A5068566231- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Animal Virus Infections Studies
- Plant Virus Research Studies
- interferon and immune responses
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
Ministry of Health of the Russian Federation
2024
D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences
2004
Introduction. Many different vaccines for the prevention of COVID-19 have received emergency use approval in shortest possible time. Due to high rate variability pathogen, this study we analyzed structural proteins SARS-CoV-2 virus and compared their protective potential protecting animals from COVID-19. The aim was compare Materials methods. used study. Transgenic mice B6.Cg-Tg(K18-ACE2)2Prlmn/J (F1) were as model animals. Recombinant adenoviral vectors rAd5-S, rAd5-N, rAd5-M immunization...
The SARS-CoV-2 virus continuously acquires mutations, leading to the emergence of new variants. Notably, effectiveness global vaccination efforts has significantly declined with rise and spread B.1.1.529 (Omicron) variant.
Background: The effectiveness of barrier function the respiratory mucosa largely depends on interferons type I (IFNs-α/β) and III (IFNs-λ) IFNs-λ forms first level innate immune protection single-nucleotide polymorphisms (SNPs) affecting IFN- λ3 production were found previously study aimed to investigate a putative association SNPs rs8099917 T/G located upstream IFNL3 gene rs12979860 C/T within IFNL4 with risk pneumonia developing after infection viruses Methods: nasopharyngeal swabs,...