A5029707714- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Neurogenetic and Muscular Disorders Research
- Computational Drug Discovery Methods
- Gene Regulatory Network Analysis
- Bioinformatics and Genomic Networks
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- NF-κB Signaling Pathways
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Microbial Natural Products and Biosynthesis
- Protein Kinase Regulation and GTPase Signaling
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle Physiology and Disorders
- Neurological Disease Mechanisms and Treatments
- Frailty in Older Adults
Harvard University
2020-2021
Arizona State University
2004
University of North Carolina at Chapel Hill
1994-1996
Abstract Chronic traumatic encephalopathy (CTE) is a progressive tauopathy found in contact sport athletes, military veterans, and others exposed to repetitive head impacts. White matter rarefaction axonal loss have been reported CTE but not characterized on molecular or cellular level. Here, we present RNA sequencing profiles of cell nuclei from postmortem dorsolateral frontal white eight individuals with neuropathologically confirmed age- sex-matched controls. Analyzing these using...
In this paper we propose to use recent developments in knowledge representation languages and reasoning methodologies for representing about signaling networks. Our approach is different from most other qualitative systems biology approaches that it based on (or inferencing) rather than simulation. Some of the advantages our are, can advances with incomplete partial information deal gaps signal network knowledge; perform various kinds such as planning, hypothetical explaining...
Postmortem magnetic resonance (MR) imaging features of different types lobar cerebral infarction are correlated with the findings in gross and histologic specimens. The postmortem also vivo similar cases selected from teaching files. In acute infarction, white matter vasogenic edema leads to high signal intensity on T2-weighted images blurring gray-white junction. Petechial hemorrhage cortex results inhomogeneous images. laminar necrosis, hyperintense T1-weighted is due not but possibly...
We have generated a line of transgenic mice that when homozygous for the transgene develop severe, adult-onset neuromuscular disorder. This mutation is likely result insertional inactivation an endogenous gene by integration. The mutant gait abnormality with stiffened and/or splayed hind legs, and adopt hunched posture some exhibiting kyphosis thoracic spine. These symptoms progress gradually to severe motor dysfunction. Pathologic changes were found in skeletal muscle peripheral nerve...
Abstract Chronic traumatic encephalopathy (CTE) is a progressive tauopathy found in contact sport athletes, military veterans, and others exposed to repetitive head impacts (RHI)1–6. White matter atrophy axonal loss have been reported CTE but not characterized on molecular or cellular level2,7,8. Here, we present RNA sequencing profiles of cell nuclei from postmortem dorsolateral frontal white eight individuals with neuropathologically confirmed age- sex-matched controls. Analyzing these...
SUMMARY Chronic traumatic encephalopathy (CTE) is a progressive tauopathy found in contact sport athletes, military veterans, and others exposed to repetitive head impacts (RHI) 1–6 . White matter atrophy axonal loss have been reported CTE but not characterized on molecular or cellular level 2,7,8 Here, we present RNA sequencing profiles of cell nuclei from postmortem dorsolateral frontal white eight individuals with neuropathologically confirmed age- sex-matched controls. Analyzing these...
We propose a formal language to represent and reason about signal transduction networks. The existing approaches such as ones based on Petri nets, /spl pi/-calculus fall short in many ways our work suggests that an artificial intelligence (AI) approach may be well suited for aspects. apply form of action NF/spl kappa/B dependent signaling pathways. Our supports several essential features reasoning with knowledge, as: partial (or incomplete) triggered evolutions the world elaboration...