A5015810296- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Biosimilars and Bioanalytical Methods
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Ovarian function and disorders
- Influenza Virus Research Studies
- Pharmaceutical Economics and Policy
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Ocular Infections and Treatments
- Childhood Cancer Survivors' Quality of Life
- Electronic Health Records Systems
- Global Health Care Issues
- Data-Driven Disease Surveillance
- Skin Protection and Aging
- Biomedical Text Mining and Ontologies
- Multiple Sclerosis Research Studies
- Statistical Methods in Clinical Trials
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Frailty in Older Adults
- Bone health and osteoporosis research
- Helicobacter pylori-related gastroenterology studies
- Healthcare Operations and Scheduling Optimization
Université Paris Cité
2007-2019
Délégation Paris 5
2007-2019
Hôpital Européen Georges-Pompidou
2012
Assistance Publique – Hôpitaux de Paris
2012
Descartes (Belgium)
2009-2010
Laboratoire Interdisciplinaire pour la Sociologie Economique
2009
Délégation Paris 6
2007
Merck Serono (Switzerland)
2002-2005
Merck Serono (Italy)
2000-2004
McMaster University
2002-2003
This study aims to validate the Multiple Sclerosis (MS) International Quality of Life (MusiQoL) questionnaire, a multi-dimensional, self-administered available in 14 languages, as disease-specific quality life scale that can be applied internationally. A total 1992 patients with different types and severities MS from 15 countries were recruited. At baseline day 21 ± 7, each patient completed MusiQoL, symptom checklist short-form (SF)-36 QoL questionnaire. Neurologists also collected...
To assess by simulation the cost-effectiveness of intrathecal baclofen (ITB) therapy compared with conventional medical treatments for patients disabling spasticity and functional dependence caused any neurological disease.Two models were created to simulate therapeutic strategies managing severe spasticity, one without use ITB, various treatment sequences over 2 years based on current practices in France. Successful at each evaluation was defined as a combination of: (1) increased patient...
We assess the cost-effectiveness of dental implant first-line strategy vs. fixed partial denture in patients suffering from one single missing tooth.The model used a simulation decision framework over 20-year period. Potential treatment switches can occur every 5 years. Transition probabilities come literature, epidemiological reports or expert opinions. They have been programmed using specific distribution ranges to simulate patients' and practice variability, take into account parameter...
Abstract Background Data from clinical trials comparing Helicobacter pylori ( H. ) management strategies in patients with dyspepsia are limited. Cost‐effectiveness simulation models might help to identify the optimal strategy. Objective To assess cost‐effectiveness of "Test and Treat" (T&T) strategy including use urea breath test (UBT) vs symptomatic treatment (ST) upper gastrointestinal endoscopy (UGE) as a first procedure dyspepsia. Methods Three main strategies: “T&T” UBT, "UGE"...
The aim of this study was to investigate potential statistical relationships between black tea consumption and key health indicators in the world. research question is: Does is correlated with one or more epidemiological indicators?Ecological using a systematic data-mining approach which unit analysis population country.Six variables, data prevalence respiratory diseases, infectious cancer, cardiovascular diseases diabetes, have been studied at global level.Data from 50 participating...
BACKGROUND: The purpose of this study was to undertake an economic evaluation compare the cost-effectiveness recombinant (r)FSH with urinary (u)FSH for attaining clinical pregnancy assisted reproduction. METHODS: Mathematical modelling utilized incorporating a Markovian decision framework and Monte Carlo simulation. Statistical representations recurrent events over time were incorporated into analysis involving fresh frozen cycles in any sequence (after first embryo transfer cycle) three...
<h2>Abstract</h2> Objective: To compare the cost effectiveness of recombinant human FSH (Gonal-F; Serono, Inc., Randolph, MA) and urinary (Fertinex; Inc.) for ovarian stimulation during IVF with or without intracytoplasmic sperm injection treatment infertility. Design: Clinical decision analysis techniques (the Markov model) were used to model direct medical costs per patient assisted reproductive technology. Main Outcome Measure(s): economic outcomes two different protocols (recombinant...
Background . The objective of this simulation model was to assess the cost-effectiveness different biological treatment strategies based on levels disease activity in Spain, patients with moderate severe active RA and an insufficient response at least one anti-TNF agent. Methods Clinically meaningful effectiveness criteria were defined using DAS28 scores: remission Low Disease Activity State (LDAS) thresholds. Monte-Carlo simulations conducted over 2 years four sequential composed agents...
Background: Purulent bacterial conjunctivitis affects all ages with high frequency in newborns and children. In a subset of 150 children included large study having enrolled 1043 patients, our aim was to analyze children, the efficacy safety azithromycin 1.5% eye-drops treatment this disease. Methods: This multicenter, randomized, investigator-masked, parallel-group study, adolescents compare eye drops twice daily for 3 days tobramycin 0.3% 1 drop every 2 hours then 4 times 5 days. Out...
Yellow fever (YF) virtually disappeared in francophone West African countries as a result of YF mass vaccination campaigns carried out between 1940 and 1953. However, because the failure to continue campaigns, resurgence deadly disease many began early 1980s. We developed an original modeling approach assess epidemic risk (vulnerability) prioritize populations be vaccinated.We chose two-step assessment vulnerability at district level consisting quantitative qualitative per country....
Objective. The objective of this cost-of-illness study was to assess the use direct medical resources, excluding drug costs, by patients with rheumatoid arthritis (RA) in France, and construct cost estimates according level disease activity. Methods. Three categories RA activity were defined Disease Activity Score 28-joint count (DAS28) thresholds: remission (DAS28 < 2.6), low state (LDAS; i.e., DAS28 ≤ 3.2), moderate high (MHDAS; > 3.2). Eight resource utilization items defined:...
To develop a new quality-of-life (QoL) instrument with international validity that specifically assesses cosmetic products and physical appearance.In the first phase, semidirected interviews involved 309 subjects. In second stage, an acceptability study was performed on 874 Thereafter, we recruited total of 3231 subjects, each whom completed BeautyQoL questionnaire, clinical checklist for skin, generic QoL 36-Item Short Form Health Survey, sociodemographic questionnaire. A retest 8 days...
Background Influenza-like illness (ILI) is a common reason for paediatric consultations. Viral causes predominate, but antibiotics are used frequently. With regard to influenza, pneumococcal coinfections considered major contributors morbidity/mortality. Methods In the context of perennial quality management (QM) programme at Charité Departments Paediatrics and Microbiology in collaboration with Robert Koch Institute, children aged 0–18 years presenting signs symptoms ILI were followed from...
Accumulating evidence suggests that oral supplementation with myo-Inositol (myo-Ins) is able to reduce the amount of gonadotropins and days controlled ovarian hyperstimulation (COS) necessary achieve adequate oocyte maturation in assisted reproduction technology (ART) protocols, particularly women affected by polycystic ovary syndrome (PCOS). We used computational calculations based on simulation modellings. simulated vitro fertilization (IVF) procedures-with or without intracytoplasmic...