deregulated brain autistic subjects. This study investigates how apoptosis-related proteins are regulated brain. Our studies show that Bcl2 significantly decreased, whereas expression p53 increased, subjects comparison with age-matched controls. We also found and phosphorylation/activation Akt kinase regulates...
The purposes of this study were to identify differences in patterns developmental abnormalities between the brains individuals with autism unknown etiology and those duplications chromosome 15q11.2-q13 (dup[15]) alterations that may contribute seizures sudden death latter. Brains 9 subjects dup(15), 10 idiopathic autism, 7 controls examined. In dup(15) cohort, (78%) had seizures, 6 (67%) experienced unexplained death. Subjects microcephalic, mean brain weights 300 g less (1,177 g) than...
Previous in vitro studies have shown that walnut extract can inhibit amyloid-β (Aβ) fibrillization, solubilize its fibrils, and has a protective effect against Aβ-induced oxidative stress cellular death. In this study, we analyzed the
Actin-binding proteins such as profilin and gelsolin bind to phosphatidylinositol (PI) 4,5-bisphosphate (PI 4,5-P2) regulate the concentration of monomeric actin. We report here that stimulate PI 3-kinase-mediated phosphorylation 4,5-P2 (lipid kinase activity) in a concentration-dependent manner. This effect is specific because other cytoskeletal tau or actin do not affect 3-kinase activity. In addition lipid activity, also has protein activity: it phosphorylates (p85 subunit 3-kinase)....