A5030150540- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Lymphoma Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
- Total Knee Arthroplasty Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Knee injuries and reconstruction techniques
- Inflammatory mediators and NSAID effects
- Inflammatory Bowel Disease
- Viral Infections and Immunology Research
- Pharmaceutical studies and practices
- Bone and Joint Diseases
- Peripheral Neuropathies and Disorders
- Autoimmune Bullous Skin Diseases
- Lower Extremity Biomechanics and Pathologies
- Cytokine Signaling Pathways and Interactions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal synovial abnormalities and treatments
Université de Montréal
2013-2024
Montreal Clinical Research Institute
2014-2024
Centre Hospitalier de l’Université de Montréal
2014-2023
Johns Hopkins University
2022
Johns Hopkins Medicine
2022
University of Toronto
1994-2020
Memorial University of Newfoundland
2015-2020
Keystone College
2020
University of Saskatchewan
2020
McMaster University
2020
<b>Background:</b> The relation between knee meniscal structural damage and cartilage degradation is plausible but not yet clearly proven. <b>Objectives:</b> To quantitate the volume changes in osteoarthritis using magnetic resonance imaging (MRI), determine whether alteration predicts loss over time. <b>Methods:</b> 32 patients meeting ACR criteria for symptomatic were studied. MRI acquisitions done every six months two years. volumes of different regions measured. Three indices change...
Abstract Objective To evaluate the safety and efficacy of long‐term intraarticular (IA) steroid injections for knee pain related to osteoarthritis (OA). Methods In a randomized, double‐blind trial, 68 patients with OA received IA triamcinolone acetonide 40 mg (34 patients) or saline into study every 3 months up 2 years. The primary outcome variable was radiologic progression joint space narrowing injected after Measurements minimum width were performed by an automated computerized method on...
Objective. The Canadian Rheumatology Association (CRA) has developed recommendations for the pharmacological management of rheumatoid arthritis (RA) with traditional and biologic disease-modifying antirheumatic drugs (DMARD) in 2 parts. Part 1 is reported here. Methods. CRA Therapeutics Committee assembled a national working group RA clinical experts, researchers, patient consumers, general practitioner. Treatment questions were priori based on results needs assessment survey. A systematic...
Upadacitinib is an oral selective Janus kinase inhibitor to treat rheumatoid arthritis. The efficacy and safety of upadacitinib as compared with abatacept, a T-cell costimulation modulator, in patients arthritis refractory biologic disease-modifying antirheumatic drugs (DMARDs) are unclear.
Abstract Objective . To compare the relative efficacy and tolerability of amitriptyline, cyclobenzaprine, placebo in treatment fibromyalgia, to identify predictors response amitriptyline cyclobenzaprine. Methods , Two hundred eight patients who fulfilled American College Rheumatology criteria for classification fibromyalgia were entered into a 6‐month prospective, double‐blind, multicenter trial randomized 1 3 groups: or placebo. Results After month, 21%, 12%, 0% patients, respectively, had...
Abstract Objective To evaluate the change in osteoarthritic (OA) knee cartilage volume over a two‐year period with use of magnetic resonance imaging (MRI) and to correlate MRI changes radiologic changes. Methods Thirty‐two patients symptomatic OA underwent at baseline 6, 12, 18, 24 months. Loss volumes were computed contrasted clinical variables for standardized semiflexed radiographs 1 2 years. Results Progression loss all followup points was statistically significant ( P < 0.0001), mean...
Abstract The objective of this study was to further explore the cartilage volume changes in knee osteoarthritis (OA) over time using quantitative magnetic resonance imaging (qMRI). These were correlated with demographic, clinical, and radiological data better identify disease risk features. We selected 107 patients from a large trial (n = 1,232) evaluating effect bisphosphonate on OA knees. MRI acquisitions done at baseline, 12, 24 months. Cartilage global, medial, lateral compartments...
Abstract The objective of this study was to identify, on a symptomatic knee osteoarthritis (OA) cohort, the risk factors associated with progression disease. More specifically, we investigated correlation between cartilage volume loss from subregions over span 24 months by means quantitative magnetic resonance imaging (qMRI) demographic, clinical, radiological, and MRI structural changes. A cohort 107 patients OA selected large trial evaluating effect bisphosphonate underwent x-rays at...
To evaluate in patients with knee osteoarthritis (OA) the size changes bone oedema and cysts over 24 months, to contrast these cartilage volume loss using quantitative magnetic resonance imaging.107 OA, selected from a large trial evaluating effect of bisphosphonate, were analysed by imaging at baseline months. Assessments subchondral cysts, done.At baseline, 86 showed presence least one type lesion: 71 oedema, 61 51 both. At although not statistically significant, total change increased...
We examined the histologic and immunopathologic features of synovial membrane 18 patients with rheumatoid arthritis (RA) 12 osteoarthritis (OA) who had undergone total knee arthroplasty. Patients were classified into 5 groups according to therapeutic regimen disease: RA treated nonsteroidal antiinflammatory drugs (NSAIDs), NSAIDs prednisone, methotrexate (MTX), OA analgesics, NSAIDs. There no significant between-group differences in percentages or distribution pattern infiltrating T cell...
In a multicentre study to explore the effects of licofelone as disease-modifying osteoarthritis drug in comparison with naproxen patients knee (OA), using MRI and x-ray examination.Patients OA (n = 355) were randomised receive either (200 mg twice day) or (500 day). examinations performed at baseline, 6 months (MRI only), 12 24 months. was used assess quantitatively changes cartilage volume, (Lyon-Schuss) measure mean minimum joint space width (JSW) medial compartment. Questionnaires probing...
Objective. The Canadian Rheumatology Association (CRA) has developed recommendations for the pharmacological management of rheumatoid arthritis (RA) with traditional and biologic disease-modifying antirheumatic drugs (DMARD) in 2 parts. Part II, focusing on specific safety aspects treatment DMARD patients RA, is reported here. Methods. Key questions were identified a priori based results national needs-assessment survey. A systematic review all clinical practice guidelines consensus...
Background: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient population remain suboptimal. Objectives: To evaluate the safety and efficacy of vaccines in individuals exposed to provide evidence-based clinical practice recommendations. Methods: A literature search patients (2009-2017) was conducted. Results were assessed using Grading Recommendation,...
Objective To evaluate the efficacy and safety of diacerein, a drug with interleukin-1β–inhibitory activity in vitro, patients knee osteoarthritis (OA). Methods A total 484 fulfilling American College Rheumatology criteria for OA were enrolled this 16-week, randomized, double-blind, placebo-controlled, parallel study group 3 diacerein dosages 50 mg/day, 100 150 mg/day (administered twice daily). Results In intent-to-treat population, (50 mg daily) was significantly superior (P < 0.05) to...