A5004729460- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Neurogenesis and neuroplasticity mechanisms
- Apelin-related biomedical research
- Zebrafish Biomedical Research Applications
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disorders and Treatments
- Muscle activation and electromyography studies
- Vestibular and auditory disorders
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury Research
- Pain Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Hemispheric Asymmetry in Neuroscience
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- Motor Control and Adaptation
- Genetics and Physical Performance
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- Memory and Neural Mechanisms
- Cardiovascular and exercise physiology
Illinois Wesleyan University
2012-2021
Medical University of South Carolina
2013
The University of Texas at Austin
2011-2013
University of Wisconsin–Milwaukee
2009-2011
Background. Motor rehabilitative training improves behavioral functionality and promotes beneficial neural reorganization following stroke but is often insufficient to normalize function. Rodent studies have relied on skilled reaching tasks model motor rehabilitation explore factors contributing its efficacy. It has been found that greater intensity (sessions/day) duration (training days) facilitates skill learning in intact animals. Whether efficacy varies with unclear. Methods. Mice were...
Background. The incidence of stroke in adulthood increases with advancing age, but there is little understanding how poststroke treatment should be tailored by age. Objective. goal this study was to determine if age and task specificity rehabilitative training affect behavioral improvement motor cortical organization after stroke. Methods. Young aged mice were trained proficiency on the Pasta Matrix Reaching Task prior lesion induction primary cortex endothelin-1. After a short recovery...
Aerobic exercise promotes rapid and profound alterations in the brain. Depending upon pattern duration of exercise, these changes brain may extend beyond traditional motor areas to regions structures normally linked learning, cognition, emotion. Exercise-induced include blood flow, hormone growth factor release, receptor expression, angiogenesis, apoptosis, neurogenesis, synaptogenesis. Together, we believe that underlie elevations mood prompt heightened behavioral plasticity commonly...
In its strictest application, the term "reinforcement learning" refers to a computational approach learning in which an agent (often machine) interacts with mutable environment maximize reward through trial and error. The borrows essentials from several fields, most notably Computer Science, Behavioral Neuroscience, Psychology. At basic level, neural system capable of mediating reinforcement must be able acquire sensory information about external internal milieu (either directly or...
Long-term aerobic exercise improves cognition in both human and nonhuman animals induces plastic changes the central nervous system (CNS), including neurogenesis angiogenesis. However, early immediate effects of on CNS have not been adequately explored. There is some evidence to suggest that initially challenging commonly associated with chronic may result as adaptations this challenge. The current experiment assessed levels apoptosis, angiogenesis, during first week an regimen adult rat....
Mouse models have become increasingly popular in the field of behavioral neuroscience, and specifically studies experimental stroke. As advance, it is important to develop sensitive measures specific mouse. The present protocol describes a skilled motor task for use mouse Pasta Matrix Reaching Task functions as versatile assay that permits experimenters collect accurate outcome data manipulate limb mimic human clinical phenomena including compensatory strategies (i.e., learned non-use)...
Stroke is a leading cause of long-term disability, though current rehabilitative strategies fail to yield complete recovery. Focused training the impaired limb improves functional outcome in rodents, but these require intensive that difficult practice humans. Because aerobic exercise has been found induce beneficial changes brain, it promising strategy after stroke. The study investigated effect voluntary poststroke on young and aged mice. Mice were trained skilled reaching task before...
Background Stroke is a leading cause of disability worldwide. Focused training the impaired limb has been shown to improve its functional outcome in animal models. However, most human stroke survivors exhibit persistent motor deficits, likely due differences rehabilitation intensity between experimental (animal) and clinical (human) settings. Objective The current study investigated effect on behavioral mouse model stroke. Methods Mice were trained preoperatively skilled reaching task. After...