A5024206249- Estrogen and related hormone effects
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Click Chemistry and Applications
- S100 Proteins and Annexins
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
- Protein Degradation and Inhibitors
- Advanced Biosensing Techniques and Applications
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- RNA Research and Splicing
Magee-Womens Research Institute
2020-2025
UPMC Hillman Cancer Center
2020-2025
Cancer Research Center
2020-2025
University of Pittsburgh
2020-2024
University of Pittsburgh Medical Center
2020
Abstract As one of the most successful cancer therapeutic targets, estrogen receptor-α (ER/ESR1) has been extensively studied over past few decades. Sequencing technological advances have enabled genome-wide analysis ER action. However, comparison individual studies is limited by different experimental designs, and meta-analyses are available. Here, we established EstroGene database through unified processing data from 246 experiments including 136 transcriptomic, cistromic, epigenetic...
Abstract Background Resistance to endocrine therapy is a major challenge of managing estrogen receptor positive (ER+) breast cancer. We previously reported frequent overexpression FGFR4 in resistant cell lines and cancers that recurred metastasized following therapy, suggesting as potential driver resistance. In this study, we investigated the role mediating resistance explored therapeutic targeting advanced Methods A gene expression signature activity was examined ER+ cancer pre-...
<div>Abstract<p>As one of the most successful cancer therapeutic targets, estrogen receptor-α (ER/ESR1) has been extensively studied over past few decades. Sequencing technological advances have enabled genome-wide analysis ER action. However, comparison individual studies is limited by different experimental designs, and meta-analyses are available. Here, we established EstroGene database through unified processing data from 246 experiments including 136 transcriptomic,...
<p>Supplementary FigureS1-S5</p>