A5037468517- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Toxoplasma gondii Research Studies
- Dietary Effects on Health
- Cytomegalovirus and herpesvirus research
- Hydrogen's biological and therapeutic effects
- Herpesvirus Infections and Treatments
- Gout, Hyperuricemia, Uric Acid
- Parasitic Infections and Diagnostics
- Inflammasome and immune disorders
- Genital Health and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Fibroblast Growth Factor Research
- Streptococcal Infections and Treatments
- Renal Diseases and Glomerulopathies
- Liver physiology and pathology
- Wnt/β-catenin signaling in development and cancer
- Urinary Bladder and Prostate Research
Qingdao University
2018-2024
Affiliated Hospital of Qingdao University
2018-2024
Shandong First Medical University
2022
Affiliated Hospital of Taishan Medical University
2022
<p>Glutamine blockade induces the up-regulation of PD-L1 in bladder cancer cells through ROS-mediated EGFR/ERK/C-Jun signaling pathway.</p>
<p>Effect of glutamine blockade at different times on bladder cancer growth.</p>
<p>Effects of Gefitinib and glutamine blockade on bladder cancer growth in BALB/C nude mice.</p>
<p>Glutamine blockade combined with anti-PD-L1 antibody to synergistically reduce bladder cancer growth.</p>
<p>Gefitinib synergizes with glutamine blockade to reduce orthotopic bladder cancer growth in C57BL/6 mice.</p>
<p>Gefitinib synergizes with glutamine blockade to reduce bladder cancer growth in C57BL/6 mice.</p>
<p>Glutamine metabolism participates in the malignant progression of bladder cancer patients.</p>
<div>Abstract<p>Glutamine is a major energy source for tumor cells, and blocking glutamine metabolism being investigated as promising strategy cancer therapy. However, the antitumor effect of blockade in bladder remains unclear, necessitating further investigation. In this study, we demonstrated that was involved malignant progression cancer. Treatment with antagonist 6-diazo-5-oxo-L-norleucine (DON) inhibited growth cells <i>in vitro</i> several ways. addition,...
<p>Glutamine blockade up-regulates the expression of PD-L1 in bladder cancer cells by activating EGFR/ERK/C-Jun pathway.</p>
<p>Glutamine blockade suppresses cell proliferation, cycle progression and aerobic glycolysis promotes apoptosis of bladder cancer cells.</p>
<p>Glutamine blockade affects multiple biological processes and causes up-regulation of PD-L1 in bladder cancer cells.</p>
The association between Toxoplasma gondii (T. gondii) infection and diabetes mellitus remains controversial. With the improvement of living standards, prevalence rate is steadily increasing in China. Thus, it necessary to explore possible toxoplasmosis Hence, case-control studies were conducted T. seroprevalence identify risk factors transmission routes different types diabetes, including type 1 (T1DM), 2 (T2DM), gestational (GDM) patients Four hundred serum samples for each mellitus,...
Abstract Background and Objectives Periodontitis is a chronic inflammatory disease linked to pyroptosis, an cell death process. Macrophages are essential for maintaining microenvironment homeostasis, which crucial periodontal health. This study explores the mechanisms underlying relationship between macrophage pyroptosis periodontitis. Methods Expression of marker gasdermin E (GSDME) surface CD68 was examined by immunofluorescence double staining in healthy periodontitis gingival tissues. In...
The aim of this study was to explore the epidemiology Toxoplasma gondii infection in patients with colorectal cancer (CRC) eastern China. Therefore, 287 primary CRC and age-matched healthy control subjects were recruited estimate seroprevalence T. identify risk factors infection. Enzyme-linked immunoassays used test for anti-T. immunoglobulin G (IgG) IgM antibodies. Forty-six (16%) samples positive IgG antibodies CRC, compared 26 (9.1%) controls, a significant difference ( <math...
Objective . Molecular hydrogen (H 2 ) has been considered a potential therapeutic target in many cancers. Therefore, we sought to assess the effect of H on colorectal cancer (CRC) this study. Methods The proliferation and apoptosis RKO, SW480, HCT116 CRC cell lines was assayed by CCK‐8, colony formation, flow cytometry assays. tumor growth observed xenograft implantation models (inhalation 67% two hours per day). Western blot immunohistochemistry analyses were performed examine expression...
Interstitial cystitis is a diagnosis of exclusion due to the complexity its etiology and pathology, which chronic disease with an unknown etiology. To our knowledge, few studies were performed identify predictive biomarkers for interstitial cystitis.
Liver fibrosis is a severe global health problem. However, no effective antifibrotic drugs have been approved. Surf4 primarily located in the endoplasmic reticulum (ER) and mediates transport of secreted proteins from ER to Golgi apparatus. Knockout hepatic ( LKO ) mice impairs very-low-density lipoprotein secretion without causing overt liver damage. Here, we found that collagen levels are significantly reduced compared with control flox mice, as demonstrated by proteomics, Western blot,...
Abstract Glutamine is a major energy source for tumor cells and blocking glutamine metabolism being investigated as promising strategy cancer therapy. However, the antitumor effect of blockade in bladder remains unclear, necessitating further investigation. Here, we demonstrated that was involved malignant progression cancer. Treatment with antagonist 6-Diazo-5-oxo-L-norleucine (DON) inhibited growth vitro several ways. In addition, observed inhibition cancer-bearing mice using JHU083,...