An efficient protocol for the generation of amines by palladium-catalyzed nucleophilic benzylic addition 2-methyl-substituted azaarenes to N-sulfonyl aldimines under neutral conditions via C−H bond activation has been developed. This reaction represents a very methodology synthesis heterocycle-containing and thus opens new way access through activation.

An efficient and conceptually new method for oxidative amination of azoles with tertiary amines via copper-catalyzed C-H C-N bond activation has been developed. This protocol can be performed in the absence external base only requires atmospheric oxygen as oxidant. The catalyst system is very simple efficient, which opens a way using nitrogen group sources formation reactions.

A new strategy for generating benzylpalladium reactive species from toluenes via nondirected C(sp3)–H activation has been developed. This led to construction of an efficient Pd-catalyzed reaction protocol the oxidative carboxylation benzylic C–H bonds form substituted 2-phenylacetic acid esters and derivatives inexpensive, commercially available starting materials.

A novel iron-catalyzed alkenylation of 2-substituted azaarenes through sp3 C–H bond activation has been developed. favorable E2-elimination is proposed as a key step to cleavage and C–N bonds for the construction C═C in high stereoselectivity. This transformation represents an efficient way synthesize 2-alkenylated from simple starting materials.

Intermolecular carboamination of olefins with general alkyl groups is an unsolved problem. Diastereoselective acyclic represents additional challenge in intermolecular carboaminations. We have developed a alkylamination vinylarenes and the unprecedented diastereoselective anti-carboamination unsaturated esters, generating amines unnatural β-amino acids. This enabled by difunctional alkylating reagents iron catalyst. Alkyl diacyl peroxides, readily synthesized from aliphatic acids, serve as...

Nitrogen revives: Cyclic N-acyliminium ions were generated from α,β-unsaturated γ-lactams (1) and underwent intermolecular addition by indole nucleophiles (2) under the catalysis of a chiral Brønsted acid (3). A variety N-functionalized derivatives containing pyrrolidinone moiety (4) assembled with high enantioselectivity. Bn=benzyl.

Abstract Because of the lack effective alkylating reagents, alkyl etherification olefins with general groups has not been previously reported. In this work, a variety diacyl peroxides and peresters generated from aliphatic acids have found to enable first iron‐catalyzed groups. Primary, secondary tertiary are suitable for reaction, delivering products yields up 97 %. Primary alcohols react well, affording in 91 % yield.

A new strategy was developed for intercepting the palladium–alkyl species generated in Heck reaction via nucleophilic addition prior to step of migratory insertion, which leads a palladium-catalyzed difunctionalization enol ethers with aminals and alcohols afford amino acetals. Mechanistic studies suggested that cationic cyclometalated Pd(II) complex by oxidative aminal Pd(0) crucial this unusual transformation.

A highly dispersed Rh catalyst supported on nitrogen-doped carbon nanotubes (CNTs) was prepared using a one-pot method and exhibited catalytic performance in the hydroformylation of olefin.

Abstract The Lewis acid‐catalyzed CH functionalization of 2‐substituted azaarenes with N ‐sulfonylaldimines has been developed, which provides a rapid and efficient approach for synthesis heterocycle‐containing isoindolinones isoindolines.

Acid test: With a Brønsted acid as the solvent, rhodium-catalyzed direct addition of aryl CH bonds to α,β-unsaturated ketones was realized under mild reaction conditions (see scheme). The may assist by interceding in conflict two proton-transfer events and averting substrate inhibition involved this type reaction. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted...

Copper catalyzed 1,2-alkylesterification of 1,3-dienes with diacyl peroxides affords branched allylic esters in excellent regioselectivity, including products a newly generated fully substituted carbon center. The only byproduct is CO2. reaction proceeds by radical mechanism as suggested spin trap and crossover experiments.

An environmentally benign, copper-catalyzed diazidation of a broad range olefins, including vinylarenes, unactivated alkenes, allene, and dienes, under mild conditions with TMSN3 (trimethylazidosilane) as azido source, has been developed. This reaction can be carried out in organic solvent or aqueous solution where water is the sole solvent. The functional group compatibility this good, which proved by late-stage functionalizations complex substrates.

A cooperative catalytic system established by the combination of an iron salt and a chiral Brønsted acid has proven to be effective in asymmetric Friedel-Crafts alkylation indoles with beta-aryl alpha'-hydroxy enones. Good excellent yields enatioselectivities were observed for variety enones indoles, particularly bearing electron-withdrawing group at para position phenyl ring (up 90 % yield 91 ee). The proton acid, Lewis activation site, as well inherent basic site hydrogen-bonding...

This paper reports a new method for the generation of substituted 1,3-enynes, whose synthesis by other methods could be challenge. The dehydrative decarboxylative cascade coupling reaction propargyl alcohol with alkyl peroxides is enabled an iron catalyst and alkylating reagents. Primary, secondary, tertiary groups can introduced into affording various 1,3-enynes in moderate to good yields. Mechanistic studies suggest involvement radical-polar crossover pathway.

This mini-review provides the recent progress towards catalysts for hydroformylation of that bridge traditional homo- and heterogeneous catalysis, highlighting future development in hydroformylation.

Abstract The N‐methylation reaction of amines with methanol via the borrowing‐hydrogen strategy is an important method for construction C−N bonds. Compared other C1 sources, such as toxic formaldehyde or expensive formic acid, more suitable reactions due to its eco‐friendliness and low price. Using this strategy, various types N‐methylated products, including biological pharmaceutical molecules have been prepared. Here, we present a thorough survey decades articles showing current...

Abstract The Lewis acid‐catalyzed conjugate addition of 2‐alkylazaarenes to methylenemalononitriles through sp 3 CH bond functionalization has been developed, which provides an efficient and reliable method for incorporation the nitrile group into heterocycles.

Abstract A conceptually new cooperative catalytic system via a synergistic combination of aldehyde and copper catalysis has been established based on systemic mechanistic studies. This successfully applied in the direct aerobic oxidative CH amination azoles at room temperature, which was previously realized under harsh conditions. Mechanistic studies including isotopic labeling experiments kinetic isotope effect (KIE) support reaction pathway that involves formation an aminal, hydrolysis...

An iron(II)-catalyzed radical alkyl Heck-type reaction of iodides with vinylarenes under mild conditions has been reported. t-Butyl peroxybenzoate (TBPB) behaves simultaneously as a relay initiator, precursor for the generation from iodides, and an oxidant to recycle iron(II)/iron(III). Unactivated primary, secondary, tertiary are compatible conditions. The mechanistic studies suggest that radical-polar-crossover pathway might be involved in catalytic cycle.

Abstract Carbon dioxide based degradable polycarbonate can be obtained through the copolymerization reaction of carbon with epoxide in presence a catalyst. This polymer has attracted much attention recent years owing to its environmentally friendly and sustainable characteristics, excellent material properties. Due unique properties, CO2-based wide range applications many fields such as electronic electrical parts, automotive medical devices, aerospace equipment, power radiation protection...

A novel iodine-catalyzed tandem cyclization–cycloaddition reaction of ortho-alkynyl-substituted benzaldehydes leading to polyoxacyclic ring systems has been developed, which represents a useful approach towards the synthesis oxabicyclo-[3.2.1]octane skeleton found in variety natural products.

Abstract Because of the lack effective alkylating reagents, alkyl etherification olefins with general groups has not been previously reported. In this work, a variety diacyl peroxides and peresters generated from aliphatic acids have found to enable first iron‐catalyzed groups. Primary, secondary tertiary are suitable for reaction, delivering products yields up 97 %. Primary alcohols react well, affording in 91 % yield.